Synthesis of azaflavanones and alpha-ylidene azaflavanones DOI
Erick M.C. Pinheiro,

Rafael P. R. F. de Oliveira,

Sandro J. Greco

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 167, P. 134295 - 134295

Published: Oct. 10, 2024

Language: Английский

FeCl3-Catalyzed Oxidative Diselenylation of Pyrrole-tethered Indoles DOI
Jing Zhou,

Xue Sheng,

Man Jiang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A mild and efficient FeCl 3 -catalyzed oxidative diselenylation of pyrrole-tethered indoles has been achieved by using RSeSeR as the source selenium m -chloroperoxybenzoic acid ( CPBA) oxidant (yields 17–70%).

Language: Английский

Citations

0
Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization DOI
Wenyan Xu,

Chengwei Zheng,

Mu Chen

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

A green, efficient, and environmentally friendly electrochemical strategy was developed for synthesizing a series of selenoheterocyclic compounds. The antitumor activities these compounds were evaluated, revealing that 4o, 5n, 5o demonstrated remarkable efficacy. These effectively inhibited lung cancer by inducing cell apoptosis, causing DNA damage, suppressing the progression epithelial-mesenchymal transition. Notably, compound identified as first inhibitor DEAD-box helicase 10 (DDX10). An in vivo xenograft assay further confirmed therapeutic potential 5o, demonstrating tumor growth inhibition rates 60%, 78%, 88% at doses 5 mg/kg, 20 respectively. This study highlights promising chemotherapeutic agent effective treatment cancer.

Language: Английский

Citations

0
Electrochemically promoted selenocyclization for the synthesis of organoselenyl isoxazoles DOI
Nan Sun, Zhi Qiao,

Jiamin Li

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(19), P. 10240 - 10246

Published: Jan. 1, 2024

Herein, we report a general and sustainable electrochemically promoted oxidative selenocyclization protocol for the synthesis of organoselenyl isoxazoles from 2-alkyn-1-one O -methyloximes diorganyl diselenides.

Language: Английский

Citations

2
CuI-Catalyzed Selenylation of Pyrrolo[2,1-a]isoquinolines and Other Electron-Rich Heteroarenes DOI
Jing Zhou,

Jiayi Han,

Yu Xin

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

We have established a mild CuI-catalyzed selenylation of pyrrolo[2,1-

Language: Английский

Citations

1
Electrochemically Driven Metal-Free Synthesis of Benzylic Thioethers via C-S Cross-Coupling DOI

Ming-Qiu-Hao Fu,

Yan‐Hong He, Zhi Guan

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6790 - 6796

Published: Jan. 1, 2024

An electrochemically driven C–S radical–radical cross-coupling reaction between benzyl halides and disulfides for the synthesis of benzylic thioethers has been developed under environmentally friendly mild conditions.

Language: Английский

Citations

1
Electrochemical Synthesis of 4‐Selenylated Oxazolones via Oxyselenylation of Ynamides DOI Open Access
Jinhui Cai,

Kaili Cen,

Weishuang Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

Abstract Electrosynthesis of selenylated‐oxazolone derivatives via cascade selenylation/cyclization ynamides was disclosed. A series diaryl diselenides, dialkyl and heteroaryl‐substituted tolerated in this protocol delivered 4‐selenyloxazolones 28–83% yields. The scale‐up reaction the oxidation performed to showcase practicability method. Furthermore, mechanistic experiments indicated that a cationic pathway instead radical probably involved.

Language: Английский

Citations

1
Zn(OTf)2-catalyzed intra- and intermolecular selenofunctionalization of alkenes under mild conditions DOI Creative Commons

Cong Qi,

Zhaogong Lu,

Yuyang Gu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(32), P. 23147 - 23151

Published: Jan. 1, 2024

Zn(OTf)2-catalyzed intra- and intermolecular selenofunctionalization of alkenes was achieved with electrophilic N-phenylselenophthalimide. This method provides straightforward efficient access to various seleno-substituted heterocycles vicinal Se heteroatom-disubstituted molecules under mild conditions. reaction is compatible substrates/functional groups, preliminary studies on the mechanistic were also conducted.

Language: Английский

Citations

0
Electrochemical Oxidative Cross-Coupling and Annulation for Functionalized Heterocycles DOI
Xinwei Hu, Zhixiong Ruan

Topics in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 37 - 53

Published: Jan. 1, 2024

Language: Английский

Citations

0
Electrochemical Selenocyclization of N-Alkyl anilines: Access to 3-Selenyl quinolines DOI

Longqiang Zhao,

Huimin Li,

Mengyu Peng

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134257 - 134257

Published: Sept. 1, 2024

Language: Английский

Citations

0
Synthesis of azaflavanones and alpha-ylidene azaflavanones DOI
Erick M.C. Pinheiro,

Rafael P. R. F. de Oliveira,

Sandro J. Greco

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 167, P. 134295 - 134295

Published: Oct. 10, 2024

Language: Английский

Citations

0