A Multifunctional Exosome with Dual Homeostasis Disruption Augments cGAS-STING-Mediated Tumor Immunotherapy by Boosting Ferroptosis DOI

Xiao-Qing Wei,

Ling Sun, Jun Deng

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14263 - 14272

Published: Oct. 30, 2024

Ferroptosis has shown great potential in activating antitumor immunity. However, the cunning tumor cells can evade ferroptosis by increasing efflux of iron and promoting production reductant glutathione to mitigate oxidative stress. Herein, a multifunctional exosome loaded with manganese-doped oxide nanoparticles (MnIO), GW4869, l-buthionine sulfoximine (BSO) is developed disrupt metabolism homeostasis redox enhance immunotherapy. The efficient transport MnIO exosomes inhibition exocytosis GW4869 led high retention up 29.57% ID/g for tumors. Such iron, combination BSO-induced disruption homeostasis, effectively promotes cells. Consequently, that noticeably dual provoke cGAS-STING-based immune response suppress growth lung metastasis orthotopic breast cancer.

Language: Английский

Engineered Bio‐Based Hydrogels for Cancer Immunotherapy DOI
Yuxuan Peng, Shuang Liang, Qian‐Fang Meng

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 16, 2024

Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.

Language: Английский

Citations

24
Black Phosphorus Quantum Dot Loaded Bioinspired Nanoplatform Synergized with aPD-L1 for Multimode Cancer Immunotherapy DOI

Yuqi Cao,

Lu Tang,

Cong Fu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(22), P. 6767 - 6777

Published: May 21, 2024

Efforts to prolong the blood circulation time and bypass immune clearance play vital roles in improving therapeutic efficacy of nanoparticles (NPs). Herein, a multifunctional nanoplatform (BPP@RTL) that precisely targets tumor cells is fabricated by encapsulating ultrasmall phototherapeutic agent black phosphorus quantum dot (BPQD), chemotherapeutic drug paclitaxel (PTX), immunomodulator PolyMetformin (PM) hybrid membrane-camouflaged liposomes. Specifically, cell membrane coating derived from fusion cancer red displays excellent targeting efficiency long property due innate features both membranes. After collaboration with aPD-L1-based checkpoint blockade therapy, boosted immunotherapeutic effect obtained elevated dendritic maturation T activation. Significantly, laser-irradiated BPP@RTL combined aPD-L1 effectively eliminates primary tumors inhibits lung metastasis 4T1 breast model, offering promising treatment plan develop personalized antitumor strategy.

Language: Английский

Citations

17
A pH-Responsive and Guanidinium-Rich Nanoadjuvant Efficiently Delivers STING Agonist for Cancer Immunotherapy DOI

Xiao Juan Lu,

Heming Xia, Wei Gao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

As natural agonists of the stimulator interferon genes (STING), cyclic dinucleotides (CDNs) have been identified as promising immunotherapies that trigger a potent immune response against tumors. However, low stability, rapid clearance, inadequate cellular uptake, and inefficient cytosol localization heavily hinder therapeutic efficacy hydrophilic negatively charged 2′, 3′-cyclic-GMP-AMP (cGAMP). How to efficiently deliver cGAMP into endoplasmic reticulum (ER) activate STING for priming remains challenging. Here, we report pH-responsive guanidinium-rich nanoagonist (nPGSA) delivery cGAMP. Compared with free cGAMP, nPGSA achieves up 37.4-fold enhancement internalization. The pH-sensitive guanidinium-functional design facilitates quick release endosome escape, thus enabling precise ER targeting 33.9-fold amplification sensibilization. Furthermore, through modulation tumor-associated macrophage (TAM) polarization, elicits antigen-specific sustained tumor regression in melanoma- neuroblastoma-bearing mice. Our study provides strategy it offers insights function modulating microenvironment cancer immunotherapy.

Language: Английский

Citations

2
Zinc‐Based ROS Amplifiers Trigger Cancer Chemodynamic/Ion Interference Therapy Through Self‐Cascade Catalysis DOI
Yun Sun, Liting Qin, Yuhan Yang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract Nanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H 2 O ) levels in microenvironment (TME) poses challenges. Herein, an H self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc (ZnO (denoted ZnO @Pt). releases response acidic TME. Pt NPs catalyze hydroxyl radical generation from while reducing mitigation of oxidative stress glutathione, serving reactive oxygen (ROS) amplifier self‐cascade catalysis. In addition, Zn 2+ released interferes with cell energy supply metabolism, enabling ion interference synergize therapy. vitro studies demonstrate that @Pt induces cellular injury enhanced ROS release, downregulating ATP NAD + levels. vivo assessment anticancer effects showed could generate at sites induce apoptosis downregulate pathways associated glycolysis, resulting 89.7% reduction growth. This study presents TME‐responsive capable self‐supply therapy, providing paradigm for tumor‐specific design.

