Emergent Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 4(2)
Published: Oct. 17, 2023
Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.
Language: Английский
Citations
55
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)
Published: May 15, 2023
Abstract The application of medical implants has greatly improved the survival rate and life quality patients. Nevertheless, in recent years, there are increasing cases implant dysfunction or failure because bacterial infections. Despite significant improvements biomedicine, still serious challenges treatment implant‐related With formation biofilms development resistance, these limitations lead to a low efficacy conventional antibiotics. To address challenges, it is urgent exploit innovative strategies for Based on ideas, environment‐responsive therapeutic platforms with high selectivity, drug minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, antibacterial activity therapeutics can be activated demand exhibit remarkable effects. Exogenous stimuli include photo, magnetism, microwave, ultrasound. Endogenous mainly pathological characteristics infections such as acidic pH, anomalous temperature, abnormal enzymatic activities. In this review, progress spatiotemporally controlled release/activation systematically summarized. Afterward, opportunities emerging highlighted. Finally, hoped that review will offer novel ideas techniques combat
Language: Английский
Citations
42
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761
Published: Jan. 1, 2023
The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.
Language: Английский
Citations
42
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19
Published: Feb. 7, 2024
Language: Английский
Citations
36
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(4), P. 133 - 133
Published: March 29, 2024
Biofilms, which consist of microorganisms enclosed in an extracellular polymeric material (EPS), hold immense importance the fields environmental research, industry, and medicine. They play a significant role ecosystem dynamics stability, but they also pose issues such as biofouling, corrosion, pollution. Biofilms medical environments are linked to persistent infections elevated healthcare expenses. The EPS matrix plays crucial maintaining structural integrity antibiotic resistance these structures. research primarily investigates facilitating horizontal gene transfer among biofilm communities, with particular emphasis on its impact this process. process is recognized pivotal mechanism emergence resistance, underscoring function biofilms. analysis highlights financial constraints caused by biofilms several industries. Biofilm-associated sector result escalated treatment expenses extended hospitalization periods. In industrial context, have increasing maintenance product contamination, emphasizing need for efficient management solutions. This review presents most recent progress utilization sophisticated imaging tools molecular methodologies. addition conventional techniques, explores tools, DNA RNA sequencing, conjunction proteomics. These approaches essential assessing genetic metabolic mechanisms that regulate development resistance. underscores significance employing interdisciplinary methodology study By incorporating range approaches, analysis, comprehensive understanding may be achieved. approach opens up possibilities developing novel solutions address negative impacts health, environment.
Language: Английский
Citations
16
Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 199, P. 107277 - 107277
Published: Jan. 5, 2025
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)
Published: Oct. 20, 2023
Abstract Chronic wounds caused by bacterial infections are a major challenge in medical fields. The hypoxia condition extremely induces reactive oxygen species (ROS) generation and upregulates the expression of hypoxia‐inducible factor, both which can increase pro‐inflammatory M1 subtype macrophages production while reducing anti‐inflammatory M2 macrophages. Besides, bacteria‐formed biofilms hinder penetration therapeutic agents. Encouraged natural motors automatically executing tasks, hypothesized that supplying sufficient (O 2 ) would simultaneously drive agent movement, rescue hypoxic microenvironment, disrupt vicious cycle inflammation. Here, small organic molecule‐based nanoparticles (2TT‐mC6B@Cu 5.4 O NPs) possess high photothermal conversion efficiency enzymatic activities developed, including superoxide dismutase‐, catalase‐, glutathione peroxidase‐like activity. 2TT‐mC6B@Cu NPs exhibit superior ROS‐scavenging abilities synergistically relieve inflammation, alleviate conditions, promote their deep chronic wound tissues. Transcriptome analysis further demonstrates 2TT‐[email protected] inhibit biological inside bacteria. Furthermore, vivo experiments prove NPs‐based hyperthermia effectively eliminate bacteria to healing.
Language: Английский
Citations
37
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1489 - 1489
Published: June 3, 2023
Antibiotic usage and resistance are major health concerns. occurs when bacteria evolve to resist the effects of antibiotics, making it impossible treat infections. The overuse misuse antibiotics main contributing factors, while environmental stress (such as heavy metals accumulation), unhygienic conditions, illiteracy, unawareness also contribute antibiotic resistance. slow costly development new has lagged behind emergence antibiotic-resistant bacteria, leads negative consequences. current study used different literature resources generate an opinion find a possible solution barriers. Different scientific approaches have been reported overcome most useful approach among these is nanotechnology. Nanoparticles can be engineered disrupt bacterial cell walls or membranes, effectively eliminating resistant strains. Additionally, nanoscale devices enable real-time monitoring populations, allowing for early detection emergence. Nanotechnology, along with evolutionary theory offers promising avenues in combating Evolutionary helps us understand mechanisms by which develop resistance, anticipate counteract their adaptive strategies. By studying selective pressures that drive we therefore design more effective interventions traps. synergy between nanotechnology presents powerful combat offering treatments preservation our arsenal.
Language: Английский
Citations
33
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
The advent of drug-resistant pathogens results in the occurrence stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating body's immune system to eliminate pathogenic bacteria has confirmed promising therapeutic strategies controlling infections. Subsequent studies found antimicrobial its own benefits and limitations, such as avoiding recurrence infection autoimmunity-induced side effects. Current indicate various antibacterial inducing regulation can achieve superior efficacy compared monotherapy alone. Therefore, summarizing recent advances nanomedicine immunomodulatory functions for combating is necessary. Herein, we briefly introduce crisis caused opportunity immunotherapy. Then, immune-involved multimodal therapy treatment infectious diseases was systematically summarized. Finally, prospects challenges combinational are discussed.
Language: Английский
Citations
31
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 170, P. 389 - 400
Published: Aug. 23, 2023
Language: Английский
Citations
27