Harnessing Cross-strand π–π Interlocking for Synergistic Enhancement of Immune Checkpoint Blocking and Ferroptosis DOI
Limin Zhang, Xin Wang, Jinge Zhao

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

The dynamic nature of noncovalent bonds in peptide self-assembly allows for selective accommodation guest molecules. However, it remains unclear how to harness coassembly reinforce the host peptides and simultaneously improve application defects This study aims achieve supramolecular synergy between guest, further expanding functional space hybrid nanostructures. Herein, we utilized aromatic regions present β-sheet accommodate molecules, forming long-range nanotubes (NQ40@AIF) through a unique 'cross-strand π-π interlocking'. strategy not only stabilizes effectively but also synergizes biological functions Moreover, due chemical diversity coassembled NQ40@AIF, exhibits advantages tumor combination therapy, achieving effective ferroptosis immune checkpoint blocking. work provides minimalistic constructing nanostructures with complex functionalities.

Language: Английский

Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines DOI Creative Commons
Wen‐Jing Xiao, Wenjie Jiang, Zheng Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 5, 2025

The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. integration novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, artificial intelligence have significantly expedited the development groundbreaking drugs, effectively addressing obstacles associated with their character, such as rapid clearance degradation, necessitating subcutaneous injection leading increasing patient discomfort, ultimately advancing translational research efforts. Peptides are presently employed in management diagnosis diverse array medical conditions, diabetes mellitus, weight loss, oncology, rare diseases, additionally garnering interest facilitating targeted platforms advancement vaccines. This paper provides an overview present market clinical trial progress therapeutics, platforms, It examines key areas through literature analysis emphasizes structural modification principles well recent advancements screening, design, technologies. accelerated including peptide-drug complexes, new vaccines, innovative diagnostic reagents, has potential promote era precise customization disease therapeutic schedule.

Language: Английский

Citations

5
Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Citations

11
Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases DOI
Shuoxun Zhang, Huapan Fang,

Huayu Tian

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7015 - 7057

Published: Oct. 18, 2024

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation

Language: Английский

Citations

6
Photothermal-Magnetic Driven Post-Targeting Retention and Cascade Therapy of “Biomimetic Glue”-Based Nanoreactor for Cancer Theranostics by Bystander-Like Killing DOI
Zihan Liu, Ting Yang,

Jiale Miao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Citations

0
Photothermal-magnetic driven post-targeting retention and cascade therapy of “biomimetic glue”-based nanoreactor for cancer theranostics by bystander-like killing DOI
Zihan Liu, Ting Yang,

Jiale Miao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162784 - 162784

Published: April 1, 2025

Language: Английский

Citations

0
Smart Molecular Imaging and Theranostic Probes by Enzymatic Molecular In Situ Self-Assembly DOI Creative Commons

Xidan Wen,

Chao Zhang, Yuyang Tian

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(7), P. 2426 - 2450

Published: July 3, 2024

Enzymatic molecular in situ self-assembly (E-MISA) that enables the synthesis of high-order nanostructures from synthetic small molecules inside a living subject has emerged as promising strategy for imaging and theranostics. This leverages catalytic activity an enzyme to trigger probe substrate conversion assembly situ, permitting prolonging retention congregating many probes targeted cells or tissues. Enhanced signals therapeutic functions can be achieved by responding specific enzyme. E-MISA been successfully applied development enzyme-activated smart theranostic vivo applications. In this Perspective, we discuss general principle controlling then applications construction "smart" against cancers bacteria. Finally, current challenges perspectives utilizing disease diagnoses therapies, particularly clinical translation.

Language: Английский

Citations

2
Protease-Responsive Bitext Editing Biopolymer for Breast Cancer Imaging In Vivo DOI

Yixi Dong,

Gang Wang, Noshin Afshan

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: unknown, P. 3815 - 3823

Published: July 23, 2024

Language: Английский

Citations

1
Harnessing Cross-strand π–π Interlocking for Synergistic Enhancement of Immune Checkpoint Blocking and Ferroptosis DOI
Limin Zhang, Xin Wang, Jinge Zhao

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

The dynamic nature of noncovalent bonds in peptide self-assembly allows for selective accommodation guest molecules. However, it remains unclear how to harness coassembly reinforce the host peptides and simultaneously improve application defects This study aims achieve supramolecular synergy between guest, further expanding functional space hybrid nanostructures. Herein, we utilized aromatic regions present β-sheet accommodate molecules, forming long-range nanotubes (NQ40@AIF) through a unique 'cross-strand π-π interlocking'. strategy not only stabilizes effectively but also synergizes biological functions Moreover, due chemical diversity coassembled NQ40@AIF, exhibits advantages tumor combination therapy, achieving effective ferroptosis immune checkpoint blocking. work provides minimalistic constructing nanostructures with complex functionalities.

Language: Английский

Citations

1