Photoinduced catalyst-free difluoromethylation–cyclization of indole derivatives via electron donor–acceptor complexes under visible light

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(20), P. 5762 - 5768

Published: Jan. 1, 2024

A novel catalyst-free photoinduced difluoromethylation–cyclization via electron donor–acceptor (EDA) complexes was developed for the synthesis of fluorinated compounds.

Language: Английский

Photo‐Induced Difluoromethylation‐Cyclization of Indoles Using Tetrazole Sulfone Reagent Under Visible Light

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(24)

Published: June 24, 2024

Abstract Polycyclic indoles are prevailed in natural products, pharmaceuticals and biologically active compounds. Herein is described photo‐induced difluoromethylation‐cyclization of N ‐alkene tethered to synthesis tetrahydropyrido[1,2‐ a ]indole using 5‐((difluoromethyl)sulfonyl)‐1‐phenyl‐1H‐tetrazole as CF 2 H radical source. This photochemical reaction tolerates an array functional groups like ester, cyano, ketone, halide, ether, aldehyde heteocycles. Mechanistic experiments indicated that the difluoromethyl single electron transfer were involved.

Language: Английский

Application of Difluoromethyl Isosteres in the Design of Pesticide Active Molecules

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Difluoromethyl (CF

Language: Английский