Cited by Photoinduced Ag-Mediated Azaspirocyclic Approach Involves Cyclization and Dearomatization

Visible-Light-Mediated Cascade 1,4-Hydrogen Atom Transfer versus Dearomative Spirocyclization of N-Benzylacrylamides: Divergent Access to Functionalized γ-Ketoamides and 2-Azaspiro[4.5]decanes DOI

Chandra Shekhar Nishad, Ashish Kumar, Kamaldeep Kaur

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Visible-light-driven metal- and photocatalyst-free cascade 1,4-HAT dearomative spirocyclization of N-benzylacrylamides are described for sustainable synthesis a variety pharmaceutically important γ-ketoamides 2-Azaspiro[4.5]decanes in one pot good to excellent yields. Readily accessible nontoxic materials, expensive Ir or Ru mild conditions, functional group tolerance, operational simplicity, scalability enhance the practical value this protocol. Mechanistic studies reveal that acyl radicals generated from α-oxocarboxylic acids trigger rare spirocyclization. The synthetic potential environmentally benign method is further showcased by late-stage functionalization drug molecules, amino acid, peptides.

Language: Английский

Citations

Mn(OAc)3 promoted radical cyclization of vinyl isocyanides: Synthesis of isoquinoline-1-sulfonates and derivatives DOI

Xin Gu, Yan Zhang, Ruiming Zhang

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155629 - 155629

Published: May 1, 2025

Language: Английский

Citations

All-aqueous microfluidic printing of multifunctional bioactive microfibers promote whole-stage wound healing DOI

Feng-Lan Xu,

Wentao Sun, Wenyuan Ma

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 234, P. 113720 - 113720

Published: Dec. 21, 2023

Language: Английский

Citations

Electrochemical selenylative ipso-Annulation of N-benzylacrylamides to seleno-azaspiro[4.5]decadienones DOI

Chada Raji Reddy,

Jannatul Islam,

Thallamapuram Nagendraprasad

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(30), P. 6141 - 6148

Published: Jan. 1, 2024

Construction of seleno azaspiro[4.5]decadienones using an electrochemical approach is achieved via domino selenylation/ ipso -annulation.

Language: Английский

Citations

Radical Cascade Annulation of Biphenyl Acrylamides to Dibenzoazepinones: Experimental and DFT Studies DOI

Raju Dupud,

Ramakrishnan Thushara,

Karthik Kumar Merugu

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(31)

Published: June 6, 2024

Abstract An efficient method for the conversion of biphenyl acrylamides to dibenzoazepinones with −SCF 3 incorporation is described. This operationally simple radical cascade reaction employs CAN as an oxidant and exhibits good functional group tolerance. Substrates featuring −OCH , −CH −Br or −Cl at para ‐position aromatic ring a preference ipso ‐cyclization due intervention DMSO in reaction. Density theory (DFT) calculations provide valuable insights into reaction's energetics product selectivity.

Language: Английский

Citations

Manganese(iii) acetate in organic synthesis: a review of the past decade DOI

Jian Wang, Yan Zhang, Yongqiang Zhou

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6850 - 6917

Published: Jan. 1, 2024

In this review, we summarize the latest developments and applications of Mn(OAc) 3 in organic synthesis over past decade, focusing on efforts to achieve milder reaction conditions while expanding scope possibilities.

Language: Английский

Citations

Photoinduced Ag-Mediated Azaspirocyclic Approach Involves Cyclization and Dearomatization DOI

Ming Li,

Dong‐Yu Miao,

Fan Gao

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

A visible-light-promoted protocol for azaspirocyclic synthesis from

Language: Английский

Citations