Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy DOI

Cong Fu,

Lu Tang,

Yuqi Cao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156420 - 156420

Published: Oct. 5, 2024

Language: Английский

Endothelium-Targeted NF-κB siRNA Nanogel for Magnetic Resonance Imaging and Visualized-Anti-inflammation Treatment of Atherosclerosis DOI Creative Commons
Yuanyuan Guo, Fujun Wang,

Sunli Wan

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122897 - 122897

Published: Oct. 17, 2024

Language: Английский

Citations

4
Bibliometric analysis of metformin as an immunomodulator (2013–2024) DOI Creative Commons

Tongyi Zhou,

Yunfeng Yu,

Qi Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited. This study extracted 640 relevant articles from Web of Science (WOS) Core Collection and conducted visual using Microsoft Excel, VOSviewer, CiteSpace. The findings showed that research immunomodulatory function metformin grown steadily since 2017, with China United States being leading contributors. These studies have mostly been published in journals such International Journal Molecular Sciences, Cancers, Frontiers Immunology, Scientific Reports. Keyword co-occurrence analysis highlighted metformin's role immunomodulator, particularly context tumor immune microenvironment, immunosuppressive checkpoints, derivatives. Recent application aging, autoimmune diseases, COVID-19, tuberculosis. Additionally, its regulating inflammation gut microbiota is also investigated. Overall, effects were investigated anti-tumor, antiviral, anti-aging, disease research. highlights scope use these fields, while significantly enhancing clinical value a repurposed drug.

Language: Английский

Citations

0
Nanomedicines for the treatment of ischemic stroke: an overview of recent advances DOI Creative Commons

Siqi Geng,

Caiyun Zhang, João Rodrigues

et al.

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100022 - 100022

Published: Feb. 1, 2025

Language: Английский

Citations

0
Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage‐Targeted Nanohybrid Systems for Enhancing Tumor Chemo‐Immunotherapy DOI

You‐Teng Qin,

Zhi‐Yong Rao,

Jiaxin An

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Chemotherapy combined with immunotherapy (chemo‐immunotherapy) has emerged as a critical strategy in tumor treatment. However, chemotherapy induced immune tolerance and the immunosuppressive microenvironment limit its effectiveness. Secondary necrosis can generate additional immunogenic substances, enhancing immunogenicity of cells, but macrophage‐mediated clearance apoptotic cells inhibits occurrence secondary necrosis. In this study, tumor‐associated macrophage (TAM)‐targeting nanohybrid system, SC@P@U, is designed by combining poly (lactic‐co‐glycolic acid) (PLGA)‐loaded MerTK inhibitor UNC2025 (P@U) saccharomyces cerevisiae‐derived β‐glucan (SC shell). This system specifically targets TAMs, preventing them from clearing inhibiting their polarization into immune‐suppressive M2 macrophages. More importantly, it activates STING pathway, further stimulating dendritic initiating T cell‐mediated responses. vivo experiments demonstrated that when paclitaxel (PTX), significantly suppressed growth, activated anti‐tumor immunity, and, used conjunction checkpoint αPD‐1, markedly enhanced effect. overcomes traditional chemo‐immunotherapy, reverses microenvironment, offers promising approach to

Language: Английский

Citations

0
Hybrid Nanogel Drug Delivery Systems: Transforming the Tumor Microenvironment through Tumor Tissue Editing DOI Creative Commons
Theodora Katopodi, Savvas Petanidis, George Floros

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 908 - 908

Published: May 24, 2024

The future of drug delivery offers immense potential for the creation nanoplatforms based on nanogels. Nanogels present a significant possibility pharmaceutical advancements because their excellent stability and effective drug-loading capability both hydrophobic hydrophilic agents. As multifunctional systems, composite nanogels demonstrate capacity to carry genes, drugs, diagnostic agents while offering perfect platform theranostic multimodal applications. can achieve diverse responsiveness enable stimuli-responsive release chemo-/immunotherapy drugs thus reprogramming cells within TME in order inhibit tumor proliferation, progression, metastasis. In active targeting boost accumulation at target sites, particular ligands be added improve therapeutic outcomes enhance precision cancer therapy. Modern “immune-specific” also have extra sophisticated tissue-editing properties. Consequently, introduction nanogel-based system improves targeted distribution immunotherapy combinational treatments, thereby increasing effectiveness

Language: Английский

Citations

3
Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy DOI

Cong Fu,

Lu Tang,

Yuqi Cao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156420 - 156420

Published: Oct. 5, 2024

Language: Английский

Citations

3