Indole Substrates to Carbazole Targets: An Update in the Discovery of an Ideal Synthetic Methodology DOI
Priyanka Behera,

D.S. Ramakrishna,

Suhasini Mohapatra

et al.

Journal of Molecular and Engineering Materials, Journal Year: 2023, Volume and Issue: 11(03n04)

Published: Nov. 15, 2023

Carbazole compounds have been proven to exhibit vital photophysical and biological applications. Even simple carbazole derivatives were showing attractive activities such as antimicrobacterial activity (Glycozoline), antiproliferative (Mukonine), free radical scavenger (Carazostatin), etc. In case of applications, utilized in organic semiconductors, photoconducting polymers, Green host material phosphorescent light-emitting diodes (OLEDs), hole-transporting OLEDs light emitting materials. An account different synthetic methodologies involved the synthesis natural was evaluated based on usage commercially available cheap starting materials Indole. This paper takes into time from 2011 2023. The advanced methods developed 12 principles chemistry Multistep domino reactions, Atom & Step economy protection-free mild reaction conditions, open atmosphere harmless by-products photochemical transformations.

Language: Английский

N-benzyl-N-methyldecane-1-amine derived from garlic ameliorates UVB-induced photoaging in HaCaT cells and SKH-1 hairless mice DOI Creative Commons

Phatcharaporn Budluang,

Ji Eun Kim, Eun Seo Park

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Skin tissue is susceptible to oxidative stress-induced senescence provoked by ultraviolet (UV) exposure in our daily lives, resulting photoaging. Herein, we explore whether N-benzyl-N-methyldecan-1-amine (BMDA) derived from garlic ameliorates UVB-induced To address this issue, HaCaT keratinocytes were exposed UVB irradiation under BMDA treatment. The presence of substantially reduced ROS levels a dose-dependent manner. administration counteracted the β-galactosidase assay. Treatment with also rescued UVB-exposed cells (S phase; 18.3 25.8%) cell cycle arrest, similar level observed untreated normal cells. These findings might support observation that elevated γ-H2AX, DNA damage marker, following administration. Additionally, treatment indirectly melanin synthesis melanocytes since failed inhibit tyrosinase activity, crucial enzyme synthesis. topical application on skin SKH-1 hairless mice diminished wrinkle formation, supported recovered collagen and thickness epidermis dermis, compared those UVB-control mice. Finally, expression inflammatory cytokine transcripts such as TNF-α, IL-1β, IL-4, IL-6 tissues. This finding further Immunofluorescence microscopy, which showed decrease IL-1β during Altogether, mitigates photoaging reducing production, protecting against damage, suppressing it has been proposed an effective anti-photoaging molecule.

Language: Английский

Citations

1
l-Proline catalysed synthesis and in silico studies of novel α-cyano bis(indolyl)chalcones as potential anti-cancer agents DOI Creative Commons
Monika Malik,

N. ROY,

Abeer A. Mohamed

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(6), P. 4593 - 4606

Published: Jan. 1, 2025

Various α-cyano bis(indolyl)chalcones synthesized in excellent yields (up to 95%) were found display good cytotoxicity (IC 50 = 0.9–5.8 μM) and caused apoptosis C4-2 cells.

Language: Английский

Citations

0
A Concise Protocol for the Synthesis of 2-Alkenylindoles through [4+1] Annulation of Aminobenzyl Phosphonium Salts with Acrylaldehydes DOI
Jiacheng Yang,

Mao-Lin Liao,

Ping‐Gui Li

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(17), P. 9295 - 9299

Published: Jan. 1, 2024

A concise and efficient protocol for the synthesis of various 2-alkenylindole derivatives is developed through [4 + 1] annulation starting from aminobenzyl phosphonium salts cinnamaldehydes.

Language: Английский

Citations

2
A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media DOI
Adeleh Moshtaghi Zonouz,

Davoud Moghani

Letters in Organic Chemistry, Journal Year: 2024, Volume and Issue: 21(5), P. 448 - 455

Published: Jan. 24, 2024

Abstract: Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin domino salicylaldehyde derivatives the presence ammonium acetate The advantages present protocol are high yields, short times, mild conditions, operational simplicity, environmentally benign, also there is no need to purification products.

Language: Английский

Citations

1
Synthesis of Branch-Type 3-Allylindoles from N-Alkyl-N-cinnamyl-2-ethynylaniline Derivatives Using π–Allylpalladium Chloride Complex as a Catalyst DOI
Kohei Watanabe,

Keita Nakano,

Hayato Sato

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(11), P. 8111 - 8119

Published: May 10, 2024

The reaction of N-alkyl-N-cinnamyl-2-ethynylaniline derivatives 1 via annulation and aza-Claisen-type rearrangement easily afforded corresponding branch-type 3-allylindoles 2 with high regioselectivities in good yields using π-allylpalladium chloride complex as a catalyst.

Language: Английский

Citations

1
Facile and diverse synthesis of indolyl substituted 4,5,6,7-tetrahydro-4H-indol-4-ones and 1,6-dihydropyrrolo[2,3-c]pyrazol via multi-component reactions DOI
Jing Wang, Lu Yu, Haiying Jiang

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155444 - 155444

Published: Dec. 1, 2024

Language: Английский

Citations

1
Indole Substrates to Carbazole Targets: An Update in the Discovery of an Ideal Synthetic Methodology DOI
Priyanka Behera,

D.S. Ramakrishna,

Suhasini Mohapatra

et al.

Journal of Molecular and Engineering Materials, Journal Year: 2023, Volume and Issue: 11(03n04)

Published: Nov. 15, 2023

Carbazole compounds have been proven to exhibit vital photophysical and biological applications. Even simple carbazole derivatives were showing attractive activities such as antimicrobacterial activity (Glycozoline), antiproliferative (Mukonine), free radical scavenger (Carazostatin), etc. In case of applications, utilized in organic semiconductors, photoconducting polymers, Green host material phosphorescent light-emitting diodes (OLEDs), hole-transporting OLEDs light emitting materials. An account different synthetic methodologies involved the synthesis natural was evaluated based on usage commercially available cheap starting materials Indole. This paper takes into time from 2011 2023. The advanced methods developed 12 principles chemistry Multistep domino reactions, Atom & Step economy protection-free mild reaction conditions, open atmosphere harmless by-products photochemical transformations.

Language: Английский

Citations

2