Deuterium in drug discovery: progress, opportunities and challenges

Nature Reviews Drug Discovery, Journal Year: 2023, Volume and Issue: 22(7), P. 562 - 584

Published: June 5, 2023

Language: Английский

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A generic approach yields organic solar cells with enhanced efficiency and thermal stability

Aggregate, Journal Year: 2022, Volume and Issue: 4(2)

Published: Nov. 5, 2022

Abstract The use of deuterium are critical for promoting the fundamental understanding aggregate materials and their new functions. Particularly, solution structure conjugated polymers can be hardly resolved without deuteration. However, studies about isotopic effects casting solvents on aggregated structures photovoltaic bulk‐heterojunction blends deficient. Here, impact deuterated thermal behavior, structures, device performance is clearly delineated first time by multiple techniques. enhanced π‐π stacking order highly relevant to relatively poor miscibility with solvents. Benefiting from higher crystallinity optimized morphology processed films, devices able achieve better efficiency notable improvement in stability. Our results highlight polymer systems reveal potential innovative approaches fabricate thermally stable high‐efficiency solar cells.

Language: Английский

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D₂O as an Imperfect Replacement for H₂O: Problem or Opportunity for Protein Research?

The Journal of Physical Chemistry B, Journal Year: 2023, Volume and Issue: 127(38), P. 8086 - 8094

Published: Sept. 18, 2023

D2O is commonly used as a solvent instead of H2O in spectroscopic studies proteins, particular, infrared and nuclear-magnetic-resonance spectroscopy. chemically equivalent to H2O, the differences, particularly hydrogen-bond strength, are often ignored. However, replacing water with can affect not only kinetics but also structure stability biomolecules. Recent experiments have shown that even mesoscopic structures elastic properties biomolecular assemblies, such amyloids protein networks, be very different H2O. We discuss these findings, which probably just tip iceberg, seem call for obtaining better understanding H2O/D2O-isotope effect on water–water water–protein interactions. Such improved may change differences between solvents from an elephant room opportunity research.

Language: Английский

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Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(13)

Published: Feb. 4, 2023

The green revolution in plastics should be accelerated due to growing sustainability concerns. Here, we develop a series of chemically recyclable polymers from the first reported cascade polymerization H2 O, COS, and diacrylates. In addition abundant feedstocks, method is efficient air-tolerant, uses common organic bases as catalysts, yields with high molecular weights under mild conditions. Such polymers, structurally like polyethylene low-density in-chain polar groups, manifest impressive toughness ductility comparable high-density polyethylene. ester group acts breaking point, enabling these undergo chemical recycling through two loops. structures properties also have an immeasurably expanded range owing versatility our method. readily available raw materials, facile synthesis, performance make promising prospects sustainable materials practice.

Language: Английский

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Hydrogenative alkene perdeuteration aided by a transient cooperative ligand

Nature Chemistry, Journal Year: 2023, Volume and Issue: 15(10), P. 1384 - 1390

Published: Sept. 4, 2023

Language: Английский

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Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(11)

Published: March 7, 2024

Water is known to play an important role in collagen self-assembly, but it still largely unclear how water–collagen interactions influence the assembly process and determine fibril network properties. Here, we use H 2 O/D O isotope effect on hydrogen-bond strength water investigate of hydration self-assembly. We dissolve D compare growth kinetics structure assemblies formed these isotopomers. Surprisingly, occurs ten times faster than O, self-assembles into much thinner fibrils, that form a more inhomogeneous softer network, with fourfold reduction elastic modulus when compared O. Combining spectroscopic measurements atomistic simulations, show less hydrated This partial dehydration lowers enthalpic penalty for removal reorganization at collagen–water interface, increasing self-assembly rate number nucleation centers, leading fibrils network. Coarse-grained simulations acceleration initial can be reproduced by enhancement electrostatic interactions. These results acts as mediator between monomers, modulating their so optimize and, thus, final believe isotopically proteins valuable method protein structural dynamics

Language: Английский

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Microenvironment regulation breaks the Faradaic efficiency-current density trade-off for electrocatalytic deuteration using D2O

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 19, 2024

Abstract The high Faradaic efficiency (FE) of the electrocatalytic deuteration organics with D 2 O at a large current density is significant for deuterated electrosynthesis. However, FE and are two ends seesaw because severe evolution side reaction nearly industrial densities. Herein, we report combined scenario nanotip-enhanced electric field surfactant-modified interface microenvironment to enable arylacetonitrile in an 80% −100 mA cm −2 . increased concentration low activation energy due along tips accelerated transfer suppressed by surfactant-created deuterophobic contribute breaking trade-off between density. Furthermore, application our strategy other reactions improved efficiencies rationalizes design concept.

Language: Английский

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Infrared plastic optics and photonic devices using chalcogenide hybrid inorganic/organic polymers via inverse vulcanization of elemental sulfur

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 156, P. 101865 - 101865

Published: Aug. 8, 2024

Language: Английский

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Catalytic asymmetric deuterosilylation of exocyclic olefins with mannose-derived thiols and deuterium oxide

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(5), P. 1182 - 1190

Published: Jan. 1, 2023

Metal-free, photoinduced asymmetric deuterosilylation of exocyclic olefins has been achieved using a mannose-derived thiol catalyst.

Language: Английский

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Atom-economical synthesis of 1,2-bis(phosphine oxide)ethanes from calcium carbide with straightforward access to deuterium- and¹³C-labeled bidentate phosphorus ligands and metal complexes

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(4), P. 1022 - 1033

Published: Jan. 1, 2023

Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed incorporate 2 H 13 C labels using easily available reagents.

Language: Английский

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