Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Magnetic Microswarm Composed of Porous Nanocatalysts for Targeted Elimination of Biofilm Occlusion

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 5056 - 5067

Published: Feb. 26, 2021

Biofilm is difficult to thoroughly cure with conventional antibiotics due the high mechanical stability and antimicrobial barrier resulting from extracellular polymeric substances. Encouraged by great potential of magnetic micro-/nanorobots in various fields their enhanced action swarm form, we designed a microswarm consisting porous Fe3O4 mesoparticles (p-Fe3O4 MPs) explored its application biofilm disruption. Here, p-Fe3O4 MPs swarm) was generated actuated simple rotating field, which exhibited capability remote actuation, cargo capacity, strong localized convections. Notably, could eliminate biofilms efficiency synergistic effects chemical physical processes: (i) generating bactericidal free radicals (•OH) for killing bacteria cells degrading MPs; (ii) physically disrupting promoting •OH penetration deep into motion. As demonstration targeted treatment, be clear along geometrical route on 2D surface sweep away clogs 3D U-shaped tube. This platform holds treating occlusions particularly inside tiny tortuous cavities medical industrial settings.

Language: Английский

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Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Nano Today, Journal Year: 2022, Volume and Issue: 46, P. 101602 - 101602

Published: Sept. 1, 2022

Language: Английский

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Organic Photo-antimicrobials: Principles, Molecule Design, and Applications

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(43), P. 17891 - 17909

Published: Oct. 22, 2021

The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for current serious antibiotic resistance. During PT treatment, reactive oxygen species or heat produced PAMs would react with cell membrane, consequently leaking cytoplasm components and effectively eradicating different like bacteria, fungi, viruses, even parasites. This Perspective will concentrate on development organic (OPAMs) their application as practical therapeutic agents into therapy local infections, wound dressings, removal biofilms from medical devices. We also discuss how to design highly efficient OPAMs modifying chemical structure conjugating a targeting component. Moreover, this provides discussion general challenges direction what further needs be done. It is hoped that through overview, can prosper more widely used microbial infections future, especially at time when global COVID-19 epidemic getting serious.

Language: Английский

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Photodynamic and photothermal co-driven CO-enhanced multi-mode synergistic antibacterial nanoplatform to effectively fight against biofilm infections

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 426, P. 131919 - 131919

Published: Aug. 21, 2021

Language: Английский

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Infection Micromilieu‐Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(7)

Published: Nov. 5, 2021

Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous regeneration is devised developed. In this “intelligent” system, PLGA membranes gradually degrade to lactate, LOx consumes yield abundant hydrogen peroxide (H O ) in a microenvironment‐responsive manner. addition, MX/AS bio‐HJs not only exert benign photothermal effects generate reactive oxygen species upon NIR light, but also catalyze produced H overwhelming hydroxyl radicals (·OH) through Fenton‐like reactions, which all result rapid synergistic sterilization. Furthermore, vivo assays demonstrate that reshape stalled wound into regenerative by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition beds, promoting angiogenesis. As envisaged, proposed tactic opens up promising opportunity arming with IME‐responsive activity remedy bacteria‐invaded full‐thickness wounds.

Language: Английский

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Heat-Mediated Optical Manipulation

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(3), P. 3122 - 3179

Published: Nov. 19, 2021

Progress in optical manipulation has stimulated remarkable advances a wide range of fields, including materials science, robotics, medical engineering, and nanotechnology. This Review focuses on an emerging class techniques, termed heat-mediated manipulation. In comparison to conventional tweezers that rely tightly focused laser beam trap objects, techniques exploit tailorable optothermo-matter interactions rich mass transport dynamics enable versatile control matter various compositions, shapes, sizes. addition tweezing, more distinct modes, optothermal pulling, nudging, rotating, swimming, oscillating, walking, have been demonstrated enhance the functionalities using simple low-power optics. We start with introduction basic physics involved manipulation, highlighting major working mechanisms underpinning variety techniques. Next, we categorize based different discuss capabilities, applications for each technique. conclude this our outlook current challenges future opportunities rapidly evolving field

Language: Английский

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Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Journal Year: 2022, Volume and Issue: 19(6)

Published: Dec. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Language: Английский

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Controlled propulsion of micro/nanomotors: operational mechanisms, motion manipulation and potential biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(24), P. 10083 - 10119

Published: Jan. 1, 2022

Micro/nanomotors with advanced motion manipulation show great promise in biomedical fields. This review article critically summarizes the working principles, strategies, applications, and future prospects of micro/nanomotors.

Language: Английский

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Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment

Advanced Science, Journal Year: 2022, Volume and Issue: 9(29)

Published: Aug. 28, 2022

Due to the continuous rise in biofilm-related infections, biofilms seriously threaten human health. The formation of makes conventional antibiotics ineffective and dampens immune clearance. Therefore, it is important understand mechanisms biofilm develop novel strategies treat more effectively. This review article begins with an introduction various clinical scenarios their corresponding therapy. Established models used research are then summarized. potential targets which may assist development new for combating further discussed. technologies developed recently prevention treatment including antimicrobial surface coatings, physical removal biofilms, molecules, delivery agents subsequently presented. Finally, directions future studies pointed out.

Language: Английский

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