Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(12), P. 4019 - 4019
Published: Jan. 1, 2023
Spirocyclohexadienones
are
not
only
widely
present
in
bioactive
molecules,
but
also
act
as
key
synthetic
intermediates
for
the
synthesis
of
natural
products.Owing
to
great
importance
these
compounds,
their
efficient
has
drawn
considerable
attention
from
chemists.In
particular,
there
many
reports
about
spirocyclohexadienone
derivatives
via
alkyne-involving
dearomatization
past
few
years.The
success
reactions
benefits
reaction
mode:
activation
alkyne
π
bond
by
radicals,
electrophiles,
or
metal
catalysts
under
conditions
photocatalysis,
electrocatalysis,
chemical
oxidation,
and
then
subsequent
process.The
advances
electron-deficient,
electron-ordinary,
electron-rich
alkynes-participated
phenolic
realize
construction
recent
five
years
systematically
summarized.During
discussion,
used
triggering
ways
subdivided.At
last,
prospects
this
field
discussed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(5), P. 1011 - 1016
Published: Jan. 30, 2024
A
novel
strategy
was
developed
to
generate
silyl
radicals
from
silylboronic
pinacol
esters
(SPEs)
through
nucleohomolytic
substitution
of
boron
with
aminyl
radicals.
We
successfully
applied
this
obtain
diverse
organosilicon
compounds
using
SPEs
and
N-nitrosamines
under
photoirradiation
without
any
catalyst.
The
ability
access
offers
a
new
perspective
for
chemists
rapidly
construct
Si–X
bonds.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(15), P. 3069 - 3074
Published: April 1, 2024
Free
radical
three-component
nitration/spirocyclization
of
unsaturated
sulfonamides/amides
with
tert-butyl
nitrite
was
developed
for
the
construction
diverse
NO2-revised
4-azaspiro[4.5]decanes.
This
tandem
system
featured
metal-free
participation,
simple
operation,
good
selectivity/yields,
and
a
green/low-cost
O
source.
Meanwhile,
one
nitro-containing
complex
molecule
scaled-up
operation
were
performed
well
to
test
synthetic
potential
cascade
reaction.
Isotopic
labeling,
inhibition
experiments,
DFT
analysis
carried
out
gain
insight
into
reaction
process.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(25), P. 5254 - 5264
Published: Jan. 1, 2023
An
efficient
metal-
and
additive-free
nitro
radical-triggered
addition/cyclization
for
the
synthesis
of
nitro-substituted
indolo[2,1-
α
]isoquinoline
benzimidazo[2,1-
a
]isoquinolin-6(5
H
)-one
derivatives
has
been
developed.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(6)
Published: Feb. 1, 2025
Abstract
An
efficient
metal/peroxide‐free
[5
+
1]
cyclization
of
2‐vinylanilines
with
TBN
was
realized
to
access
various
cinnolines
high
yields.
In
addition,
benzo[
e
]pyrrolo[2,1‐c][1,2,4]triazines
could
also
be
obtained
by
using
2‐(1
H
‐pyrrol‐1‐yl)anilines
as
the
raw
materials.
This
cascade
system
selected
common/low‐cost
tert
‐butyl
nitrite
N1
source,
which
performed
broad
substrate
scopes/simple
operation/mild
conditions/available
scaled
up
1
mmol.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(15), P. 10925 - 10945
Published: July 17, 2023
Bromine
induced
spiro
cyclization
of
biaryl
ynones
facilitated
the
synthesis
spiro[5,5]trienones
suitable
for
extended
functionality
at
C(3')
position.
Herein,
a
step-economic
photo-oxidative
brominative
carbannulation
employing
ammonium
bromide
and
riboflavin
tetraacetate
(RFTA)
has
been
developed.
The
reactivity
between
distal
phenyl
C-H
activated
ortho-annulation
dearomative
ipso-annulation
is
well
exemplified.
eminent
features
methodology
include
metal-free,
external
additive
free,
low-loading
photocatalyst
(0.1
mol
%),
use
simple
precursor.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(46), P. 9112 - 9122
Published: Jan. 1, 2023
Organic
thiocyanates
are
valuable
biological
moities
and
drug-building
blocks.
They
can
also
transform
effectively
into
thioethers,
thiols,
alkynyl
thiocarbamates
in
synthetic
chemistry.
With
respect
to
the
merits
of
thiocyanates,
many
chemists
our
research
team
have
developed
diverse
strategies
access
SCN-revised
heterocycles/spirocycles
via
an
effective
radical
cyclization
process.
Hence,
this
review
article
first
describes
importance/application
thiocyanates.
Subsequently,
it
summarizes
reaction
conditions,
substrate
scopes,
plausible
mechanism,
respectively,
excellent
work
stated
above.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(2), P. 458 - 458
Published: Jan. 17, 2024
The
oxidative
radical
cascade
cyclization
of
alkynes
has
emerged
as
a
versatile
strategy
for
the
efficient
construction
diverse
structural
units
and
complex
molecules
in
organic
chemistry.
This
work
reports
an
alkyl
initiated
5-exo-trig
biaryl
ynones
with
1,4-dihydropyridines
to
selectively
synthesize
indenones.
