An Innovative Aggregation-Induced Emission-Based NIR Fluorescent Probe for Visualizing Carboxylesterases in Living Cells, Zebrafish and Tumor-Bearing Mice DOI Open Access
Chao Gao, DanDan Chen, Huwei Liu

et al.

Published: June 19, 2024

In human body, carboxylesterases (CEs) play the crucial roles in xenobiotic metabolism and lipid homeostasis. But abnormal CEs expression is highly associated with some diseases, such as hyperlipidemia, diabetes liver cancer. Therefore, it of great significance to develop an efficient tool for accurate detection living organisms. Herein, innovative near-infrared (NIR) fluorescent probe TTAP−AB has been designed based on aggregation-induced emission (AIE) mechanism. This exhibits rapid response (2 min), excellent sensitivity (limit = 8.14×10−6 U/mL), high selectivity towards CEs. Additionally, owing good biocompatibility, enables monitor dynamic changes level under drug-induced modulation cells zebrafish. More importantly, successfully employed image tumor assist resection by real-time monitoring CEs, indicating that promising guide cancer surgery. can not only enrich strategies biological systems, but also potential clinical imaging applications, including medical diagnosis, preclinical research, imaging-guided

Language: Английский

Rational design of a near-infrared fluorescent probe for rapid monitoring of carboxylesterase in live cells and drug-induced liver injury mice DOI

W Xing,

Kaili Yang,

Yonglong Zhu

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1346, P. 343782 - 343782

Published: Feb. 8, 2025

Language: Английский

Citations

0
An Innovative Aggregation-Induced Emission-Based NIR Fluorescent Probe for Visualizing Carboxylesterases in Living Cells, Zebrafish, and Tumor-Bearing Mice DOI Creative Commons
Chao Gao, Guojun Chen, Huwei Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3660 - 3660

Published: Aug. 2, 2024

In the human body, carboxylesterases (CEs) play crucial roles in xenobiotic metabolism and lipid homeostasis. But abnormal expression of CEs is highly associated with some diseases, such as hyperlipidemia, diabetes, liver cancer. Therefore, it great importance to develop an efficient tool for accurate detection living organisms. Herein, innovative near-infrared (NIR) fluorescent probe,

Language: Английский

Citations

1
An Innovative Aggregation-Induced Emission-Based NIR Fluorescent Probe for Visualizing Carboxylesterases in Living Cells, Zebrafish and Tumor-Bearing Mice DOI Open Access
Chao Gao, DanDan Chen, Huwei Liu

et al.

Published: June 19, 2024

In human body, carboxylesterases (CEs) play the crucial roles in xenobiotic metabolism and lipid homeostasis. But abnormal CEs expression is highly associated with some diseases, such as hyperlipidemia, diabetes liver cancer. Therefore, it of great significance to develop an efficient tool for accurate detection living organisms. Herein, innovative near-infrared (NIR) fluorescent probe TTAP−AB has been designed based on aggregation-induced emission (AIE) mechanism. This exhibits rapid response (2 min), excellent sensitivity (limit = 8.14×10−6 U/mL), high selectivity towards CEs. Additionally, owing good biocompatibility, enables monitor dynamic changes level under drug-induced modulation cells zebrafish. More importantly, successfully employed image tumor assist resection by real-time monitoring CEs, indicating that promising guide cancer surgery. can not only enrich strategies biological systems, but also potential clinical imaging applications, including medical diagnosis, preclinical research, imaging-guided

Language: Английский

Citations

0