(NH4)2S2O8 promoted tandem radical cyclization of quinazolin-4(3H)-ones with oxamic acids for the construction of fused quinazolinones under metal-free conditions
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(11), P. 2241 - 2251
Published: Jan. 1, 2024
A
novel
cascade
radical
addition/cyclization
reaction
of
non-activated
olefins
and
oxamic
acids
has
been
proposed.
Language: Английский
Photoinduced palladium-catalyzed radical addition/cyclization of unactivated alkenes with alkyl halides toward alkylated ring-fused quinazolinones
Lixin Liu,
No information about this author
J.‐T. HUANG,
No information about this author
Yuanhua Li
No information about this author
et al.
Journal of Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
1008, P. 123066 - 123066
Published: Feb. 18, 2024
Language: Английский
Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-substituted quinazolinone derivatives
Jian-Li Wu,
No information about this author
Meng Yan,
No information about this author
Lulu Fan
No information about this author
et al.
Tetrahedron,
Journal Year:
2024,
Volume and Issue:
162, P. 134085 - 134085
Published: June 11, 2024
Language: Английский
Photoredox/HAT-Catalyzed Intramolecular Hydrocyclization of Alkenes toward 2,3-Fused Quinazolinones and Dihydroquinazolinones
Dong Li,
No information about this author
Xiaoqing Wang,
No information about this author
Yanhui Gou
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
New
photochemical
approaches
to
2,3-fused
quinazolinones
and
dihydroquinazolinones
are
disclosed.
The
intramolecular
hydrocyclization
proceeds
in
moderate
excellent
yields
across
diverse
alkenes
with
high
regioselectivity
diastereocontrol.
Mechanistic
studies
indicated
that
the
radical
cascade
processes
involve
thiophenol
acting
as
single-electron
transfer
hydrogen
atom
reagents.
success
of
gram-scale
synthesis
proves
strategy
can
be
used
for
practical
applications.
Language: Английский
Metal-free Synthesis of 1,1-Dimethyl-2,2,2-trifluoroethyl Substituted Quinazolinones via Tandem Radical Cyclization of Quinazolin-4(3H)-ones with 3,3,3-Trifluoro-2,2-dimethylpropanoic acid
Shenyuan Gao,
No information about this author
Menglu Cai,
No information about this author
Xiaozhong Wang
No information about this author
et al.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(31), P. 6376 - 6384
Published: Jan. 1, 2024
A
metal-free
(NH
Language: Английский
Visible-light-induced selective hydrolipocyclization and silylation of alkenes: access to ring-fused quinazolin-4(3H)-ones and their silicon-substituted derivatives
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(21), P. 6019 - 6025
Published: Jan. 1, 2024
A
visible-light-induced
intermolecular
silylation
and
hydrolipocyclization
using
hydrosilane
as
the
hydrogen
silicon
source
has
been
developed,
which
provided
an
efficient
pathway
for
synthesis
of
organosilanes
polycyclic
quinazolinones.
Language: Английский
Unveiling the role of Lewis bases in cascade furan Diels–Alder cycloadditions: asymmetric synthesis of polycyclic quinazolinones
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(19), P. 5488 - 5494
Published: Jan. 1, 2024
A
Lewis
base
catalyzed
asymmetric
substitution/IMDAF
reaction
for
the
synthesis
of
polycyclic
quinazolinones
has
been
developed.
The
key
role
in
IMDAF
process
unveiled.
Language: Английский