Ruthenium(II)‐Catalyzed Selective C(sp2)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate DOI
Wenbo Ma, Tao Zheng, Linghui Gu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 366(3), P. 518 - 525

Published: Dec. 29, 2023

Abstract A ruthenium‐catalyzed C( sp 2 )−H acyloxylation of 2‐aroyl pyridine derivatives with simple sodium carboxylate utilizing transformable directing groups is described. This protocol features broad functional group tolerance and chemo‐ regio‐selectivity, providing the products in 45%‐84%yield. Furthermore, synthetic utility this was demonstrated by late‐stage functionalization pharmaceutical compounds. Notably, could be further transformed into a variety useful heterocycles under mild conditions.

Language: Английский

Ru(II)‐Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes DOI

Quanjian Luo,

Han‐Chi Wang,

Jing Zhang

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(15), P. 1686 - 1690

Published: March 15, 2024

Comprehensive Summary A new, selective Ru(II)‐catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This enables the construction a new C(sp 2 )‐C(sp) bond through C—H activation C—Br functionalization, offers an effective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone phthalazinone derivatives wide substrate scope high selectivity.

Language: Английский

Citations

3
Rh-Catalyzed C–H Alkynylation of Indole Derivatives with Silver(I)-Controlled Regiodivergence DOI

Yaokun Zhao,

Xingchi Li,

Pengfei Zhou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(35), P. 7285 - 7290

Published: Aug. 23, 2024

We have disclosed silver(I)-induced switching of regioselectivity in rhodium-catalyzed C–H alkynylation indole derivatives with the help a pivaloyl directing group by tuning metalation modes. The judicious choice AgOAc, Ag2O, and Ag2CO3 affords an array C2-alkynylated indoles, C4-alkynylated C2,C4-dialkynylated respectively. synthetic utility alkyne fragment is demonstrated derivatization into valuable indole-based compounds.

Language: Английский

Citations

1
Isoxazole group directed Rh(III)-catalyzed alkynylation using TIPS-EBX DOI
Sukanya Das,

T. K. Datta,

Md. Abbasuddin Sk

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(34), P. 6922 - 6927

Published: Jan. 1, 2024

A highly effective isoxazole directed

Language: Английский

Citations

0
Ruthenium(II)‐Catalyzed Selective C(sp2)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate DOI
Wenbo Ma, Tao Zheng, Linghui Gu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 366(3), P. 518 - 525

Published: Dec. 29, 2023

Abstract A ruthenium‐catalyzed C( sp 2 )−H acyloxylation of 2‐aroyl pyridine derivatives with simple sodium carboxylate utilizing transformable directing groups is described. This protocol features broad functional group tolerance and chemo‐ regio‐selectivity, providing the products in 45%‐84%yield. Furthermore, synthetic utility this was demonstrated by late‐stage functionalization pharmaceutical compounds. Notably, could be further transformed into a variety useful heterocycles under mild conditions.

Language: Английский

Citations

0