Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Cancer
immunotherapy
holds
significant
promise
for
improving
cancer
treatment
efficacy;
however,
the
low
response
rate
remains
a
considerable
challenge.
To
overcome
this
limitation,
advanced
catalytic
materials
offer
potential
in
augmenting
by
modulating
immunosuppressive
tumor
microenvironment
(TME)
through
precise
biochemical
reactions.
Achieving
optimal
targeting
precision
and
therapeutic
efficacy
necessitates
thorough
understanding
of
properties
underlying
mechanisms
tumor-targeted
materials.
This
review
provides
comprehensive
systematic
overview
recent
advancements
their
critical
role
enhancing
immunotherapy.
It
highlights
types
reactions,
construction
strategies
materials,
fundamental
targeting,
including
passive,
bioactive,
stimuli-responsive,
biomimetic
approaches.
Furthermore,
outlines
various
tumor-specific
strategies,
encompassing
tissue,
cell,
exogenous
TME-responsive,
cellular
TME
strategies.
Finally,
discussion
addresses
challenges
future
perspectives
transitioning
into
clinical
applications,
offering
insights
that
pave
way
next-generation
therapies
provide
substantial
benefits
to
patients
settings.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Plant
polyphenol-based
hydrogels,
known
for
their
biocompatibility
and
adhesive
properties,
have
emerged
as
promising
materials
in
biomedical
applications.
These
hydrogels
leverage
the
catechol
group's
ability
to
form
stable
bonds
moist
environments,
similar
mussel
proteins.
This
review
provides
a
comprehensive
overview
of
synthesis,
adhesion
mechanisms,
applications,
particularly
wound
healing,
tissue
regeneration,
drug
delivery.
However,
challenges
related
vivo
stability
long-term
remain
critical
barriers
clinical
translation.
Future
research
should
focus
on
enhancing
bioactivity,
biocompatibility,
scalability
these
while
addressing
concerns
toxicity,
immune
responses,
large-scale
manufacturing.
Advances
artificial
intelligence-assisted
screening
3D/4D
bioprinting
are
expected
accelerate
development
Furthermore,
integration
biomimetic
designs
responsive
functionalities,
such
pH
or
temperature
sensitivity,
holds
promise
further
improving
therapeutic
efficacy.
In
conclusion,
multifunctional
plant
represents
frontier
advancing
personalized
medicine
minimally
invasive
treatments.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(52), P. 35465 - 35479
Published: Dec. 16, 2024
Polymer
aerogels,
with
their
porous
and
lightweight
features,
excel
in
applications
such
as
energy
storage,
absorption,
thermal
insulation,
making
them
a
sought-after
new
material.
However,
the
covalent
cross-linking
networks
of
current
polymer
aerogels
result
unsustainable
manufacturing
processing
practices,
persistently
depleting
our
finite
natural
resources
causing
significant
global
environmental
impacts.
Herein,
we
have
constructed
high-performance
dynamic
aerogel
network
using
biobased
materials,
its
structure
green
sustainability
akin
to
those
plants
nature.
Abundant
reversible
points
endow
ultrafast
degradation
capabilities,
enabling
allow
for
closed-loop
chemical
monomer
recovery
reprocessing.
Furthermore,
utilizing
highly
active
network,
net-zero
emission
material
reuse
reprocessing
can
be
achieved.
Additionally,
controlled
features
multilevel
roughness
nanostructured
surface
similar
lotus
leaf
biomimetic
pore
structure,
contributing
anisotropy.
The
distinctive
composition
high
compressive
strength
(2.2
MPa)
vertically,
low
conductivity
(0.0257
W/(m·K))
horizontally,
outstanding
fire
resistance
(LOI
is
36%).
Notably,
demonstrates
highest
hydrophobicity
among
polyimine
contact
angle
154°.
excellent
performance
variety
potential
oil–water
separation,
directional
transport,
phase
change
it
anticipated
that
these
will
greatly
benefit
from
systematic
upgrades
recyclability
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(16), P. 8568 - 8579
Published: April 9, 2024
Based
on
the
typical
similar
repeat
units
(abcdefg)n
of
α-helical
structure,
peptide
H
was
designed
to
self-assemble
into
an
organohydrogel
in
response
pH.
Depending
different
pH,
proportions
secondary
microstructure,
and
mechanical
properties
gel
were
investigated.
Circular
dichroism
(CD)
Fourier
transform
infrared
(FT-IR)
showed
that
proportion
structure
gradually
increased
become
dominant
with
increase
Combining
transmission
electron
microscopy
(TEM)
atomic
force
(AFM),
it
found
ordered
α-helix
promoted
fiber
formation.
The
further
pH
changed
intermolecular
forces,
resulting
content
enhancement
helix–helix
interaction,
causing
fibers
converge
thicker
more
dense
ones.
temperature
test
stable
rheological
between
20–60
°C.
Drug
release
cytotoxicity
DOX-loaded
could
have
a
better
acidic
environment,
indicating
its
potential
application
as
drug
local
delivery
carrier.
Small,
Journal Year:
2024,
Volume and Issue:
20(45)
Published: July 25, 2024
Abstract
Immune
checkpoint
inhibitors
(ICIs)
offer
promise
in
breaking
through
the
treatment
and
survival
dilemma
of
triple‐negative
breast
cancer
(TNBC),
yet
only
immunomodulatory
subtype
≈5%
TNBC
patients
respond
as
monotherapy
due
to
lack
effector
immune
cells
(internal
problem)
physical
barrier
(external
limitation)
formed
by
cancer‐associated
fibroblasts
(CAFs).
