Nano Research, Journal Year: 2022, Volume and Issue: 16(1), P. 715 - 734
Published: Sept. 16, 2022
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 180, P. 114079 - 114079
Published: Dec. 10, 2021
Language: Английский
Citations
330
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616
Published: April 16, 2024
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.
Language: Английский
Citations
217
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215152 - 215152
Published: April 3, 2023
Language: Английский
Citations
118
Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(6), P. 941 - 960
Published: May 10, 2023
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large variety of therapeutics. Currently in the spotlight important constituents COVID-19 mRNA vaccines, LNPs play significant role protecting and transporting cells. As one their key constituents, polyethylene glycol (PEG)–lipid conjugates are defining LNP physicochemical characteristics biological activity. PEGylation has proven particularly conferring longer systemic circulation LNPs, thus greatly improving pharmacokinetics efficiency. Along with revealing benefits PEG conjugates, studies revealed unexpected immune reactions against PEGylated nanocarriers such accelerated blood clearance (ABC), involving production anti-PEG antibodies at initial injection, which initiates upon subsequent injections, well hypersensitivity reaction referred complement activation-related pseudoallergy (CARPA). Further, data accumulated indicating consistent yet sometimes controversial correlations between various structural parameters PEG–lipids, properties magnitude observed adverse effects. Detailed knowledge comprehension foremost importance efforts diminish eliminate undesirable improve safety efficiency medicines. Here, we present an overview based on analysis from CAS Content Collection regarding immunogenicity overall concerns. A comprehensive summary compiled outlining how PEG–lipids affect responses activities regards drug delivery. This Review is intended serve helpful resource understanding current field, effort further solve remaining challenges achieve full potential.
Language: Английский
Citations
100
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(11), P. 4287 - 4336
Published: Jan. 1, 2022
Advanced treatments based on immune system manipulation, gene transcription and regulation, specific organ cell targeting, and/or photon energy conversion have emerged as promising therapeutic strategies against a range of challenging diseases. Naturally derived macromolecules (e.g., proteins, lipids, polysaccharides, polyphenols) increasingly found use fundamental building blocks for nanostructured particles their advantageous properties, including biocompatibility, biodegradability, inherent bioactivity, diverse chemical properties make them suitable advanced applications. This review provides timely comprehensive summary the broad natural in rapidly developing field therapeutics with insights to particles. We focus an up-to-date overview assembly using summarize key scientific preclinical milestones therapies, adoptive therapy, immunotherapy, active targeted drug delivery, photoacoustic therapy imaging, photothermal combinational therapy. A cross-comparison advantages disadvantages different are highlighted elucidate design principles such bio-derived nanoparticles toward improving performance adoption. Current challenges future research directions also discussed, which will accelerate our understanding designing, engineering, applying therapies.
Language: Английский
Citations
97
Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(40), P. 18419 - 18428
Published: Sept. 27, 2022
Surface modification with poly(ethylene glycol) (PEGylation) is an effective strategy to improve the colloidal stability of nanoparticles (NPs) and often used minimize cellular uptake clearance NPs by immune system. However, PEGylation can also trigger accelerated blood (ABC) phenomenon, which known reduce circulation time PEGylated NPs. Herein, we report engineering stealth PEG that avoid ABC phenomenon and, when modified hyaluronic acid (HA), show specific cancer cell targeting drug delivery. cross-linked disulfide bonds are prepared using zeolitic imidazolate framework-8 as templates. The reported templating enables simultaneous removal template formation under mild conditions (pH 5.5 buffer). Compared liposomes, secretion anti-PEG antibodies presence IgM IgG did not significantly accelerate NPs, indicating inhibition effect for Functionalization HA affords retain their properties against macrophages, target CD44-expressed cells loaded anticancer doxorubicin, effectively inhibit tumor growth. innovation this study lies in circumvent be functionalized improved targeted delivery drugs.
Language: Английский
Citations
85
Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10
Published: June 7, 2022
Poly (ethylene glycol) (PEG) is a widely used polymer in variety of consumer products and medicine. PEGylation refers to the conjugation PEG drugs or nanoparticles increase circulation time reduce unwanted host responses. viewed as being well-tolerated, but previous studies have identified anti-PEG antibodies so-called pseudoallergic reactions certain individuals. The increased use contrast agents drug delivery, along with introduction mRNA vaccines encapsulated PEGylated lipid has brought this issue fore. Thus, while these proven be remarkably effective, rare cases anaphylaxis been reported, tentatively ascribed carriers, which may trigger complement activation susceptible Here, we provide general overview for pharmaceutical applications, discuss cascade that might caused by nanomedicines better understanding immunological adverse reactions.
Language: Английский
Citations
77
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 778 - 778
Published: April 2, 2022
Liposomes are highly advantageous platforms for drug delivery. To improve the colloidal stability and avoid rapid uptake by mononuclear phagocytic system of conventional liposomes while controlling release encapsulated agents, modification with well-designed polymers to modulate physiological, particularly interfacial properties carriers, has been intensively investigated. Briefly, incorporated into mainly using "grafting" or "coating", defined according configuration at surface. Polymer-modified preserve advantages as drug-delivery carriers possess specific functionality from polymers, such long circulation, precise targeting, stimulus-responsiveness, thereby resulting in improved pharmacokinetics, biodistribution, toxicity, therapeutic efficacy. In this review, we summarize progress polymer-modified delivery, focusing on change physiological factors influencing overall
Language: Английский
Citations
75
Small, Journal Year: 2023, Volume and Issue: 19(28)
Published: April 3, 2023
Abstract Although a wide variety of nanoparticles (NPs) have been engineered for use as disease markers or drug delivery agents, the number nanomedicines in clinical has hitherto remained small. A key obstacle nanomedicine development is lack deep mechanistic understanding NP interactions bio‐environment. Here, focus on biomolecular adsorption layer (protein corona), which quickly enshrouds pristine exposed to biofluid and modifies way interacts with After brief introduction NPs nanomedicine, proteins, their mutual interactions, research aimed at addressing fundamental properties protein corona, specifically its mono‐/multilayer structure, reversibility irreversibility, time dependence, well role agglomeration, critically reviewed. It becomes quite evident that knowledge corona still fragmented, conflicting results issues call further studies. The article concludes discussion future directions should be taken advance around NPs. This will provide developers predictive power account these design efficacious nanomedicines.
Language: Английский
Citations
43
Chem, Journal Year: 2023, Volume and Issue: 10(2), P. 504 - 543
Published: Oct. 16, 2023
Metal-organic frameworks (MOFs) have emerged as a potential platform for biomedical applications due to their highly tunable porosities, structural diversity, and multi-functionality. MOFs' external surface modifications endow them with new properties functions, such hydrophilicity, colloidal stability, controlled payload release, specific targeted delivery, biocompatibility. These attributes greatly improve the performance use of MOFs diagnosis treatment several diseases. In this review, we aim offer an up-to-date comprehensive assessment current advances in development functionalization MOFs, from design application. This review summarizes engineering approaches, highlighting representative examples successful healthcare applications. Finally, discuss remaining challenges limitations field while foresighted ideas future research directions.
Language: Английский
Citations
43