Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015–2024)
Mohd Rashid,
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Shivani Kasana,
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Vaibhav Nigam
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et al.
Molecular Diversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Language: Английский
Mechanochemically Induced Thianthrenium Salts-Based Arylation of Diverse Heterocyclic Scaffolds
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(34), P. 12808 - 12818
Published: Aug. 15, 2024
Herein,
a
mechanochemically
triggered
C–H
arylation
of
coumarins,
quinoline-N-oxides,
and
uracil
molecules
with
aryl
thianthrenium
salts
is
described.
Aryl
are
primarily
acknowledged
for
their
expedient
reusability
adherence
to
atom
economy
principles.
Mechanistic
studies
suggested
that
mechanical
stress
promoted
the
homolytic
scission
C–S
bond
salts,
forming
radical
intermediate.
Later,
intermediate
engaged
in
addition
reaction
above
heterocycles,
leading
desired
products
good
yields.
This
versatile
protocol
accommodates
wide
range
functional
groups
facilitates
synthesis
bioactive
compounds
drug
molecules.
Language: Английский
Mechanochemical Radical Transformations in Organic Synthesis
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
Abstract
Organic
synthesis
has
historically
relied
on
solution‐phase,
polar
transformations
to
forge
new
bonds.
However,
this
paradigm
is
evolving,
propelled
by
the
rapid
evolution
of
radical
chemistry.
Additionally,
organic
witnessing
a
simultaneous
resurgence
in
mechanochemistry,
formation
bonds
solid‐state,
further
contributing
shift
status
quo.
The
aforementioned
advances
chemistry
have
predominantly
occurred
solution
phase,
while
majority
mechanochemical
feature
transformations.
Herein,
we
discuss
rapidly
advancing
area
synthesis:
reactions.
Solid‐state
reactions
offer
improved
green
metrics,
better
reaction
outcomes,
and
access
intermediates
products
that
are
difficult
or
impossible
reach
solution.
This
review
explores
these
context
small
molecule
synthesis,
from
early
findings
current
state‐of‐the‐art,
underscoring
pivotal
role
solid‐state
likely
play
sustainable
chemical
synthesis.
Language: Английский
Immobilization of Ni nanoparticles on pyridine-functionalized MWCNTs for indirect synthesis of benzimidazoles and quinazolinones, and their molecular docking studies as effective inhibitors of α-glucosidase
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1319, P. 139508 - 139508
Published: Aug. 3, 2024
Language: Английский