Research progress of novel anti-tumor drug formulations DOI Creative Commons
Yan Liu, Qie Guo,

YunYan Shi

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 16, 2024

Cancers have become the second leading cause of death worldwide, following cardiovascular diseases.Traditional anti- cancer strategies, including radiotherapy chemotherapy, surgery, and targeted therapies, been widely used but are often reassessed due to their significant side effects relatively low cure rate. Recently, development novel formulations for anti-tumor drugs has gained considerable attention, marking a pivotal step forward in treatment advancements. These innovative aim enhance therapeutic efficacy by employing advanced drug formulation technologies delivery systems. In particular, nano-drug systems (NDDS) emerged as promising approach improve targeting, reduce effects, overcome resistance. This review highlights recent progress NDDS explores future prospects these improving outcomes.

Language: Английский

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

1
Photothermally Active Quantum Dots in Cancer Imaging and Therapeutics: Nanotheranostics Perspective DOI
Monalisha Debnath, Sayoni Sarkar, Sujit Kumar Debnath

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Cancer is becoming a global threat, as the cancerous cells manipulate themselves frequently, resulting in mutants and more abnormalities. Early-stage real-time detection of cancer biomarkers can provide insight into designing cost-effective diagnostic therapeutic modalities. Nanoparticle quantum dot (QD)-based approaches have been recognized clinically relevant methods to detect disease at molecular level. Over decades, an emergent noninvasive approach, photothermal therapy has evolved eradicate cancer. Moreover, various structures, viz., nanoparticles, clusters, dots, etc., tested bioimaging agents identify tumor selectively. Among them, QDs versatile probes. They attracted enormous attention for imaging applications due their unique colloidal stability, optical physicochemical properties, biocompatibility, easy surface conjugation, scalable production, etc. However, few critical concerns QDs, precise engineering sensing, selective interaction with biological system, associated toxicity, restrict potential intervention curing are yet be explored. According U.S. Food Drug Administration (FDA), there no specific regulation approval nanomedicines. Therefore, these nanomedicines undergo traditional drug, biological, device process. market survey increasing, prospects translational nanomedicine very promising. From this perspective, we discuss importance imaging, usage pertinent cancer, especially its early stages. also rapidly growing view QDs. The long-term safety studies cellular could enhance visibility bring photothermally active clinical stage concurrently FDA approval.

Language: Английский

Citations

5
Recent Progress in Organic–Inorganic Hybrid Perovskites Quantum Dots DOI

Jianguo Cao,

Yue Geng, Lijie Wu

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(17)

Published: May 1, 2025

Abstract Perovskite materials are attractive star in the field of optoelectronics owing to their superior optoelectronic properties, quantum confinement effect, color tunability, high defect tolerance, and photoluminescence yield. Organic‐inorganic hybrid perovskite dots (OIHP‐QDs) have a wide range applications photovoltaic devices, photodetectors, light‐emitting diodes, especially solar cells, LEDs, lasers, due diverse choices organic cations that bring more tunable optical properties them. Here, basic principles, synthesis strategies, research progress, practical OIHP‐QDs based on latest results outlined. This review discusses key challenges limiting factors development while exploring future prospects.

Language: Английский

Citations

0
Long-Term Cell-Membrane-Coated Ultrabright Nanospheres for Targeted Cancer Cell Imaging and Hydrophobic Drug Delivery DOI
Rajendra Prasad,

Berney Peng,

Narendra M. Gupta

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

0
DNA Logic Gate-Triggered Membrane Fusion for Accurately Detecting and Killing Cancer Cells DOI

Chuanye Tang,

Lei Feng, Pinghua Ling

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Accurately and sensitively identifying killing cancer cells, especially those in deep tissues, is of paramount importance but presents significant challenges. Herein, a membrane protein adenosine triphosphate (ATP)-driven DNA logic gate-modified liposome designed to coat zinc peroxide (ZP) nanoparticles integrated with nanozymes (ZP/RuTe@L/DNA) accurately identify induce cell apoptosis cells through reactive oxygen species (ROS)-mediated mechanism under acid conditions cells. In this system, gate-functionalized liposomes are loaded ZP nanozymes, while HeLa functionalized segment that complementary the gate. For gate, aptamer was employed for recognition, another used response extracellular ATP. Activation gate occurs only when both biomarkers simultaneously present. Once activated, could hybridize segment-modified leading liposome-HeLa fusion release ZP/RuTe into Under conditions, decompose H2O2 Zn2+, which promote production •O2- by inhibiting electron transport chain. Concurrently, released RuTe exhibits glutathione (GSH) depletion peroxidase (POD) nicotinamide adenine dinucleotide (NADH) peroxidase-like activities, generating highly toxic hydroxyl radical (•OH), disrupting cellular redox homeostasis, inducing apoptosis. The ZP/RuTe@L/DNA system not detect complex mixtures also present novel method liposome-membrane processes drug delivery. This study potential application precise diagnosis therapy.

