Terahertz wave alleviates comorbidity anxiety in pain by reducing the binding capacity of nanostructured glutamate molecules to GluA2

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy carry risk side effects. Here, we report terahertz (THz, 10 12 Hz) wave stimulation (THS) technique, exerts nonthermal, long-term modulatory effects neuronal activity by reducing the binding between nano-sized glutamate molecules GluA2, leading to relief comorbid anxiety-like behaviors mice. In mice co-occurring induced complete Freund’s adjuvant (CFA) injection, hyperactivity was observed glutamatergic neurons anterior cingulate cortex (ACC Glu ). Using whole-cell recording ACC slices, demonstrated that THS (34 THz) effectively inhibited excitability . Moreover, molecular dynamics simulations showed reduced number hydrogen bonds bound GluA2. Furthermore, target CFA-treatment suppressed and, as result, alleviated behaviors. Consistently, inhibition chemogenetics mimics THS-induced antinociceptive antianxiety behavior. Together, our study provides evidence for an intervention technique modulating viable clinical treatment strategy anxiety.

Language: Английский

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Terahertz Wave Targeting Modulates the Dedocking of Neurotransmitters with Receptors

Fundamental Research, Journal Year: 2024, Volume and Issue: 5(2), P. 586 - 592

Published: Dec. 10, 2024

Neurotransmitters are essential in regulating the functions of nervous, cardiovascular, endocrine, and various other tissue systems. Neurodegenerative diseases such as Parkinson's disease, depression, Alzheimer's disease involve loss catecholamine neurons. One main challenges is accumulation (CA) metabolites. Reducing metabolic aggregation toxicity transmitter molecules remains an open question. In this work, we proposed a novel physical method, terahertz-triggered dedocking, to unbind ligand that accumulate around receptor proteins, potentially alleviating neurodegenerative diseases. We found electromagnetic stimulation at 44.5 THz successfully dissociates DA from binding sites by breaking weak hydrogen bonds. Using molecular docking, identified multiple for CA neurotransmitter within dopamine D2 (DRD2). also characterized terahertz fingerprints theoretical spectra CAs across 0.5 50 range, revealing their microscopic vibrational modes characteristic peak positions elucidating how specific vibrations influence conformational changes. This finding highlights potential radiation nervous system provides new support neural drug discovery intervention neurological disorders.

Language: Английский

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Terahertz waves promote Ca2+ transport in the Cav2.1 channel

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126039 - 126039

Published: March 1, 2025

Language: Английский

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Terahertz waves facilitate capsaicin expulsion from TRPV1

The Journal of Chemical Physics, Journal Year: 2025, Volume and Issue: 162(18)

Published: May 8, 2025

Transient receptor potential vanilloid 1 (TRPV1) is a critical non-selective cation channel involved in various biological and physiological processes, making it promising drug target for treating multiple diseases. Capsaicin, TRPV1 agonist, widely used to relieve pain by desensitizing the with persistent stimulation. However, initially intolerable burning sensation due activation necessitates use of antagonists deactivate mitigate discomfort, which yet causes thermoregulation disorders. In this study, molecular dynamics simulations reveal that frequency-specific terahertz (THz) waves can promote capsaicin unbinding from TRPV1, suggesting spatiotemporally controlled approach deactivation. The THz wave resonates hydroxyl group head, increasing its rotational kinetic energy promoting rotation. This disrupts key hydrogen bond between residue E570, significantly reducing capsaicin’s affinity TRPV1. Our findings suggest could mimic more flexible way, offering temporal control over recruitment expulsion (i.e., activation, desensitization, deactivation) comfortable relief. addition, work enlightens THz-based, pill-free strategy induced inflammatory ligands activated

Language: Английский

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Terahertz Science and Technology in Astronomy, Telecommunication, and Biophysics

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

This paper reviews recent developments and key advances in terahertz (THz) science, technology, applications, focusing on 3 core areas: astronomy, telecommunications, biophysics. In THz it highlights major discoveries ongoing projects, emphasizing the role of advanced superconducting technologies, including superconductor–insulator–superconductor (SIS) mixers, hot electron boundedness spectroscopy (HEB), transition-edge sensors (TESs), kinetic inductance detectors (KIDs), while exploring prospects field. For telecommunication, discusses progress solid-state sources, new communication technologies operating within band, diverse modulation methods that enhance transmission capabilities. biophysics, focus shifts to physical waves their impact across biological systems, from whole organisms cellular molecular levels, nonthermal effects fundamental mechanisms. review concludes with an analysis challenges perspectives shaping future technology.

Language: Английский

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