COVID-19 vaccines: The status and perspectives in delivery points of view

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 170, P. 1 - 25

Published: Dec. 24, 2020

Language: Английский

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A materials-science perspective on tackling COVID-19

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(11), P. 847 - 860

Published: Oct. 14, 2020

The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research treatment development. In this Review, we discuss previous efforts developing imaging systems microfluidic devices in-depth real-time investigation viral structures transmission, as well material platforms detection viruses delivery drugs vaccines. We highlight contribution to manufacturing personal protective equipment design simple, accurate low-cost virus-detection devices. then investigate future possibilities development, examining role antiviral-drug design, including synthetic organoids organs-on-a-chip, drug vaccination, production medical equipment. Materials-science-based not only contribute but can also provide understanding, protection, diseases. Materials provides protection against infections, diagnosis, prevention This Review discusses present directions materials-science research, with a focus on COVID-19.

Language: Английский

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Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(44), P. 27141 - 27147

Published: Oct. 6, 2020

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the urgent need to rapidly develop therapeutic strategies for such emerging viruses without effective vaccines or drugs. Here, we report a decoy nanoparticle against through powerful two-step neutralization approach: virus in first step followed cytokine second step. nanodecoy, made fusing cellular membrane nanovesicles derived from human monocytes and genetically engineered cells stably expressing angiotensin converting enzyme II (ACE2) receptors, possesses an antigenic exterior same as source cells. By competing with host binding, these nanodecoys effectively protect infection of pseudoviruses authentic SARS-CoV-2. Moreover, relying on abundant receptors surface, efficiently bind neutralize inflammatory cytokines including interleukin 6 (IL-6) granulocyte-macrophage colony-stimulating factor (GM-CSF), significantly suppress immune disorder lung injury pneumonia mouse model. Our work presents simple, safe, robust antiviral nanotechnology ongoing future potential epidemics.

Language: Английский

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Electrochemical SARS-CoV-2 Sensing at Point-of-Care and Artificial Intelligence for Intelligent COVID-19 Management

ACS Applied Bio Materials, Journal Year: 2020, Volume and Issue: 3(11), P. 7306 - 7325

Published: Oct. 27, 2020

To manage the COVID-19 pandemic, development of rapid, selective, sensitive diagnostic systems for early stage β-coronavirus severe acute respiratory syndrome (SARS-CoV-2) virus protein detection is emerging as a necessary response to generate bioinformatics needed efficient smart diagnostics, optimization therapy, and investigation therapies higher efficacy. The urgent need such recommended by experts in order achieve mass targeted SARS-CoV-2 required pandemic through understanding infection progression timely therapy decisions. these tasks, there scope developing sensors rapidly selectively detect at picomolar level. infection, due human-to-human transmission, demands diagnostics point-of-care (POC) without experienced labor sophisticated laboratories. Keeping above-mentioned considerations, we propose explore compartmentalization approach designing nanoenabled miniaturized electrochemical biosensors site epidemic best way pandemic. Such based on POC sensing technology can be interfaced with Internet things artificial intelligence (AI) techniques (such machine learning deep diagnostics) investigating useful informatics via data storage, sharing, analytics. management related challenges aspects under consideration, our work this review presents collective involving biosensing supported AI diagnosis, correlation viral load pathogenesis, progression, optimization, diseases personalized manner.

Language: Английский

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Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Language: Английский

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Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 6(7), P. 791 - 805

Published: July 4, 2022

Language: Английский

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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

Cell, Journal Year: 2021, Volume and Issue: 184(10), P. 2605 - 2617.e18

Published: March 18, 2021

Language: Английский

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Insights from nanotechnology in COVID-19 treatment

Nano Today, Journal Year: 2020, Volume and Issue: 36, P. 101019 - 101019

Published: Nov. 5, 2020

Language: Английский

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Drug Targeting via Platelet Membrane–Coated Nanoparticles

Small Structures, Journal Year: 2020, Volume and Issue: 1(1)

Published: Sept. 9, 2020

Platelets possess distinct surface moieties responsible for modulating their adhesion to various disease-relevant substrates involving vascular damage, immune evasion, and pathogen interactions. Such broad biointerfacing capabilities of platelets have inspired the development platelet-mimicking drug carriers that preferentially target payloads disease sites enhanced therapeutic efficacy. Among these carriers, platelet membrane-coated nanoparticles (denoted 'PNPs') made by cloaking synthetic with plasma membrane emerged recently. Their 'top-down' design combines functionalities natural engineering flexibility nanomaterials, which together create synergy effective delivery novel therapeutics. Herein, we review recent progress PNPs different structures targeted delivery, focusing on three areas, including targeting injured blood vessels treat diseases, cancer cells treatment detection, drug-resistant bacteria infectious diseases. Overall, current studies established as versatile nanotherapeutics strong potentials improve

Language: Английский

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Cell primitive-based biomimetic functional materials for enhanced cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 945 - 985

Published: Nov. 23, 2020

Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.

Language: Английский

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