Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123026 - 123026
Published: Dec. 15, 2024
Language: Английский
MedComm, Journal Year: 2025, Volume and Issue: 6(5)
Published: April 28, 2025
ABSTRACT Molecular hydrogen (H 2 ), recognized as the smallest gas molecule, is capable of permeating cellular membranes and diffusing throughout body. Due to its high bioavailability, H considered a therapeutic for treatment various diseases. The efficacy contingent upon factors such administration method, duration contact with diseased tissue, concentration at targeted sites. can be administered exogenously also produced endogenously within intestinal tract. A comprehensive understanding delivery mechanisms modes action crucial advancing medicine. This review highlights H₂’s action, summarizes methods, explores advancements in treating diseases (e.g., inflammatory bowel disease, ischemia–reperfusion, colorectal cancer). Additionally, applications managing other are discussed. Finally, challenges associated clinical application potential solutions explored. We propose that current faced by effectively addressed through use nanoplatforms; furthermore, interactions between gut microbiota may provide insights into Future research should explore synergistic effects conjunction conventional therapies develop personalized plans achieve precision
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: May 8, 2025
Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well a huge social burden. Among these caused by inner ear lesions accounts for large proportion. Therefore, treatment the important. Inner drug delivery systems, which can reduce side effects systemic administration delivering drugs directly ear, are important in sensorineural loss. Here, development systems focused, including complex physiological structure that they face, types delivered, routes administration, forms carrier platforms. Recent studies this process presented it concluded summary outlook on problems faced possible solutions.
Language: Английский
Citations
0
Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 1, 2024
The intricate physiological structure of the inner ear presents challenges for traditional medication treatment strategies, including systemic adverse responses, trouble penetrating blood–labyrinth barrier, and low local cochlear concentration, resulting in poor therapeutic outcomes. An intriguing tactic that is extensively developed over decades utilizing drug delivery systems to transport molecules ear. Herein, associated with are discussed, cutting‐edge achievements emphasized, nano‐, micro‐, macrocarriers, finally opportunities leverage advanced technologies improve existing strategies highlighted.
Language: Английский
Citations
3
Small, Journal Year: 2024, Volume and Issue: 20(44)
Published: July 17, 2024
Multidrug combination therapy in the inner ear faces diverse challenges due to distinct physicochemical properties of drugs and difficulties overcoming oto-biologic barrier. Although nanomedicine platforms offer potential solutions multidrug delivery, access remains limited. Micro/nanomachines, capable delivering cargo actively, are promising tools for bio-barriers. Herein, a novel microrobot-based strategy penetrate round window membrane (RWM) is presented on-demand manner delivered. The tube-type microrobot (TTMR) constructed using template-assisted layer-by-layer (LbL) assembly chitosan/ferroferric oxide/silicon dioxide (CS/Fe
Language: Английский
Citations
3
Translational Neuroscience, Journal Year: 2023, Volume and Issue: 14(1)
Published: Jan. 1, 2023
Neuroinflammation, a complex process involving the activation of microglia, astrocytes, and other immune cells in brain, plays role neurodegeneration psychiatric disorders. Current therapeutic strategies for neuroinflammation are limited, necessitating development improved approaches. Nanopharmacology offers unprecedented opportunities to access treat neuroinflammatory disorders at brain level. Nanoscaffolds can target specific or tissues protect drugs from degradation elimination, making them ideal candidates treating neurodegenerative diseases. Recent advancements nanoparticle have enabled targeting reducing protecting neurons injury. Nanoparticles also been developed. Clinical trials progress evaluate safety efficacy nano neuroinflammatory, neurodegenerative, The successful these nanodrugs holds immense promise devastating increasingly prevalent conditions. On hand, several limitations unanswered questions remain. First, long-term effects nanoparticles on need be thoroughly investigated ensure their safety. Second, optimizing delivery regions remains challenge. Understanding interplay between brain's system is crucial developing effective nanotherapies. Despite limitations, nanopharmacology presents transformative approach Future research should address aforementioned further elucidate mechanisms nanoparticle-mediated therapy. safe revolutionize treatment disorders, alleviating suffering millions.
Language: Английский
Citations
4
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113855 - 113855
Published: March 16, 2024
Language: Английский
Citations
1
Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25
Published: July 23, 2024
To investigate eutectic liquid-based emulsion-like dispersions for intratympanic injections to augment cinnarizine permeability across round window membrane in a healthy rabbit inner ear model.
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4006 - 4023
Published: Jan. 1, 2024
Biomaterials as a new option has revolutionized the treatment of sensorineural hearing loss.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106387 - 106387
Published: Nov. 7, 2024
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123026 - 123026
Published: Dec. 15, 2024
Language: Английский
Citations
0