Zeitschrift für Naturforschung B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 3, 2024
Abstract
A
practical
and
efficient
synthetic
route
to
construct
a
variety
of
3-halochromones
has
been
realized
using
Selectfluor
reagent
as
fluorine
source,
or
Selectfluor-copper(I)
halide
combination
halogen
source
under
mild
conditions.
This
reaction
proceeds
via
sequence
electrophilic
cation
addition,
cyclization
leading
broad
range
in
good
excellent
yields
short
period
time.
Additionally,
the
utilization
commercially
available
cost-effective
copper(I)
renders
this
system
highly
practical.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(56), P. 7228 - 7231
Published: Jan. 1, 2024
A
visible-light-induced
K
2
S
O
8
-promoted
cascade
sulfonation/cyclization
reaction
to
afford
a
series
of
sulfonated
quinolino[2,1-
b
]quinazolinones
has
been
developed
under
mild
conditions.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(16), P. 12739 - 12745
Published: Jan. 1, 2025
A
mild
and
effective
visible-light-induced
decarboxylative
radical
cascade
reaction
of
olefin-containing
imidazoles
α-fluorinated
carboxylic
acids,
has
been
developed
to
afford
monofluoromethylated
or
aryldifluoromethylated
polycyclic
imidazoles.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 3525 - 3537
Published: Feb. 16, 2024
A
photochemical
approach
toward
RCOCF2-substituted
pyrrolo[1,2-a]indolediones
was
developed
by
the
radical
cascade
difluoroalkylation/cyclization
reaction
of
unactivated
1-acryloyl-2-cyanoindoles
with
ethyl
iododifluoroacetate
or
iododifluoramides
under
visible-light
irradiation.
This
transition-metal-
and
photosensitizer-free
protocol
afforded
diverse
difluoroalkylated
in
moderate
to
good
yields
mild
conditions.
Most
appealingly,
can
proceed
smoothly
sunlight
irradiation,
which
opens
a
new
avenue
pyrrolo[1,2-a]indolediones.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(46)
Published: Aug. 9, 2024
Abstract
Given
the
prevalence
of
pyridine
motifs
in
FDA‐approved
drugs,
selective
fluoroalkylation
pyridines
and
quinolines
is
essential
for
preparing
diverse
bioisosteres.
However,
challenges
are
often
faced
with
conventional
Minisci
reactions
achieving
precise
regioselectivity
owing
to
competing
reaction
sites
limited
availability
fluoroalkyl
radical
sources.
Herein,
we
present
a
light‐driven,
C4‐selective
azines
utilizing
N‐aminopyridinium
salts
readily
available
sulfinates.
Our
approach
employs
electron
donor‐acceptor
complexes,
highly
under
mild
conditions
without
an
external
photocatalyst.
This
practical
method
not
only
enables
installation
CF
2
H
groups
but
also
allows
incorporation
‐alkyl
functional
entities,
surpassing
limitations
previous
methods.
The
versatility
pathway
further
demonstrated
through
straightforward
three‐component
involving
alkenes
[1.1.1]propellane.
Detailed
experimental
computational
studies
have
elucidated
origins
regioselectivity,
providing
profound
insights
into
mechanistic
aspects.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 13, 2024
Dearomatization
approaches
are
attractive
for
their
abilities
to
transform
simple,
planar
arenes
into
complex,
three-dimensional
architectures.
In
particular,
visible-light
driven
dearomatization
strategies
significant
because
of
mild,
green,
and
sustainable
nature,
enabling
the
fabrication
new
chemical
bonds
via
an
electron
transfer
or
energy
process.
Indole
compounds,
being
potentially
bioactive
readily
accessible,
can
be
employed
efficiently
as
building
blocks
constructing
diverse
annulated
frameworks
under
photocatalysis.
Highly
stereoselective
radical
cascade
reactions
appropriate
indole
systems
provide
complex
cyclic
scaffolds
bearing
multiple
stereocenters.
fact,
past
few
years
have
witnessed
renaissance
dearomative
cycloadditions
indoles
visible-light-induced
The
present
review
highlights
recent
advances
(2019–mid
2024)
in
visible-light-driven
annulation
leading
formation
polycyclic
indolines,
including
angularly
fused
spiro
indolines.
Most
described
this
providing
quick
access
desired
products.
Additionally,
characteristic
reaction
mechanisms
offered
understand
how
show
distinctive
reactivity
photocatalytic
conditions.
The
present
review
focuses
on
recent
progress
(2020–2024)
in
the
visible-light-driven
decarboxylative
cyclization
of
various
carboxylic
acid
derivatives
for
constructing
carbo-/heterocycles.
