EDA Complex-Enabled Annulation to Access CF₂-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10614 - 10623

Published: July 25, 2024

A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis fluorine-containing tetralones quinazolinones. In this transformation, persulfates as electron donors difluoro bromamide acceptors generate complex. This is a promising photochemical method advantages such mild conditions, simple operation, being metal-free, excellent functional group tolerance.

Language: Английский

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Indium-catalyzed reductive synthesis of 4-Pyrrolyl-N-Methyl-Indazoles: DFT, molecular docking, and ADME-tox studies for antibacterial and anticancer drug discovery

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1340, P. 142486 - 142486

Published: May 3, 2025

Language: Английский

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Visible‐light‐mediated synthesis of 2H-indazoles from (2-Bromo-benzylidene)-phenyl-amine derivatives by the Ullmann Goldberg reaction.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134486 - 134486

Published: Jan. 1, 2025

Language: Английский

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An Electrochemical Oxo‐amination of 2H‐Indazoles: Synthesis of Symmetrical and Unsymmetrical Indazolylindazolones

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 30(12)

Published: Dec. 26, 2023

We have established a supporting-electrolyte free electrochemical method for the synthesis of indazolylindazolones through oxygen reduction reaction (eORR) induced 1,3-oxo-amination 2H-indazoles where 2H-indazole is used as both aminating agent well precursor indazolone. Moreover, we merged indazolone and indazole to get unsymmetrical direct cross-dehydrogenative coupling (CDC). This exogenous metal-, oxidant- catalyst-free protocol delivered number multi-functionalized products with high tolerance diverse functional groups.

Language: Английский

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Photo- and Electro-chemical Strategies for Indazole Synthesis

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100116 - 100116

Published: Dec. 1, 2024

The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential medicinal chemistry and drug discovery, which therefore has attracted sustained attention from synthetic community. Over recent decades, significant progress been achieved both organic photocatalysis electrosynthesis, offering novel approaches for efficient sustainable synthesis various functionalized indazoles. This mini-review highlights emerging methodological advancements photo-/electro-chemical two common forms indazole, namely 1H- 2H-indazoles, are classified by specific intramolecular bond formation patterns: (1) C-C formation, (2) C-N (3) N-N formation. reaction conditions, representative scopes, mechanistic understandings these protocols emphasized, to elucidate advantages limitations current strategies, with an aim inspire future innovations that may address challenges modern synthesis.Graphical abstractTo create your abstract, type over instructions template box below. Fonts or abstract dimensions should not be changed altered.

Language: Английский

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TMSCl-Promoted Sulfonylation of Propargylic Alcohols with Sodium Sulfinates for the Construction of (E)-1,3-Disulfonylpropenes and (E)-1-Sulfonylpropenols

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 15694 - 15707

Published: Oct. 12, 2024

A direct and novel transformation of propargylic alcohols with sodium sulfinates for the regio- stereoselective synthesis (

Language: Английский

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