The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Herein,
we
report
a
sustainable
and
efficient
method
for
the
synthesis
of
structurally
diverse
phthalimidines
from
2-formylbenzoic
acid
primary
amines
using
an
iridium-catalyzed
reductive
lactamization
strategy.
The
advantages
this
method,
such
as
use
water–ethanol
solvent,
broad
substrate
scope,
high
catalyst
efficiency
(S/C
up
to
10000),
good
scalability,
easy
purification,
enable
it
be
practical
approach
phthalimidines.
It
is
suggested
that
iridium
hydride
formation
involved
in
rate-limiting
step.
Synthetic
applications
late-stage
functionalization
medicinally
relevant
molecules
are
also
demonstrated.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
study
reports
a
photocatalytic
nitrene
transfer
reaction
of
1,3-dicarbonyl.
A
broad
range
substrates
and
iodinanes
are
shown,
enabling
direct
C–H
functionalization
without
the
need
for
pre-formed
nucleophilic
enolate
equivalents.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
The
first
example
of
heterogeneous
photoredox-catalyzed
fluoroalkylation
4H-pyrido[1,2-a]pyrimidin-4-ones
has
been
developed.
With
low-cost
commercial
g-C3N4
as
the
recyclable
photocatalyst
and
cheap
sodium
fluoroalkyl
sulfonates
source,
a
variety
fluoroalkylated
pyridopyrimidinones
were
constructed
in
moderate
to
high
yields.
present
reaction
can
be
easily
scaled
up
with
good
efficiency,
catalytic
system
reused
5
times
slight
loss
activities.
Furthermore,
biological
activity
synthesized
compounds
was
preliminarily
investigated.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Herein,
the
first
example
of
self-catalyzed
sono-photoinduced
carbon-carbon
bond
formation
was
described.
Combining
advantages
phototriggered
self-catalysis
and
ultrasonic
catalysis,
a
wide
range
3-arylquinoxalin-2(1
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
A
100%
atom
economical
construction
of
hydroxyalkylated
N-heteroarenes
through
decatungstate-catalyzed
tandem
cyclization/self-hydrogenation
isocyanides
and
aldehydes
under
exogenous
hydrogen
reagent-
byproduct-free
conditions
was
developed.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 27, 2024
Abstract
With
Ag/g‐C
3
N
4
semiconductor
as
the
heterogeneous
photocatalyst,
visible
light
promoted
synthesis
of
unsymmetric
diaryl
chalcogenides
could
be
achieved
under
additive‐free
and
mild
conditions.
A
series
were
generated
in
good
to
excellent
yields
with
high
functional
group
tolerance.
The
photocatalyst
is
easily
recovered
from
reaction
mixture
reused
at
least
5
times,
opening
way
for
larger‐scale
industrial
applications
this
type
photocatalytic
bond‐forming
reactions.
