European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 21, 2024
Abstract
A
new
environmentally
friendly
and
efficient
strategy
for
preparing
trifluoromethylated
pyrrolidones
has
been
developed.
The
process
involves
using
visible
light
to
induce
radical
cyclization
of
1,5‐dienes
with
CF
3
SO
2
Na,
resulting
in
excellent
regioselectivity.
This
method
uses
less
expensive
easy‐to‐store
trifluoromethylation
reagents,
making
it
an
attractive
option.
Additionally,
the
can
be
easily
modified
preliminary
mechanistic
studies
have
presented.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2352 - 2362
Published: April 5, 2024
Abstract
While
the
emergence
of
electrophotochemistry
provides
opportunities,
such
a
chemistry
at
this
stage
suffers
from
limited
reaction
types
and
high
photocatalyst
loadings.
A
self‐catalyzed
electrophotosynthesis
as
well
one
with
low
loading
is
presented.
These
external‐oxidant‐free
cyclizations
are
enabling
applicable
to
range
activated
alkenes,
affording
diverse
array
thiocyanato
heterocycles
including
4‐pyrrolin‐2‐ones,
isoquinoline‐1,3‐diones,
indolo[2,1‐
]isoquinolin‐6(5
H
)‐ones,
benzoimidazo[2,1‐
)‐ones
indolin‐2‐ones,
protocols
amenable
late‐stage
diversification
complex
molecular
architectures
gram‐scale
syntheses.
Sunlight
could
serve
light
source,
be
conducted
in
an
all‐solar‐driven
mode
using
commercially
available
photovoltaic
panel
produce
electricity.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
A
Mn(III)-mediated
radical
cascade
cyclization
of
N-propargyl
enamides
with
sodium
sulfinates
was
developed.
Mechanistic
studies
indicated
that
this
process
is
mainly
composed
the
chemoselective
addition
sulfonyl
to
C≡C
bond
and
regioselective
intramolecular
6-endo-trig
cyclization.
This
protocol
provided
a
powerful
method
for
divergent
synthesis
diverse
polysubstituted
meta-sulfonylpyridines
or
1,2-dihydropyridines
just
by
varying
solvent
temperature
featuring
good
functional
group
compatibility
simple
operation.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(36)
Published: April 23, 2024
Three
hybrid
electrochemical
protocols,
which
involve
the
energy
transfer,
direct
photolysis
and
N-hydroxyphthalimide
catalyst,
respectively,
are
presented
for
selenylation/cyclization
of
fragile
substrates
3-aza-1,5-dienes
with
diorganyl
diselenides
to
afford
3-selenomethyl-4-pyrrolin-2-ones.
The
two
electrophotocatalytic
reactions
indirect
electrolysis
one
both
regioselective
external-oxidant-
transition-metal-free,
associated
a
broad
substrate
scope
high
Se-economy,
all
three
methods
amenable
gram-scale
syntheses,
late-stage
functionalizations,
sunlight-induced
experiments
all-solar-driven
syntheses.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
A
novel
regioselective
manganese(III)-mediated
radical
cascade
cyclization
of
N-propargyl
enamides
with
various
H-phosphine
oxides,
H-phosphinates
and
H-phosphonates
was
developed.
Mechanistic
studies
show
that
the
reaction
is
mainly
composed
selective
addition
phosphonyl
to
C≡C
bond
intramolecular
6-endo-trig
vinyl
radical.
Utilizing
this
protocol,
we
successfully
synthesized
a
diverse
range
3-phosphorylpyridines
in
high
efficiency
good
functional
group
compatibility
simple
operation.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
A
copper(II)-catalyzed
radical
cascade
reaction
of
N-propargyl
enamides
with
sulfonyl
hydrazides
was
developed,
which
provided
an
unprecedented
method
for
the
direct
synthesis
meta-sulfonylpyridines
in
high
efficiency
good
functional
group
compatibility
and
simple
operation.
Mechanistic
studies
indicated
that
this
tandem
process
might
be
composed
addition,
intramolecular
cyclization
oxidative
aromatization.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
A
direct
alkoxycarbonyl
radical-induced
cascade
reaction
of
3-aza-1,5-dienes
with
alkyl
chlorooxoacetates
is
reported.
With
this
approach,
an
extensive
range
ester-containing
pyrrolin-2-ones
are
synthesized
through
photocatalyzed
alkoxycarbonylation/cyclization
under
mild
conditions.
Moreover,
dehydrogenative
aromatization
can
proceed
the
same
photocatalytic
system.
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
A
practical,
metal-,
and
additive-free
strategy
for
photo-
electro-induced
perfluoroalkylation/cyclization
of
o-hydroxyaryl
enaminones
with
sodium
perfluoroalkanesulfinates
under
mild
conditions
has
been
developed.
Various
fluoroalkyl
chromones
were
efficiently
assembled
in
moderate
to
good
yields.
The
scalability
this
protocol
the
assembling
diverse
nitrogen-containing
heterocycles
from
late-stage
transformations
greatly
broaden
practical
applications
developed
protocol.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(28), P. 5724 - 5728
Published: Jan. 1, 2024
Herein,
a
novel
electroreductive
carboxylation
of
benzylphosphine
salts
with
CO
2
through
cleavage
the
C(sp
3
)-P
bond
was
reported
under
conditions
without
redox
reagents
and
noble
metal
catalysts.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(20), P. 5784 - 5790
Published: Jan. 1, 2024
The
radical
cascade
cyclization
of
vinyl-tethered
alkenes
has
become
a
promising
tool
for
rapidly
assembling
nonbenzene-fused
cyclic
skeletons
via
the
cracking
alkenyl
C–H
bonds,
but
this
approach
been
limited
to
generate
five-membered
rings.