Language: Английский

Citations

12
Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy DOI Creative Commons
Yuxuan Peng,

Shuang Liang,

Dan Liu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

The highly immunosuppressive tumor microenvironment (TME) restricts the efficient activation of immune responses. To restore surveillance system for robust activation, vast efforts are devoted to normalizing TME. Here, a manganese-doped layered double hydroxide (Mn-LDH) is developed potent anti-tumor immunity by reversing Mn-LDH synthesized via one-step hydrothermal method. In addition inherent proton neutralization capacity LDH, introduction manganese oxide endows LDH with an additional ability produce oxygen. effectively releases Mn

Language: Английский

Citations

9
Exploring the Potential of Nanocarriers for Cancer Immunotherapy: Insights into Mechanism, Nanocarriers, and Regulatory Perspectives DOI

Tanmoy Kanp,

Anish Dhuri,

M Bharath

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Immunotherapy is a cutting-edge approach that leverages sophisticated technology to target tumor-specific antibodies and modulate the immune system eradicate cancer enhance patients' quality of life. Bioinformatics genetic science advancements have made it possible diagnose treat patients using immunotherapy technology. However, current immunotherapies against limited clinical benefits due cancer-associated antigens, which often fail interact with cells exhibit insufficient therapeutic targeting unintended side effects. To surmount this challenge, nanoparticle systems emerged as potential strategy for transporting immunotherapeutic agents activating combat tumors. Consequently, process potentially generates an antigen-specific T response effectively suppresses growth. Furthermore, nanoplatforms high specificity, efficacy, diagnostic potential, imaging capabilities, making them promising tools treatment. informative paper delves into various available immunotherapies, including CAR therapy checkpoint blockade, cytokines, vaccines, monoclonal antibodies. concept theragnostic nanotechnology, integrates diagnostics more personalized treatment therapy. Additionally, covers different nanocarrier systems, marketed products, trials, regulatory considerations, future prospects immunotherapy.

Language: Английский

Citations

1
Acidic biofilm microenvironment-responsive ROS generation via a protein nanoassembly with hypoxia-relieving and GSH-depleting capabilities for efficient elimination of biofilm bacteria DOI
Junqin Li,

Mengya Sun,

Xiaoxian Tang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 186, P. 439 - 453

Published: Aug. 2, 2024

Language: Английский

Citations

8
Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction DOI Creative Commons
Honglei Hu,

Shuting Zheng,

Chenxi He

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 9, 2024

Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO 2 ) that was core coated with MnO shell followed by glucose oxidase (GOx) doping nanoplatform @MnO @GOx, HMG) to trigger ferroptosis adjuvant effects glutathione depletion and reactive oxygen species production. This cascade potentiation further sensitized radiotherapy enhancing DNA damage in 4T1 breast tumor cells. The combination of HMG nanoparticles effectively activated the damaged Mn 2+ -mediated cGAS-STING pathway vitro vivo. process had significant inhibitory on progression initiating an anticancer systemic response prevent distant recurrence achieve long-lasting suppression both primary tumors. Furthermore, as-prepared “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, demonstrated favorable contrast enhancement capabilities under GSH microenvironment. result highlighted potential as theranostic achieving molecular guided sensitization induced synergistic immunotherapy.

Language: Английский

Citations

7
Inorganic Nanoparticle Functionalization Strategies in Immunotherapeutic Applications DOI Creative Commons
Wei Mao, Hyuk Sang Yoo

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Language: Английский

Citations

6
Design Principles for Immunomodulatory Biomaterials DOI

Samuel Abidemi Oluwole,

Welday Desta Weldu,

Keerthana Jayaraman

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

The immune system is imperative to the survival of all biological organisms. A functional protects organism by detecting and eliminating foreign host aberrant molecules. Conversely, a dysfunctional characterized an overactive or weakened causes life-threatening autoimmune immunodeficiency diseases. Therefore, critical need exists develop technologies that regulate ensure homeostasis treat several Accumulating evidence shows biomaterials─artificial materials (polymers, metals, ceramics, engineered cells tissues) interact with systems─can trigger responses, offering science-based strategy modulate system. This Review discusses expanding frontiers biomaterial-based immunomodulation, focusing on principles for designing these materials. also presents examples immunomodulatory biomaterials, which include polymers metal- carbon-based nanomaterials, capable regulating innate adaptive systems.

Language: Английский

Citations

5