Organic & Biomolecular Chemistry,
Journal Year:
2018,
Volume and Issue:
16(33), P. 6025 - 6034
Published: Jan. 1, 2018
An
efficient
three-component
one-pot
[3
+
2]
cycloaddition
of
isatins,
1,2,3,4-tetrahydroisoquinolines
and
methyleneindolinones
has
been
developed.
This
reaction
proceeded
in
a
highly
diastereoselective
manner
to
afford
wide
range
pyrrolo[1,2-a]isoquinoline-based
bispirooxindoles
up
91%
yields.
Additionally,
gram-scale
experiment
some
chemical
transformations
were
conducted.
Journal of Heterocyclic Chemistry,
Journal Year:
2019,
Volume and Issue:
56(9), P. 2318 - 2332
Published: Aug. 16, 2019
In
current
scenario,
heterocyclic
compounds'
role
in
medicinal
chemistry
has
been
tremendously
increased
as
they
possess
wide
number
of
pharmacological
activities.
One
the
common
heterocycles
include
indole
skeleton
with
well‐established
biological
significance
field
chemistry.
Fusion
nucleus
pyrrole
heterocycle
constitutes
pyrroloindole
scaffold,
which
further
modifies
existing
properties
alone.
Pyrroloindole
is
a
privileged
scaffold
found
various
types
bioactive
entities
including
natural
compounds
and
exhibits
variety
activities
like
muscle
relaxant,
antifungal,
antitumor,
antibiotic.
Therefore,
it
considered
attractive
template
for
drug
discovery.
From
several
years,
numbers
synthetic
strategies
have
reported
synthesis
its
derivatives,
also
such
amauromine,
yuremamine,
chimonanthines.
Here,
this
review,
we
tried
to
compile
derivatives.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(42)
Published: Aug. 19, 2023
Abstract
To
expand
the
chemical
space
of
chiral
N
‐oxides
and
furan‐containing
ligands,
herein
we
designed
synthesized
a
new
class
rigid‐featured
tertiary
amine‐derived
C
2
‐symmetric
furan‐
,
N′
‐dioxide
(Fu‐2NO)
ligands
from
optically
pure
l
‐prolinamides/hydroxylprolinamides
in
operationally
simple
two
steps
up
to
57
%
overall
yield.
The
newly
developed
Fu‐2NO
possesses
pyrroloimidazolone‐based
as
non‐flat
walls,
afforded
opportunity
for
fine‐tuning
ligand
electronic
conformational
properties
by
judicious
choice
substituent
nonligating
nitrogen
atom.
More
importantly,
can
tolerate
air
moisture
such
that
no
special
handling
is
needed
their
storage,
be
applied
Ni(II)‐catalyzed
asymmetric
Friedel‐Crafts
alkylation
reaction
indole.
Organic & Biomolecular Chemistry,
Journal Year:
2018,
Volume and Issue:
16(33), P. 6025 - 6034
Published: Jan. 1, 2018
An
efficient
three-component
one-pot
[3
+
2]
cycloaddition
of
isatins,
1,2,3,4-tetrahydroisoquinolines
and
methyleneindolinones
has
been
developed.
This
reaction
proceeded
in
a
highly
diastereoselective
manner
to
afford
wide
range
pyrrolo[1,2-a]isoquinoline-based
bispirooxindoles
up
91%
yields.
Additionally,
gram-scale
experiment
some
chemical
transformations
were
conducted.
