Enhancement of the Transdermal Delivery of Nonsteroidal Anti-inflammatory Drugs Using Liposomes Containing Cationic Surfactants

ACS Omega, Journal Year: 2022, Volume and Issue: 7(29), P. 25741 - 25750

Published: July 12, 2022

New hybrid liposomes based on cationic amphiphiles with different structures of the head group (cetyltrimethylammonium bromide (CTAB), 3-hexadecyl-1-hydroxyethylimidazolium (IA-16(OH)), 1-(butylcarbamoyl)oxyethyl-3-hexadecylimidazolium (IAC 16(Bu)), and hexadecylmethylpyrrolidinium (PR-16)) were developed for transdermal administration nonsteroidal anti-inflammatory drugs. The surfactant/lipid compositions studied to obtain stable high functionality. hydrodynamic diameter was ∼110 nm. An admixture surfactants PC improves physicochemical properties vesicles diffusion rate prolongs release Liposomal diclofenac sodium (DS) ketoprofen (KP) tested (using Franz cells) penetration. Drug monitoring 48 h demonstrated that maximum DS KP penetration through synthetic membranes (Strat-M) is characterized by values 255 ± 2 186 3 μg/cm2, respectively. influence surfactant (stability, profile, permeability) shown first time. While drug specificity evident release, permeability increases as follows: conventional < CTAB/PC PR-16/PC IAC-16(Bu)/PC IA-16(OH)/PC both medicines. rat paw edema model used assess effect leader formulation in vivo. It found liposomal are effective relieving edema. should be noted DS-loaded highest therapeutic efficacy compared vesicles.

Language: Английский

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Hydrotropes: Solubilization of nonpolar compounds and modification of surfactant solutions

Journal of Molecular Liquids, Journal Year: 2022, Volume and Issue: 370, P. 120923 - 120923

Published: Nov. 30, 2022

Language: Английский

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Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance

RSC Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 14(9), P. 1603 - 1628

Published: Jan. 1, 2023

Fungal infections cause severe and life-threatening complications especially in immunocompromised individuals. Antifungals targeting cellular machinery cell membranes including azoles are used clinical practice to manage topical systemic fungal infections. However, continuous exposure clinically antifungal agents managing the results development of multi-drug resistance

Language: Английский

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Synthesis, Properties, and Biomedical Application of Dicationic Gemini Surfactants with Dodecane Spacer and Carbamate Fragments

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12312 - 12312

Published: Aug. 1, 2023

A synthesis procedure and aggregation properties of a new homologous series dicationic gemini surfactants with dodecane spacer two carbamate fragments (N,N'-dialkyl-N,N'-bis(2-(ethylcarbamoyloxy)ethyl)-N,N'-dimethyldodecan-1,6-diammonium dibromide, n-12-n(Et), where n = 10, 12, 14) were comprehensively described. The critical micelle concentrations obtained using tensiometry, conductometry, spectrophotometry, fluorimetry. thermodynamic parameters adsorption micellization, i.e., maximum surface excess (Гmax), the area per surfactant molecule (Amin), degree counterion binding (β), Gibbs free energy micellization (∆Gmic), calculated. Functional activity surfactants, including solubilizing capacity toward Orange OT indomethacin, incorporation into lipid bilayer, minimum inhibitory concentration, bactericidal fungicidal concentrations, was determined. Synthesized further used for modification liposomes dual-loaded α-tocopherol donepezil hydrochloride intranasal treatment Alzheimer's disease. have high stability (more than 5 months), significant positive charge (approximately + 40 mV), encapsulation efficiency rhodamine B, α-tocopherol, hydrochloride. Korsmeyer-Peppas, Higuchi, first-order kinetic models to process in vitro release curves Intranasal administration loaded 21 days prevented memory impairment decreased number Aβ plaques by 37.6%, 40.5%, 72.6% entorhinal cortex, DG, CA1 areas hippocampus brain transgenic mice disease model (APP/PS1) compared untreated animals.

Language: Английский

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Russian Journal of General Chemistry, Journal Year: 2023, Volume and Issue: 93(7), P. 1867 - 1899

Published: July 1, 2023

Abstract The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving solubility of hydrophobic bioactives. Further, liposomal vehicles reviewed, both advantages limitations discussed. Literature assay covers up-to-date information about last three five years, although brief background is given pioneer works addressing liposomes their evolution from bench bedside. Final part devoted modern modifications vesicular nanocarriers which can be adapted specific administration way due improved targeting properties, permeability, mucoadhesiveness possibility cross biological barriers. Therein, such kinds transfersomes, niosomes, ethosomes, chitosomes evaluated; separate sections focus formulations, i.e., phytosomes invasomes.

Language: Английский

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New Polyfunctional Biamphiphilic Surfactants Based on Alkylmethylmorpholinium Cation and Dodecyl Sulfate Anion

Colloid Journal, Journal Year: 2024, Volume and Issue: 86(1), P. 64 - 85

Published: Feb. 1, 2024

Language: Английский

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Self-aggregation and antimicrobial activity of cationic benzimidazolium surfactants: Electrolyte effect on the Krafft temperature

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 424, P. 127098 - 127098

Published: Feb. 7, 2025

Language: Английский

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Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1950 - 1950

Published: Sept. 15, 2022

One of the main problems in treatment poisoning with organophosphorus (OPs) inhibitors acetylcholinesterase (AChE) is low ability existing reactivators AChE that are used as antidotes to cross blood-brain barrier (BBB). In this work, modified cationic liposomes were developed can penetrate through BBB and deliver reactivator pralidoxime chloride (2-PAM) into brain. Liposomes obtained on basis phosphatidylcholine imidazolium surfactants. To obtain composition optimized terms charge, stability, toxicity, molar ratio surfactant/lipid was varied. For systems, physicochemical parameters, release profiles substrates (rhodamine B, 2-PAM), hemolytic activity cause hemagglutination evaluated. Screening liposome penetration BBB, analysis 2-PAM pharmacokinetics, vivo reactivation showed readily pass brain reactivate rats poisoned paraoxon (POX) by 25%. first time, an assessment made loaded reduce death neurons brains mice. It shown intravenous administration liposomal significantly POX-induced neuronal hippocampus.

Language: Английский

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Synthesis and interface behaviors of amino acid surfactants with naturally derived branched hydrophobic chains

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 398, P. 124328 - 124328

Published: Feb. 23, 2024

Language: Английский

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Structure-activity correlation for new phosphorylated quaternary ammonium salts: to antimicrobial activity via self-organization

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 700, P. 134820 - 134820

Published: July 14, 2024

Language: Английский

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