Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
134(30)
Published: May 5, 2022
Abstract
In
a
ball
mill,
FeBr
3
‐catalyzed
intramolecular
amidations
lead
to
3,4‐dihydro‐2(1
H
)‐quinolinones
in
good
almost
quantitative
yields.
The
reactions
do
not
require
solvent
and
are
easy
perform.
No
additional
ligand
is
needed
for
the
iron
catalyst.
Both
4‐substituted
aryl
β‐substituted
dioxazolones
provide
products
with
high
selectivity.
Mechanistically,
an
electrophilic
spirocyclization
followed
by
C−C
migration
explains
formation
of
rearranged
products.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(8), P. 4270 - 4357
Published: Jan. 1, 2024
Given
the
high
toxicity
of
inorganic
inhibitors,
organic
substances,
primarily
heterocycles,
have
been
proven
to
be
one
most
efficient,
cost-effective,
and
practical
alternatives.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 236 - 236
Published: Jan. 9, 2025
Orthopalladated
derivatives
from
substituted
phenylglycines
[Pd(μ-Cl)(C6H3R1C(R2)(R3)N(R4)2]2
(1)
react
with
halogenating
reagents
(PhICl2,
Br2,
I2)
(2)
to
give
the
corresponding
o-halogenated
amino
acids
C6H3(X)R1C(R2)(R3)N(R4)2
(3).
The
reaction
is
general
and
tolerates
a
variety
of
functional
groups
(R1
R4)
at
aryl
ring,
Cα,
N
atom.
On
other
hand,
PhI(OAc)2
in
presence
alcohols
R5OH
(4)
gives
o-alkoxylated
C6H3(OR5)R1C(R2)(R3)N(R4)2
(5),
also
as
process.
A
partial
loss
enantiomeric
excess
observed
when
starting
phenylglycine
enantiomerically
pure,
this
arising
formation
bridging
azavinylidene
(6)
imine
intermediate
species
(7),
which
were
characterized
by
X-ray
diffraction
methods.
ChemCatChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 31, 2025
Abstract
This
review
provides
an
overview
on
recent
progress
in
mechanochemical
transition
metal
catalyzed
C─H
functionalization.
Solventless
operation
and
enhanced
reaction
efficiency
makes
synthesis
a
more
sustainable
alternative
to
conventional
approaches.
By
including
comparison
between
methods
solvent‐based
protocols,
this
chemists
with
valuable
insights
into
the
relative
sustainability
of
these
solventless
strategies.
enables
informed
decision‐making
when
selecting
for
functionalization
based
specific
needs.
Moreover,
identifies
existing
gaps
discusses
necessary
steps
establish
it
as
mainstream
approach.
bridging
gaps,
can
further
enhance
utility
adoption
methodologies,
contributing
practices
synthetic
chemistry.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(23)
Published: Feb. 7, 2024
Abstract
The
advancement
of
sustainable
chemistry
and
changes
in
the
economy
are
strongly
intertwined.
Reaction
time,
cost
savings,
moderate
temperatures,
generation
fewest
byproducts
frequently
achieved
by
using
catalytic
processes.
Herein,
we
report
C−H
olefination
imidazo[1,2a]
pyridine
carboxamides
with
various
acrylates
presence
Pd
(OAc)
2
O
as
oxidant
aqueous
ethanol
rather
than
non‐ecofriendly
solvents.
activation
features
most
user‐friendly
reaction
conditions,
excellent
yield
well
plenty
substrate
scope
applicable
for
deuteriation
corresponding
heteroarenes
D
O.
Experimental
mechanistic
studies
indicate
that
step
succeeded
after
formation
tetra
coordinated
square
planer
Pd‐substrate
adduct.
Inorganica Chimica Acta,
Journal Year:
2022,
Volume and Issue:
538, P. 120981 - 120981
Published: April 22, 2022
The
replacement
of
conventional
organic
solvents
by
the
so-called
"green
solvents"
is
a
usual
approach
to
more
sustainable
chemical
processes.
Supercritical
carbon
dioxide
(scCO2)
has
been
successfully
regarded
as
candidate
for
such
purpose.
Moreover,
it
possesses
moderate
critical
pressure
and
temperature
conditions
may
be
easily
separated
from
catalytic
system
simple
depressurization.
In
present
work,
new
Zn(II)
coordination
polymer
[Zn(L1)(NMeF)]n·n(NMeF)
(Zn-CP
1)
reported,
being
prepared
solvothermal
reaction
5-{(pyren-4-ylmethyl)amino}isophthalic
acid
(H2L1)
with
Zn(NO3)2·6H2O
in
N-methylformamide
(NMeF).
SCXRD
analysis
revealed
that
Zn-CP
1
1D
double
chain
type
structure.
Its
potential
catalyst
was
studied
Knoevenagel
condensation
benzaldehyde
malononitrile
model
under
mild
conditions,
scCO2
medium.
An
increasing
trend
observed
yield
we
moved
aprotic
(THF)
protic
(EtOH
H2O)
polar
co-solvents,
reaching
full
conversion
case
water.
It
found
scCO2,
absence
co-solvent,
not
most
suitable
medium
this
reaction.
can
recycled
without
considerable
loss
activity;
SEM,
PXRD,
FT-IR
TGA
analyses
indicate
its
high
stability
throughout
process.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(20), P. 7916 - 7933
Published: Jan. 1, 2023
This
review
present
case
studies
analyzed
in
terms
of
waste
production
and
environmental/safety
hazard
aiming
at
quantify
whether
the
adoption
C–H
functionalization
technology
is
actually
most
effective
strategy
compared
to
classic
approaches.
