Unveiling the role of Lewis bases in cascade furan Diels–Alder cycloadditions: asymmetric synthesis of polycyclic quinazolinones DOI
Yuhan Li, Dongyi Zhang, Zhonglin Wei

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5488 - 5494

Published: Jan. 1, 2024

A Lewis base catalyzed asymmetric substitution/IMDAF reaction for the synthesis of polycyclic quinazolinones has been developed. The key role in IMDAF process unveiled.

Language: Английский

(NH4)2S2O8 promoted tandem radical cyclization of quinazolin-4(3H)-ones with oxamic acids for the construction of fused quinazolinones under metal-free conditions DOI
Shenyuan Gao, Menglu Cai, Gang Xu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(11), P. 2241 - 2251

Published: Jan. 1, 2024

A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed.

Language: Английский

Citations

5
Photoinduced palladium-catalyzed radical addition/cyclization of unactivated alkenes with alkyl halides toward alkylated ring-fused quinazolinones DOI

Lixin Liu,

J.‐T. HUANG,

Yuanhua Li

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1008, P. 123066 - 123066

Published: Feb. 18, 2024

Language: Английский

Citations

3
Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-substituted quinazolinone derivatives DOI

Jian-Li Wu,

Meng Yan,

Lulu Fan

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 162, P. 134085 - 134085

Published: June 11, 2024

Language: Английский

Citations

2
Photoredox/HAT-Catalyzed Intramolecular Hydrocyclization of Alkenes toward 2,3-Fused Quinazolinones and Dihydroquinazolinones DOI
Dong Li, Xiaoqing Wang,

Yanhui Gou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

New photochemical approaches to 2,3-fused quinazolinones and dihydroquinazolinones are disclosed. The intramolecular hydrocyclization proceeds in moderate excellent yields across diverse alkenes with high regioselectivity diastereocontrol. Mechanistic studies indicated that the radical cascade processes involve thiophenol acting as single-electron transfer hydrogen atom reagents. success of gram-scale synthesis proves strategy can be used for practical applications.

Language: Английский

Citations

1
Metal-free Synthesis of 1,1-Dimethyl-2,2,2-trifluoroethyl Substituted Quinazolinones via Tandem Radical Cyclization of Quinazolin-4(3H)-ones with 3,3,3-Trifluoro-2,2-dimethylpropanoic acid DOI
Shenyuan Gao, Menglu Cai,

Xiaozhong Wang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(31), P. 6376 - 6384

Published: Jan. 1, 2024

A metal-free (NH

Language: Английский

Citations

0
Visible-light-induced selective hydrolipocyclization and silylation of alkenes: access to ring-fused quinazolin-4(3H)-ones and their silicon-substituted derivatives DOI
Shoucai Wang, Ziren Chen, Fei Xue

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(21), P. 6019 - 6025

Published: Jan. 1, 2024

A visible-light-induced intermolecular silylation and hydrolipocyclization using hydrosilane as the hydrogen silicon source has been developed, which provided an efficient pathway for synthesis of organosilanes polycyclic quinazolinones.

Language: Английский

Citations

0
Unveiling the role of Lewis bases in cascade furan Diels–Alder cycloadditions: asymmetric synthesis of polycyclic quinazolinones DOI
Yuhan Li, Dongyi Zhang, Zhonglin Wei

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5488 - 5494

Published: Jan. 1, 2024

A Lewis base catalyzed asymmetric substitution/IMDAF reaction for the synthesis of polycyclic quinazolinones has been developed. The key role in IMDAF process unveiled.

Language: Английский

Citations

0