Language: Английский

Citations

0
Preferential activation of type I interferon-mediated antitumor inflammatory signaling by CuS/MnO2/diAMP nanoparticles enhances anti-PD-1 therapy for sporadic colorectal cancer DOI Creative Commons
Jinrong Peng, Qian Yang, Rong Lei

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 12, 2024

Converting the "cold" tumor microenvironment (TME) to a "hot" milieu has become prevailing approach for enhancing response of immune-excluded/immunosuppressed colorectal cancer (CRC) patients immune checkpoint blockade (ICB) therapy. During this process, inflammation accompanied by different kinds chemokines/cytokines inevitably occurs. However, some activated inflammatory signals exhibit protumor potency. Therefore, strategies that preferentially activate antitumor signaling rather than tumor-promoting need be developed. Herein, we constructed STING agonist-loaded CuS/MnO

Language: Английский

Citations

2
Molecular Engineering of Ultrabright Biomimetic NanoGhost for Site‐Selective Tumor Imaging and Biodistribution DOI
Rajendra Prasad,

Kumari Prerna,

Mayur Temgire

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Optically active ultrabright imaging agents are shown to delineate tumor location with deep tissue visualization in pre noclinical models. NanoGhosts (NGs) particles reconstructed from the cell membrane and integrated organic fluorophores attain ultra‐brightness for solid imaging. Moreover, integration of amphiphilic lipophilic molecules reveals structural characteristics NGs (≈70 nm), which also alter their brightness. Upon intravenous administration (10 mg kg −1 single dose), these (778 MESF) enable high‐resolution site real‐time tracking vital organs high‐contrast fluorescence signals. Engineered biomimetic demonstrates better resolution penetration as compared clinically approved indocyanine green (ICG). High precision detection (0.5 h) strong retention (24 h is further up 30 th day) without affecting healthy tissues ensure future scope early‐stage cancer These findings suggest that mimic biological native cells, enabling them evade immune clearance target naturally.

Language: Английский

Citations

2
Acoustic waves and smart biomimetic nanoparticles: combination treatment from 2D to 3D colorectal cancer models DOI Creative Commons
Giada Rosso,

Giulia Mesiano,

Bianca Dumontel

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Colorectal Cancer (CRC) is the second leading cause of death among tumors worldwide. Conventional treatments are often accompanied by emerging immunotherapies, trying to reduce burden advanced and metastatic stages. Recently, nanomedicine therapies have been under intensive research offer new perspectives patients. Motivated this rationale, work proposes formulation biomimetic targeted nanoparticles (NPs) enabling a stimuli responsive localized therapy, triggered safe use acoustic shockwaves, deep-penetrating tissue stimulation. Iron-doped zinc oxide nanocrystals were synthetized enveloped in lipid bilayer shell, conjugating peptide (YSA) as selective targeting toward CRC cells. Comparative studies, performed both 2D monolayer 3D spheroids models, between non-targeted (L-ZnO) (YSA-L-ZnO) demonstrated superior capability nanosystems dock be internalized The YSA-L-ZnO proven highly biocompatible hemocompatible, capable inducing damage, once activated shockwaves. This mechanism able synergistically ablate tumor cells proofing concept an innovative stimuli-responsive with strategy future options for cancer fight.

Language: Английский

Citations

1
Research progress of novel anti-tumor drug formulations DOI Creative Commons
Yan Liu, Qie Guo,

YunYan Shi

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 16, 2024

Cancers have become the second leading cause of death worldwide, following cardiovascular diseases.Traditional anti- cancer strategies, including radiotherapy chemotherapy, surgery, and targeted therapies, been widely used but are often reassessed due to their significant side effects relatively low cure rate. Recently, development novel formulations for anti-tumor drugs has gained considerable attention, marking a pivotal step forward in treatment advancements. These innovative aim enhance therapeutic efficacy by employing advanced drug formulation technologies delivery systems. In particular, nano-drug systems (NDDS) emerged as promising approach improve targeting, reduce effects, overcome resistance. This review highlights recent progress NDDS explores future prospects these improving outcomes.

Language: Английский

Citations

0