iScience,
Journal Year:
2024,
Volume and Issue:
27(9), P. 110692 - 110692
Published: Aug. 12, 2024
Polyester
biomaterials
play
a
crucial
in
vascular
surgery,
but
suffer
from
unspecific
protein
adsorption,
thrombogenicity,
and
inadequate
endothelial
cell
response,
which
limit
their
success.
To
address
these
issues,
we
investigated
the
functionalization
of
polyester
with
antithrombogenic
polysaccharide
coatings.
A
two-step
water-based
method
was
used
to
coat
cationized
polycaprolactone
different
sulfated
polysaccharides
(SPS),
resulted
long-term
stability,
tunable
morphology,
roughness,
film
thickness,
chemical
compositions,
zeta
potential,
water
content.
The
coatings
significantly
increased
anticoagulant
activity
reduced
thrombogenicity
polycaprolactone,
particularly
highly
heparin
cellulose
sulfate.
Less
SPS,
such
as
chondroitin
sulfate,
fucoidan,
carrageenan,
despite
showing
activity,
also
exhibited
lower
fibrinogen
adsorption.
adhesion
viability
human
primary
cells
cultured
on
modified
correlated
type
sulfate
content
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 12, 2023
Clinical
use
of
intraoperative
auto-transfusion
requires
the
removal
platelets
and
plasma
proteins
due
to
pump-based
suction
water-soluble
anticoagulant
administration,
which
causes
dilutional
coagulopathy.
Herein,
we
develop
a
carboxylated
sulfonated
heparin-mimetic
polymer-modified
sponge
with
spontaneous
blood
adsorption
instantaneous
anticoagulation.
We
find
that
intrinsic
coagulation
factors,
especially
XI,
are
inactivated
by
surface,
while
inactivation
thrombin
in
sponge-treated
effectively
inhibits
common
pathway.
show
whole
trauma-induced
hemorrhage,
benefiting
from
multiple
inhibitory
effects
on
enzymes
calcium
depletion.
demonstrate
transfusion
collected
favors
faster
recovery
hemostasis
compared
traditional
heparinized
rabbit
model.
Our
work
not
only
develops
safe
convenient
approach
for
auto-transfusion,
but
also
provides
mechanism
action
self-anticoagulant
surfaces.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 3, 2024
With
the
rapid
advancement
of
implantable
electronic
medical
devices,
supercapacitors
have
emerged
as
popular
energy
storage
devices.
However,
inevitably
come
into
direct
contact
with
blood
when
implanted,
potentially
causing
adverse
clinical
reactions
such
coagulation
and
thrombosis,
impairing
performance
implanted
posing
a
serious
threat
to
human
health.
Therefore,
this
work
aims
design
an
anticoagulant
supercapacitor
by
heparin
doped
poly(3,
4-ethylenedioxythiophene)
(PEDOT)
for
possible
applications
in
bioelectronics.
Heparin
(Hep),
as-known
macromolecule
acts
counterion
PEDOT
doping
enhance
its
conductivity,
bioelectrode
material
PEDOT:
Hep
activity
is
synthesized
via
chemical
oxidation
polymerization.
Concurrently,
constructed
through
in-situ
polymerization,
where
bacterial
cellulose
electrode
electrolyte
layer,
respectively.
Owing
incorporation
heparin,
exhibits
high
hemocompatibility
hemolysis
rate
<5
%,
good
time
63.4
s,
reasonable
cycle
stability
capacitance
retention
76.24
%
after
20,
000
cycles,
supplies
power
heart
sensors
female
mice.
This
provides
platform
electronics
achieve
vivo.
Implantable
are
promising
use
supply
devices
within
body,
but
their
utility
hindered
thrombosis.
Here,
authors
report
that
properties
cycling
stability.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 21, 2024
Poly(3,
4-ethylenedioxythiophene)
(PEDOT)
as
a
new
generation
of
intelligent
conductive
polymers,
is
attracting
much
attention
in
the
field
tissue
engineering.
However,
its
water
dispersibility,
conductivity,
and
biocompatibility
are
incompatible,
which
limit
further
development.
In
this
work,
biocompatible
electrode
material
PEDOT
doped
with
sodium
sulfonated
alginate
(SS)
contains
two
functional
groups
sulfonic
acid
carboxylic
per
repeat
unit
macromolecule.
The
dual-site
doping
strategy
simultaneously
boosts
anticoagulant
electrochemical
performances,
for
example,
good
hydrophilicity
(water
contact
angle
59.40°),
well
dispersibility
(dispersion
solution
unstratified
30
days),
high
conductivity
(4.45
S
m
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
11(1), P. 634 - 648
Published: Jan. 3, 2025
Valvular
heart
disease
(VHD)
poses
a
significant
threat
to
human
health,
and
the
transcatheter
valve
replacement
(THVR)
is
best
treatment
for
severe
VHD.
Currently,
glutaraldehyde
cross-linked
commercial
bioprosthetic
valves
(BHVs)
remain
first
choice
THVR.
However,
cross-linking
by
exhibits
several
drawbacks,
including
calcification,
inflammatory
reactions,
difficult
endothelialization,
which
limits
longevity
applicability
of
BHVs.
