Mechanical
stiffness
of
liver
organoid
is
a
key
indicator
for
the
progress
hepatic
steatosis.
Probe
indentation
noninvasive
methodology
to
measure
Young's
modulus
(YM);
however,
inhomogeneous
nature
induces
measurement
uncertainty
requiring
large
number
indentations
covering
wide
scanning
area.
Here,
we
demonstrate
that
lipid-stained
fluorescence
imaging-assisted
probe
significantly
reduces
measurements
by
specifying
highly
lipid-induced
Lipid-stained
steatosis
model
shows
broad
distributions
are
spatially
correlated
with
decreased
YM
on
lipid-filled
region
bright
compared
measured
blank
dark
fluorescence.
The
viability
remained
robust
even
after
exposure
an
ambient
condition
up
6
h,
showing
can
be
methods
measurements.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(12), P. 3631 - 3637
Published: March 11, 2024
A
striking
phenomenon
of
collective
cell
motion
is
that
they
can
exhibit
a
spontaneously
emerging
wave
during
epithelia
expansions.
However,
the
fundamental
mechanism,
governing
emergence
and
its
crucial
characteristics
(e.g.,
eigenfrequency
pattern),
remains
an
enigma.
By
introducing
mechanochemical
feedback
loop,
we
develop
highly
efficient
discrete
vertex
model
to
investigate
spatiotemporal
evolution
spreading
epithelia.
We
find
both
numerically
analytically
expanding
monolayers
display
power-law
dependence
frequency
on
local
heterogeneities
(i.e.,
density)
with
scaling
exponent
−1/2.
Moreover,
our
study
demonstrates
quantitative
capability
proposed
in
capturing
distinct
X-,
W-,
V-mode
patterns.
unveil
phase
transition
between
these
modes
governed
by
distribution
active
self-propulsion
forces.
Our
work
provides
avenue
for
rigorous
investigations
into
pattern
formation
groups.
Mechanobiology in Medicine,
Journal Year:
2024,
Volume and Issue:
2(3), P. 100079 - 100079
Published: May 16, 2024
Mechanical
stimuli
are
known
to
play
critical
roles
in
mediating
tissue
repair
and
regeneration.
Recently,
this
knowledge
has
led
a
paradigm
shift
toward
proactive
programming
of
biological
functionalities
biomaterials
by
leveraging
mechanics–geometry–biofunction
relationships,
which
beginning
shape
the
newly
emerging
field
mechanobiomaterials.
To
profile
field,
article
aims
elucidate
fundamental
principles
modulating
responses
with
material–tissue
mechanical
interactions,
illustrate
recent
findings
on
relationships
between
material
properties
responses,
discuss
importance
mathematical/physical
models
numerical
simulations
optimizing
geometry,
outline
design
strategies
for
mechanobiomaterials
their
potential
Given
that
is
still
its
infancy,
also
discusses
open
questions
challenges
need
be
addressed.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2576 - 2576
Published: May 30, 2024
Chronic
kidney
disease
(CKD)
presents
a
formidable
global
health
concern,
affecting
one
in
six
adults
over
25.
This
review
explores
the
potential
of
phenolic
compounds
managing
CKD
and
its
complications.
By
examining
existing
research,
we
highlight
their
diverse
biological
activities
to
combat
CKD-related
issues.
We
analyze
nutritional
benefits,
bioavailability,
safety
profile
these
compounds.
While
clinical
evidence
is
promising,
preclinical
studies
offer
valuable
insights
into
underlying
mechanisms,
optimal
dosages,
side
effects.
Further
research
crucial
validate
therapeutic
efficacy
for
CKD.
advocate
continued
exploration
innovative
applications
food,
pharmaceuticals,
nutraceuticals.
aims
catalyze
scientific
community's
efforts
leverage
against
challenges.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(8), P. 747 - 747
Published: July 24, 2024
Pulmonary
fibrosis
is
a
fatal
lung
disease
affecting
approximately
5
million
people
worldwide,
with
5-year
survival
rate
of
less
than
50%.
Currently,
the
only
available
treatments
are
palliative
care
and
transplantation,
as
there
no
curative
drug
for
this
condition.
The
involves
excessive
synthesis
extracellular
matrix
(ECM)
due
to
alveolar
epithelial
cell
damage,
leading
scarring
stiffening
tissue
ultimately
causing
respiratory
failure.
