Journal of Nutrition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73
Published: Jan. 24, 2025
The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 1, 2025
Language: Английский
Citations
3
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101642 - 101642
Published: March 7, 2025
The integration of living microbes, specifically bacteria and fungi, with metal-organic nanocoatings has led to the recent development cyborg microbe biohybrids, which show excellent adaptability functionality for a wide range potential applications in biotechnology medicine. This review discusses strategies, functionalisation, these are categorised into two types coatings: frameworks (MOFs) metal-phenolic networks (MPNs). Key advances their synthetic approaches via in-situ pre-synthesised coatings crucially addressed, yet methodology details specific advantages highlighted. Despite notable advancements, there various limitations challenges, such as determination long-term viability stability insufficient work on theranostic essentially scaling-up difficulties industrial clinical translation. latest advancements biohybrids related technology have established critical foundation enhancing innovative studies through strong interdisciplinary teamwork.
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 538 - 549
Published: Aug. 30, 2024
Language: Английский
Citations
6
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160203 - 160203
Published: Feb. 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160230 - 160230
Published: Feb. 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Ulcerative colitis (UC) is a chronic inflammatory condition that imposes huge healthcare burden globally. The inflamed colon marked by an abundance of positively charged proteins, increased reactive oxygen species (ROS), disrupted intestinal barrier, and imbalanced gut microbiome. Leveraging these features, we designed negatively ROS-responsive nanocarrier using diselenide-bond-modified carboxymethyl cellulose (CMC) for the targeted delivery curcumin, natural ROS-scavenging antioxidant, to treat UC. design rationale encompasses three key aspects: (1) biocompatible biodegradable CMC matrix stabilizes curcumin during digestion; (2) diselenide bonds enable redox-triggered release at sites, ensuring precise therapeutic action; (3) negative charge nanoparticles enhances interactions with proteins in tissues, improving site-specific accumulation. Experimental validation confirmed principles, demonstrating resulting effectively preserve digestion sites. Additionally, interact folic acid receptors (positively proteins) are overexpressed on oxidatively stressed cell membranes, leading specific accumulation tissue. Subsequently, scavenge excessive ROS, restore barrier function, modulate microbiota. These synergistic actions collectively contribute significant mitigation symptoms both preventive regimens, suggesting promising alternative approach
Language: Английский
Citations
0
Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100019 - 100019
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered outdated due to its restricted efficacy unavoidable side effects. Herein, a polynorepinephrine-coated programmable probiotic expressing α-aminoadipate aminotransferase (NE-EcN-pA) was constructed improve the levels kynurenic acid xanthurenic in intestine by modulating endogenous tryptophan metabolism. The NE layer could protect EcN-pA against harsh environment gastrointestinal tract, enhancing survival colonization. In UC mice, oral administration NE-EcN-pA effectively alleviated intestinal inflammation restored epithelial barrier owing activation aryl hydrocarbon receptor pathway. Furthermore, promoted diversity flora, improved imbalance enhanced content short-chain fatty acids colon. Overall, can regulate metabolism gut microbiota, showing promise disorders.
Language: Английский
Citations
0
Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102436 - 102436
Published: April 1, 2025
Language: Английский
Citations
0