Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion

Organic & Biomolecular Chemistry, Journal Year: 2021, Volume and Issue: 19(7), P. 1438 - 1458

Published: Jan. 1, 2021

The review highlighted diverse annulations, including nitrogen, oxygen, sulfur heterocycles and carbocylizations via Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation with various arene carbene precursors.

Language: Английский

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Green strategies for transition metal-catalyzed C–H activation in molecular syntheses

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(17), P. 4886 - 4913

Published: Jan. 1, 2021

Sustainable strategies for the activation of inert C–H bonds towards improved resource-economy.

Language: Английский

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Recent Development on Cp*Ir(III)‐Catalyzed C−H Bond Functionalization

ChemCatChem, Journal Year: 2019, Volume and Issue: 12(9), P. 2358 - 2384

Published: Dec. 18, 2019

Abstract Selective functionalization of ubiquitous C−H bonds molecules would provide novel retrosynthetic insights and powerful tools for the rapid construction molecular complexity. In this context, Cp*Ir(III) complexes have exhibited versatile reactivity towards selective conversion bonds, with key features that include use readily transformable raw materials, great selectivity (chemo‐, stereo‐ regio‐), high efficiency, mild reaction conditions they enable late‐stage modification complex molecules. Recently, catalysis has achieved a broad range reactions such as multiple dehydrogenations stereoselective C−X bond formations. These advancements are valuable to organometallic chemists efficient synthesis functionalized architectures.

Language: Английский

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Toward C2-nitrogenated chromones by copper-catalyzed β-C(sp²)–H N-heteroarylation of enaminones

Organic Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 7(9), P. 1107 - 1112

Published: Jan. 1, 2020

The synthesis of C2-nitrogenated chromones has been performed via reactions enaminones and nitrogen nucleophiles based on an unconventional β-C–H bond functionalization a featured chromone annulation enaminones.

Language: Английский

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Transition‐Metal‐Catalyzed C−H Bond Functionalization of Arenes/Heteroarenes via Tandem C−H Activation and Subsequent Carbene Migratory Insertion Strategy

The Chemical Record, Journal Year: 2021, Volume and Issue: 21(12), P. 4088 - 4122

Published: Oct. 14, 2021

Abstract The past decade has witnessed tremendous developments in transition‐metal‐catalyzed C−H bond activation and subsequent carbene migratory insertion reactions, thus assisting the construction of diverse arene/heteroarene scaffolds. Various transition‐metal catalysts serve this purpose provide efficient pathways for an easy access to substituted heterocycles. A brief introduction metal‐carbenes been provided along with key mechanistic underlying coupling reactions. review is a concise knowledge about directing group‐assisted varied arenes/heteroarenes acceptor‐acceptor/donor‐acceptor diazo compounds. also highlights synthesis various carbocycles fused heterocycles through pathways, via C−C, C−N C−O forming mechanism usually involves process, followed by leading coupling.

Language: Английский

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Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity

Mini-Reviews in Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 22(7), P. 1030 - 1063

Published: Nov. 24, 2021

Chromones are the class of secondary metabolites that broadly occur in plant kingdom a noticeable quantity. This rigid bicyclic system has been categorized "as privileged scaffolds compounds" medicinal chemistry. Their wide biological responses have made them an important moiety drug discovery program. review provides updates on various methods synthesis chromones and applications Various synthetic strategies for construction include readily available phenols, salicylic acid its derivatives, ynones, chalcones, enaminones, 2-hydroxyarylalkylketones as starting materials. Synthesis by using metal, metal-free, nanomaterials different other catalysts is herein included. Details diverse activities chromone derviatives, such anti-cancer, antimicrobial, anti-viral, anti-inflammatory, antioxidant, Monoamine Oxidase-B (MAO-B) inhibitors, anti- Alzheimer's agents, anti-diabetic having antihistaminic potential, acting antiplatelet discussed.

Language: Английский

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Cascade in Situ Iodination, Chromone Annulation, and Cyanation for Site-Selective Synthesis of 2-Cyanochromones

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(6), P. 4017 - 4023

Published: March 2, 2023

A facile cascade reaction for the site selective synthesis of 2-cyanochromones is described. By using simple o-hydroxyphenyl enaminones and potassium ferrocyanide trihydrate (K4[Fe(CN)6]3·3H2O) as starting materials I2/AlCl3 promoters, products are furnished via tandem chromone ring formation C–H cyanation. The in situ 3-iodochromone a formal 1,2-hydrogen atom transfer (HAT) process account unconventional selectivity. In addition, 2-cyanoquinolin-4-one has been realized by employing corresponding 2-aminophenyl enaminone substrate.

Language: Английский

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Synthetic Organic “Aquachemistry” that Relies on Neither Cosolvents nor Surfactants

ACS Central Science, Journal Year: 2021, Volume and Issue: 7(5), P. 739 - 747

Published: April 21, 2021

There is a growing awareness of the underlying power catalytic reactions in water that not limited to innate sustainability alone. Some Type III are catalytically accelerated without dissolution reactants and occasionally highly selective, as shown by comparison with corresponding run organic solvents or under solvent-free conditions. Such catalysts diversified, including hydrophilic, lipophilic, even solid catalysts. In this Outlook, we highlight impressive characteristics illustrative catalysis exerted despite immiscibility substrates reveal intrinsic benefits these enigmatic for synthetic chemistry, albeit many details remaining unclear. We hope brief introduction expanding field "aquachemistry" will inspire chemists use platform invent new transformations.

Language: Английский

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Sustainable C–H functionalization under ball-milling, microwave-irradiation and aqueous media

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(6), P. 2296 - 2320

Published: Jan. 1, 2022

This tutorial review gathers landmark work on transition-metal mediated C–H activation reactions using more sustainable approaches. We endeavour to promote and propagate such lines of research, reducing the usage hazardous synthetic routes in chemical synthesis.

Language: Английский

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Recent advances in visible-light-mediated functionalization of olefins and alkynes using copper catalysts

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(57), P. 7850 - 7873

Published: Jan. 1, 2022

Olefins and akynes are synthetically important building blocks in modern organic synthesis. This review highlights the recent developments direct functionalization of olefins alkynes via photoinduced copper-based catalysis.

Language: Английский

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