Although
multiple
factors
contribute
disease,
exact
causes
remain
unclear.
mechanical
properties
tissue,
including
elasticity,
viscoelasticity,
surface
tension,
not
affected
by
but
also
its
progression.
This
paper
reviews
alteration
in
these
pulmonary
progresses
how
cells
lung,
cells,
fibroblasts,
macrophages,
respond
changes,
contributing
exacerbation.
Furthermore,
it
highlights
importance
developing
advanced
vitro
models,
based
on
hydrogels
3D
bioprinting,
which
can
accurately
replicate
structural
fibrotic
lungs
conducive
studying
effects
stimuli
cellular
responses.
review
aims
summarize
current
understanding
interaction
between
progression
alterations
properties,
could
aid
development
novel
therapeutic
strategies
disease.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(45), P. 14522 - 14530
Published: Nov. 4, 2024
The
mechanical
and
electrical
properties
of
cells
serve
as
critical
indicators
their
physiological
pathological
state.
Currently,
distinct
setups
are
required
to
measure
the
responses
cells.
In
addition,
most
existing
methods
such
optical
trapping
(OT)
atomic
force
microscopy
(AFM)
labor-intensive,
expensive,
low-throughput.
Here,
we
developed
a
microdevice
that
integrates
automated
cell
trapping,
deformation,
electric
impedance
spectroscopy
overcome
these
limitations.
Our
device
enables
parallel
aspiration
tens
trapped
in
highly
scalable
manner
by
simply
adjusting
applied
pressures,
allowing
for
rapid
probing
dynamic
viscoelastic
Furthermore,
embedded
microelectrodes
enable
concurrent
investigations
Through
testing
on
different
types,
our
platform
demonstrated
superior
capabilities
comprehensive
characterization
phenotyping,
highlighting
its
great
potential
versatile
tool
single
analysis,
drug
screening,
disease
detection.
Viscoelasticity
is
the
mechanical
feature
of
living
tissues
and
cellular
extracellular
matrix
(ECM)
has
been
recognized
as
an
essential
biophysical
cue
in
cell
function
fate
regulation,
tissue
development
homeostasis
maintenance,
disease
progression.
These
findings
provide
new
insights
for
biomaterials
with
comparable
viscoelastic
properties
native
ECMs
matrix,
displaying
promising
applications
regeneration
medicine.
In
this
review,
relationship
between
viscoelasticity
functions
(e.g.,
regeneration)
physiological
conditions
progression
aging,
degenerative,
fibrosis,
tumor)
pathological
will
be
especially
highlighted
to
figure
out
potential
therapeutic
target
treatment
inspiration
related
biomaterial
development.
Furthermore,
understanding
response
ECM
mechanism
behind
it
are
comprehensively
summarized
a
pathophysiological
basis
design.
The
advances
on
defect
repair
also
reviewed,
suggesting
significance
matchable
microenvironment
regeneration.
Although
challenging,
tunable
that
match
show
great
promise.
They
could
promote
regeneration,
treat
degenerative
diseases,
support
organoids
artificial
organs.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 457 - 457
Published: March 21, 2025
In
the
presence
of
cellular
mutations
and
impaired
mechanisms
energy
transmission
to
attached
cells
tissues,
excess
is
available
upregulate
some
mechanotransduction
pathways
that
maintain
cell
tissue
structure
function.
The
ability
transfer
applied
through
integrin-mediated
pathways,
ion
channels,
membrane,
cytoskeleton-nucleoskeleton
connections,
junctions,
cell-extracellular
matrix
attachments
provides
an
equilibrium
for
storage,
transmission,
dissipation
in
tissues.
Disruption
or
via
genetic
blocks
mechanical
communication
between
tissues
impairs
exists
This
results
local
structural
changes
altered
regulatory
which
produce
clustering,
collagen
encapsulation,
epithelial-mesenchymal
transition
(EMT),
leading
increased
motility
along
newly
reorganized
fibers
(fibrosis).
goal
this
review
postulate
how
extracellular
may
alter
pathways.
with
lead
ECM
reported
cancer,
postulated
modify
equilibria
their
ECM.
leads
uncontrolled
cancer
proliferation
remodeling.
