Organic & Biomolecular Chemistry,
Journal Year:
2018,
Volume and Issue:
16(33), P. 6025 - 6034
Published: Jan. 1, 2018
An
efficient
three-component
one-pot
[3
+
2]
cycloaddition
of
isatins,
1,2,3,4-tetrahydroisoquinolines
and
methyleneindolinones
has
been
developed.
This
reaction
proceeded
in
a
highly
diastereoselective
manner
to
afford
wide
range
pyrrolo[1,2-a]isoquinoline-based
bispirooxindoles
up
91%
yields.
Additionally,
gram-scale
experiment
some
chemical
transformations
were
conducted.
RSC Advances,
Journal Year:
2021,
Volume and Issue:
11(13), P. 7146 - 7179
Published: Jan. 1, 2021
Spirooxindoles
are
used
as
anticancer-,
antiviral-,
antimicrobial
agents
etc.
The
use
of
transition
metals
catalysts
for
the
synthesis
spirooxindoles
is
advancing
rapidly.
Here,
we
focus
on
recent
advances
in
metal-catalyzed
spirooxindoles.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(7), P. 1847 - 1866
Published: Jan. 1, 2023
The
aza-Friedel–Crafts
(aza-FC)
reaction
is
a
very
powerful
tool
for
forming
C–C
and
C–N
bonds,
based
on
an
acid-catalyzed
addition
of
electron-rich
aromatic
compounds
to
imines.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(5), P. 1314 - 1321
Published: Jan. 1, 2024
A
new
class
of
chiral
bipyridine-2NO
ligands,
which
incorporate
the
advantages
both
bipyridine
skeleton
and
pyrroloimidazolone-based
N
-oxide
moiety,
was
developed.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(10)
Published: Jan. 9, 2024
Abstract
We
present
the
first
example
of
electrocatalytic
three‐component
annulation–iodosulfonylation
indole‐tethered
1,6‐enynes
with
arylsulfonyl
hydrazides
and
KI
for
accessing
various
iodosulfonated
pyrrolo[1,2‐
a
]indoles
in
moderate
to
excellent
yields
high
stereospecificity.
This
electrosynthesis
opens
new
avenues
construction
skeleton
good
functional
group
compatibility
under
environmentally
benign
condition.
Based
on
control
experiments
cyclic
voltammetry
data,
we
suggested
plausible
reaction
mechanism
which
included
anodic
oxidation,
homolysis
iodide,
radical
addition,
5
‐
exo
dig
cyclization,
coupling
or
nucleophilic
attack
iodide
ions
cascade.
Chemical Communications,
Journal Year:
2017,
Volume and Issue:
53(81), P. 11201 - 11204
Published: Jan. 1, 2017
A
TfOH-catalyzed
highly
diastereoselective
Michael
addition/ketalization
sequence
of
3-hydroxyoxindoles
and
ortho-hydroxychalcones
was
developed,
leading
to
biologically
important
bridged
ketal
spirooxindoles
in
moderate
excellent
yields.
Moreover,
some
chemical
transformations
were
carried
out
further
extend
the
structural
complexity
diversity.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(5), P. 1158 - 1164
Published: Jan. 10, 2024
Abstract
A
visible‐light‐promoted
cascade
difluoromethylation/cyclization
reaction
to
access
various
difluoromethylated
pyrrolo[1,2‐
a
]indolediones
was
developed
using
difluoromethyltriphenylphosphonium
bromide
salt
as
the
difluoromethylating
reagent.
possible
radical
mechanism
has
been
investigated
and
proven
single
electron
transfer
(SET)
procedure.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(4), P. 1688 - 1695
Published: Jan. 1, 2024
This
work
diversified
the
Py-2NO
ligand
library
recently
developed
by
our
group
and
further
expanded
application
of
chiral
ligands
in
asymmetric
catalysis.
The Journal of Organic Chemistry,
Journal Year:
2018,
Volume and Issue:
83(7), P. 3679 - 3687
Published: March 13, 2018
The
first
highly
diastereoselective
Michael
addition/condensation/Friedel–Crafts
alkylation
cascade
reaction
of
3-indolyl-substituted
oxindoles
with
ortho-hydroxychalcones
was
established,
which
afforded
a
wide
range
polycyclic
indole-bridged
chroman
spirooxindoles
novel
and
complex
scaffolds
in
moderate
to
excellent
yields.
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(16), P. 10209 - 10220
Published: July 18, 2019
The
present
paper
reports
a
highly
stereoselective
synthesis
of
spirooxindole-fused
spiropyrazolones
through
the
asymmetric
[3
+
2]
cyclization
reaction
2-(1-methyl-2-oxoindolin-3-yl)malononitriles
with
unsaturated
pyrazolones
under
mild
conditions.
With
only
1
mol
%
bifunctional
squaramide
catalyst,
series
chiral
dispirocyclic
pyrazolone
derivatives
were
attained
in
high
yields
(85–97%)
excellent
stereoselectivities
(up
to
>99%
ee
and
all
cases
>20:1
dr).
Moreover,
gram-scale
further
transformation
products
also
demonstrated.
