Recent Advances in the Synthesis of Fused‐Cyclic Quinolines

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(5)

Published: Feb. 16, 2024

Abstract Fused quinolines have gained substantial attention due to their significant biological and wide‐spectrum synthetic applications. This review supplies an encyclopedic document regarding the approaches developed for synthesis of fused‐cyclic based on ring volume size reported thus far. collected information will be valuable medicinal chemists obtain knowledge designing new in order access active compounds.

Language: Английский

---

Visible-Light-Promoted Selenylation/Cyclization of o-Alkynyl Benzylazides/o-Propargyl Arylazides: Synthesis of Seleno-Substituted Isoquinolines and Quinolines

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 4176 - 4184

Published: March 4, 2024

A simple and efficient visible-light-promoted selenylation/cyclization of o-alkynyl benzylazides/o-propargyl arylazides have been realized for the practical synthesis seleno-substituted isoquinolines quinolines. This strategy provides valuable isoquinoline quinoline derivatives via construction one C(sp2)–Se bond C–N within process.

Language: Английский

---

Asymmetric ring-opening reactions of donor–acceptor cyclopropanes with 1,3-cyclodiones

RSC Advances, Journal Year: 2023, Volume and Issue: 13(11), P. 7432 - 7435

Published: Jan. 1, 2023

A series of enantioenriched γ-hydroxybutyric acid derivatives were obtained via asymmetric ring-opening reactions D–A cyclopropanes with 1,3-cyclodiones.

Language: Английский

---

I2-Catalyzed Three-Component Synthesis of 3-Selenylated Pyrazolo[1,5-a]pyrimidines

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(21), P. 9480 - 9485

Published: Jan. 1, 2024

A one-pot strategy has been developed for the synthesis of 3-selenylated pyrazolo[1,5- a ]pyrimidines from amino pyrazoles, chalcones/enaminones, and diselenides through I 2 -catalyzed tandem cascade annulations/C–H selenylation.

Language: Английский

---

Regioselective Radical Cascade Cyclizations of Alkyne-Tethered Cyclohexadienones with Chalcogenides under Visible-Light Catalysis

ACS Omega, Journal Year: 2023, Volume and Issue: 8(39), P. 35809 - 35821

Published: Sept. 20, 2023

Herein, we demonstrated a silver/K2S2O8-mediated highly regio- and diastereoselective 6/5-exo trig radical cascade cyclization of alkyne-tethered cyclohexadienones with sulfonyl hydrazides or sodium sulfinates subsequent selenation to access 6,6-dihydrochromenone 6,5-fused tetrahydro benzofuranone derivatives. This reaction protocol features high functional group compatibility has wide substrate scope providing variety dihydrochromenones derivatives in good excellent yields. The proceeds via the attack alkyne over activated Michael acceptor. TEMPO quenching experiment implies presence intermediate. Further synthetic versatility 6,6- 5,6-fused is also showcased.

Language: Английский

---

Metal-Free Synthesis of Selanyl-Substituted Chromenones via Selanylation­/Cyclization of Alkynyl Aryl Ketones

Synthesis, Journal Year: 2024, Volume and Issue: 56(16), P. 2529 - 2536

Published: June 12, 2024

Abstract A variety of 2-substituted 3-selanyl-chromenones are readily prepared through a cascade selanylation/cyclization alkynyl aryl ketones with sulfonoselenoates. This transformation is performed under metal-free conditions and does not require an additional oxidant. It also has the advantage broad functional group tolerance scalability.

Language: Английский

---

Visible-light-promoted selenylation/cyclization of o-(1-alkynyl) benzoates to access seleno-substituted isocoumarins

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(36), P. 7327 - 7331

Published: Jan. 1, 2024

A simple and efficient method to access 4-selenyl-isocoumarin derivatives through visible-light-promoted selenylation/cyclization of o -(1-alkynyl) benzoates has been developed.

Language: Английский

---