Abstract
The
C(
sp
3
)−H
functionalization
via
intramolecular
hydride
transfer
initiated
cascade
annulation
for
the
synthesis
of
spiro‐fused
succinimide‐containing
tetrahydroquinolines
induced
by
iminium
intermediates
is
described.
A
series
diastereoselective
2,7‐diazaspiro[4.5]decanes‐1,3‐diones
were
achieved
using
ortho
‐amino‐benzylidene‐succinimide
Lewis
acid
catalysis.
This
scandium
triflate
Sc(OTf)
catalysed,
oxidant‐free
protocol
leads
to
a
class
derivatives
with
48–98%
yield
in
single
step.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(12), P. 2324 - 2338
Published: Jan. 1, 2024
This
review
summarizes
the
most
recent
progress
made
in
C–H
bond
activation-initiated
spiroannulation
reactions
and
their
applications
construction
of
structurally
diverse
biologically
valuable
spirocyclic
scaffolds.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3874 - 3880
Published: Jan. 1, 2024
Presented
herein
is
a
concise
synthesis
of
diverse
pyrazolo[1,2-
]pyrazolones
based
on
condition-controlled
divergent
reactions
1-arylpyrazolidinones
with
allenyl
acetates.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(22), P. 3915 - 3926
Published: Sept. 12, 2023
Abstract
A
rhodium‐catalyzed
[5+1]
cycloaddition
via
C−H
activation/
O
‐annulation
strategy
for
synthesizing
biologically
interesting
isochromenes
is
presented.
This
protocol
selectively
provides
divergently
functionalized
containing
spirosuccinimide
and
maleimide
scaffolds
according
to
the
maleimides
itaconimides
used
as
substrates.
methodology
exhibits
an
extensive
substrate
scope,
remarkable
functional
group
tolerance,
high
regioselectivity.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(8), P. 1840 - 1846
Published: Feb. 8, 2024
Abstract
Herein,
we
report
a
chemo‐
and
regioselective
Rh‐catalyzed
redox
C7‐spiroannulation
reaction
of
N
‐benzo[
d
]imidazole
indolines
with
maleimides,
resulting
in
series
indoline
fused
azaspirocycles
up
to
92%
yield.
The
synthetic
utility
is
demonstrated
by
the
synthesis
highly
functionalized
nitrogen‐containing
spiropolycyclic
skeletons.
annulation
could
also
be
performed
maleic
esters
acrylates.
products
were
purified
simple
filtration.
Rh
catalyst
can
recycled,
at
gram‐scale
using
0.5
mol%
catalyst,
which
makes
this
protocol
potentially
applicable
industry.
Moreover,
efficient
post‐modification
pharmaceutical
molecules
demonstrates
its
practicability.
Abstract
We
report
herein
a
palladium‐catalyzed,
site‐selective
cyclative
annulation
of
o
‐alkynyl
arylamides
with
maleimide
for
the
stereoselective
construction
succinimide‐fused
benzoxazine
derivatives.
This
operationally
simple
and
modular
protocol
provides
access
to
polycyclic
frameworks.
The
other
associated
features
are
high
functional
group
compatibility,
gram‐scale
synthetic
potential,
downstream
transformations.
Control
labeling
experiments
were
conducted
get
insights
into
mechanism.
