The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
A novel Cu/Pd-catalyzed domino radical cyclization and C-H carbonylation of α-bromocarbonyls has been developed, which enables the rapid incorporation CO unit into polycyclic quinolin-2(1
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(24), P. 17521 - 17526
Published: Nov. 22, 2023
An efficient and environmentally friendly electrochemical synthesis of phosphorylated oxindoles indolo[2,1-a]isoquinolin-6(5H)-ones mediated by readily available Cp2Fe has been developed, which illustrated a broad substrate scope diverse functional group compatibility. This protocol featured an external oxidant-free process was at room temperature, proposed to be driven the anodic oxidation Cp2Fe.
Language: Английский
Citations
9
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(4), P. 1478 - 1488
Published: Jan. 17, 2025
Herein, we present a copper-catalyzed, three-component intermolecular 1,4-alkylarylation of 1,3-enynes with ethers and aryl boronic acids. This method, driven by α-C(sp3)-H functionalization the oxygen atom in ethers, regioselectively produces various tetrasubstituted allenes from simple, readily available precursors. Key features include mild reaction conditions simple catalytic system.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 21, 2025
The efficient construction of a C-S bond is one the important topics in organic synthesis. In this work, cross-dehydrogenative coupling reaction between ether and thiophenols or thiols under electrochemical conditions was studied, acetal-O,S products were obtained moderate to good yields. A free radical mechanism proposed. provided simple protocol for formation C(sp3)-S bonds transition-metal- chemical oxidant-free conditions, will have application prospect synthesis drug
Language: Английский
Citations
0
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(37), P. 7618 - 7622
Published: Jan. 1, 2024
A novel visible-light-driven photoredox-catalyzed cascade bicyclization of 1,7-enynes with aqueous sulfoxonium ylides is reported. The reaction highly chemoselective three new C-C bonds, two rings, and an all-carbon quaternary stereocenter constructed in a one-pot fashion. This mild protocol features remarkably broad substrate scope good functional group tolerance, providing general practical approach to access various cyclopenta[
Language: Английский
Citations
2
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(9), P. 6292 - 6305
Published: April 16, 2024
Presented herein is an effective and concise synthesis of acyl cyclopentaquinolinone derivatives via the cascade reactions N-(o-ethynylaryl)acrylamides with α-diazo carbonyl compounds. The formation product involves a visible light-induced radical from compound followed by its addition onto acrylamide moiety to trigger double annulation, single-electron oxidation, β-elimination. To our knowledge, this first example in which scaffold was constructed along introduction group under light irradiation conditions. Compared literature methods for similar purpose, newly developed protocol has advantages such as readily accessible substrates, mild reaction conditions, valuable products, synthetic procedure, high sustainability. With all these merits, method expected find wide applications construction related heterocyclic skeletons.
Language: Английский
Citations
1
Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(7)
Published: April 17, 2024
Abstract A novel alkenylation reaction between N ‐hydroxyphthalimide (NHPI) esters and alkenyl sulfones is reported. It undergoes the formation of electron donor‐acceptor (EDA) complex a series alkenes are obtained in good to excellent yields. has advantages simple operation, mild conditions, metal‐free.
Language: Английский
Citations
1
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(13), P. 9686 - 9694
Published: June 22, 2024
We have established an efficient ruthenium(II) and iodine anion cocatalyzed dihalogenation cascade cyclization of internal alkyne-tethered cyclohexadienones, which stereoselectively afforded numerous products with a bioactive hydrobenzofuran skeleton in high yields under mild conditions. In this transformation, the reaction pathway was determined by concentration electrophilic reagent, also provided strategy for control selectivity. Furthermore, method features use 1,2-dihaloroethane as halogen source via catalyst.
Language: Английский
Citations
1
Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 13(1)
Published: Nov. 22, 2023
Abstract Without an additional activator, the visible‐light‐catalyzed denitroalkylation of β ‐nitrostyrenes and alkyl boronic acids is reported. The efficient coupling cyclic secondary with various aryl nitroolefins realized, which gives olefins in 47–87 % yields. A possible mechanism involving fact that nitrite released from ‐nitrostyrene upon irradiation further activates to generate radicals proposed based on control experiments a literature survey.
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13678 - 13690
Published: Sept. 6, 2024
Herein, a visible-light-promoted radical cascade cyclization of heterocyclic ketene aminals (HKAs) and thiocyanates was developed to access functionalized fused 2-iminothiazolines. This novel reaction can be realized under only visible-light irradiation without the help external photocatalysts, oxidants, additives. These multicomponent reactions demonstrate excellent selectivity for
Language: Английский
Citations
0