A
hydrogel
drug‐delivery
platform,
ALG@TBP‐2/Pt(0)/nintedanib
(ALG@TPN),
is
designed
induce
strong
functions
dual
elimination
internal
external
tumor
microenvironment
(TME).
Activated
white
light,
type
I
II
photodynamic
therapy
(PDT),
TBP‐2
generates
large
amounts
reactive
oxygen
species
(ROS)
intracellularly,
oxidizing
mitochondrial
DNA
(mtDNA).
The
unique
catalase
activity
Pt(0)
converts
endogenous
H
2
O
,
reducing
anoxia‐limiting
PDT
enhancing
ROS
generation
efficacy.
Abundant
can
oxidize
cytotoxic
Pt(II),
damaging
nuclear
(nDNA).
Dual
damage
mtDNA
nDNA
might
bi‐directionally
activate
cGAS/STING
pathway
enhance
cell
response.
Besides,
nintedanib
demonstrates
a
significant
inhibitory
effect
on
CAFs,
weakening
deepening
infiltration.
Overall,
study
provides
self‐oxygenating
with
“PDT/chemotherapy/anti‐CAFs”
effect,
triggering
reshape
TME.
Both
interventions
increase
anti‐TNBC
responses.
Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Sept. 10, 2024
The
unavoidable
residual
tumor
tissue
from
surgery
and
the
strong
aggressiveness
of
cells
pose
challenges
to
postoperative
treatment
patients,
accompanied
by
in
situ
recurrence
decreased
quality
life.
Therefore,
there
is
an
urgent
need
explore
appropriate
therapeutic
strategies
remove
after
inhibit
metastasis
surgery.
In
recent
years,
with
rapid
development
biomedical
materials,
study
local
delivery
systems
as
agents
has
gradually
attracted
attention
researchers.
Injectable
situ-forming
hydrogel
a
locally
administered
agent
injected
solution
that
can
be
loaded
various
rapidly
gels
form
semi-solid
gel
at
site.
This
type
tightly
fills
surgical
site
covers
irregular
excision
surfaces.
this
paper,
we
review
advances
application
injectable
hydrogels
therapy,
focusing
on
matrix
materials
its
different
types
tumors,
well
discussing
prospects
clinical
application.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Abstract
Cisplatin
is
widely
used
in
clinical
cancer
treatment;
however,
its
application
often
hindered
by
severe
side
effects,
particularly
inherent
or
acquired
resistance
of
target
cells.
To
address
these
challenges,
an
effective
strategy
to
modify
the
metal
core
complex
and
introduce
alternative
coordination
modes
valence
states,
leading
development
a
series
complexes,
such
as
platinum
(IV)
prodrugs
cyclometalated
complexes.
Recent
advances
nanotechnology
have
facilitated
multifunctional
nanomaterials
that
can
selectively
deliver
drugs
tumor
cells,
thereby
overcoming
pharmacological
limitations
metal‐based
drugs.
This
review
first
explores
self‐assembly
complexes
into
spherical,
linear,
irregular
nanoparticles
context
biomedical
applications.
The
mechanisms
underlying
are
subsequently
analyzed,
followed
discussion
their
applications
fields,
including
detection,
imaging,
antitumor
research.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Hydrogels
in
water
or
aqueous
solutions
swell
shrink
unidirectionally
until
reaching
an
equilibrium
state,
which
has
been
extensively
studied
through
both
experimental
analysis
and
theoretical
prediction.
In
this
work,
unexpected
concurrent
swelling
deswelling
behavior
of
hydrogels
is
reported,
manipulates
the
state
polymer
networks.
The
osmotic
pressure‐driven
rapid
ionic
electrostatic
repulsion‐driven
slow
occur
simultaneously,
affording
double‐layered
polyacrylamide
(PAM)
hydrogels,
rigid
inner
layer
does
not
contains
free
water,
while
soft
outer
comprises
bound
water.
PAM
show
uniaxial
tensile
fracture
strengths
Young's
moduli
up
to
104.2
MPa
2.4
GPa,
respectively,
outperforming
various
polymeric
biological
structural
materials.
This
strategy
applicable
general
molding
three‐dimensional
(3D)
printing
techniques,
providing
wide
possibilities
for
engineering
applications.
Such
strong
can
simultaneously
serve
as
materials
load‐bearing
act
functional
super‐stress
(25
6000
N)
highly
adaptable
tactile
sensing.
These
findings
enrich
hydrogel
swell/deswelling
theory
broaden
applications
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 141 - 141
Published: Feb. 17, 2025
Injectable
recombinant
collagen
hydrogels
(RCHs)
are
crucial
in
biomedical
applications.
Culture
conditions
play
an
important
role
the
preparation
of
hydrogels.
However,
determining
characteristics
under
certain
and
optimal
swiftly
still
remain
challenging
tasks.
In
this
study,
a
machine
learning
approach
was
introduced
to
explore
correlation
between
hydrogel
culture
determine
conditions.
The
study
focused
on
four
key
factors
as
independent
variables:
initial
substrate
concentration,
reaction
temperature,
pH
level,
time,
while
dependent
variable
elastic
modulus
To
analyze
impact
these
modulus,
mathematical
models
were
employed,
including
multiple
linear
regression
(ML),
decision
tree
(DT),
support
vector
(SVM),
neural
network
(NN).
theoretical
outputs
NN
closest
actual
values.
Therefore,
proved
be
most
suitable
model.
Subsequently,
identified
concentration
15%
(W/V),
temperature
4
°C,
7.0,
time
12
h.
prepared
specific
exhibited
predicted
15,340
Pa,
approaching
that
natural
cartilage.