In
this
study,
λ-carrageenan
with
anticoagulant
function
was
modified
carboxymethylation
into
carboxymethyl
(CM-λC);
subsequently,
CM-λC
used
as
agent
stabilize
decellularized
bovine
pericardial
tissue
through
amide
bonds
formed
1-(3-(Dimethylamino)propyl)-3-ethylcarbodiimide/N-Hydroxysuccinimide
(EDC/NHS)-catalyzed
reaction
between
amino
functional
groups
within
pericardium
carboxyl
group
located
on
CM-λC.
Lastly,
inclusion
complex
(CD/Rutin)
(formed
encapsulating
rutin
molecule
hydrophobic
cavity
mono-(6-ethylenediamine-6-deoxy)-β-cyclodextrin)
immobilized
onto
above
BHVs
materials
(λCar-BP)
amidation
reaction.
The
treated
sample
exhibited
mechanical
properties
collagen
stability
similar
those
GA-BP,
except
improved
flexibility.
Because
presence
sulfonic
acid
absence
aldehyde
well
Rutin
release
from
CD/Rutin
BHVs,
hemocompatibility,
anti-inflammatory,
HUVEC-cytocompatibility,
anticalcification
properties,
CM-λC-fixed
BP
significantly
better
than
that
GA-BP.
summary,
nonaldehyde-based
natural
polysaccharide
strategy
utilizing
combination
provides
novel
solution
obtain
durable
stable
anticoagulant,
anticalcification,
anti-inflammatory
has
wide
range
potential
applications
in
improving
various
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Bioactive
surfaces
play
a
pivotal
role
in
biomedical
applications
by
enabling
precise
biological
interactions
through
immobilized
functional
molecules.
However,
their
performance
is
often
hindered
nonspecific
protein
adsorption
and
cell
adhesion.
Antifouling
polymer
coatings
have
emerged
as
an
effective
solution,
creating
hydration
barriers
to
preserve
functionality
reduce
biofouling.
This
review
provides
overview
of
the
recent
advances
development
antifouling
for
bioactive
surfaces,
with
particular
focus
on
nonionic
polymers,
such
polyethylene
glycol
(PEG),
zwitterionic
polymers
like
poly(2-methacryloyloxyethyl
phosphorylcholine)
(PMPC).
Among
them,
unique
charge-balanced
structures,
exhibit
exceptional
hydration,
resistance,
stability,
making
them
particularly
promising
applications.
In
addition,
key
these
including
use
anticoagulant
materials,
antibacterial
coatings,
biosensor
interfaces,
are
also
discussed.
The
discussion
concludes
address
field's
challenges
future
directions,
highlighting
need
innovative
materials
that
balance
properties,
biocompatibility,
long-term
stability
both
clinical
industrial
use.
aims
latest
advancements
provide
insights
into
optimizing
multifunctional
meet
evolving
dynamic
demands
field.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Implantable
cardiovascular
devices
have
revolutionized
the
treatment
of
diseases,
yet
their
long-term
functionality
without
causing
thrombosis
is
a
persistent
challenge.
Although
surface
modification
anticoagulant
coating
has
greatly
improved
biocompatibility
devices,
its
stability
in
complex
physiological
environments
still
remains
questionable.
Herein,
three
hydrogel
coatings,
poly(2-methacryloyloxyethyl
phosphorylcholine)
(PMPC),
poly(sodium
2-acryloyl-2-methylpropanesulfonate)
(PAMPS),
and
poly(4-styrenesulfonate
sodium)
(PSS),
studied.
The
fabrication
these
coatings
onto
device
surfaces
validated
by
using
X-ray
photoelectron
spectroscopy
(XPS)
attenuated
total
reflectance
Fourier
transform
infrared
(ATR-FTIR)
spectroscopy.
In
vitro
anticoagulation
assays
confirm
coatings'
significant
effects.
Among
all
PSS
demonstrated
superior
chemical
mechanical
comprehensive
tests,
showing
great
potential
for
improving
performance
implantable
devices.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
With
the
rapid
development
of
implantable
electronic
medical
devices,
supercapacitors
have
gained
significant
attention
as
energy
storage
devices
due
to
their
inherent
advantages.
However,
these
inevitably
direct
contact
with
blood
and
trigger
coagulation
or
thrombus
formation
when
implanted
in
body.
In
severe
cases,
negative
effects
compromise
functionality
system
even
jeopardize
human
health.
Herein,
a
biocompatible
electrode
material
high
anticoagulant
activity
is
designed
by
doping
polyaniline
macromolecule
heparin
under
neutral
conditions,
which
macromolecules
dopants
conditions
not
only
avoids
toxicity
acids
biological
tissues
de‐doping
caused
small
molecules,
but
also
imparts
properties
material.
Based
on
situ
polymerization
approach,
an
all‐in‐one
anticoagulation
supercapacitor
employed
manufacture
exhibits
good
electrochemical
performance
(energy
density
18.89
µWh
cm
−2
power
197.8
µW
),
cycling
stability
(capacitance
retention
70.23%
after
2,
000
cycles),
(APTT
15.47
s,
PT
16.57
TT
49.47
FIB
1.12
g
L
−1
tissue
compatibility.
The
strategy
provides
valuable
reference
for
supply
bioelectronics.
