Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance
Zhijie Xu,
No information about this author
Zhou Hai-yan,
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Tongfei Li
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et al.
Drug Resistance Updates,
Journal Year:
2024,
Volume and Issue:
75, P. 101098 - 101098
Published: June 1, 2024
Language: Английский
Recent Progress in Cancer Vaccines and Nanovaccines
Kishwor Poudel,
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Tulasi Vithiananthan,
No information about this author
Jong Oh Kim
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et al.
Biomaterials,
Journal Year:
2024,
Volume and Issue:
314, P. 122856 - 122856
Published: Sept. 28, 2024
Language: Английский
Iron‐Based Nanomaterials for Modulating Tumor Microenvironment
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 1, 2025
ABSTRACT
Iron‐based
nanomaterials
(IBNMs)
have
been
widely
applied
in
biomedicine
applications
including
magnetic
resonance
imaging,
targeted
drug
delivery,
tumor
therapy,
and
so
forth,
due
to
their
unique
magnetism,
excellent
biocompatibility,
diverse
modalities.
Further
research
on
its
enormous
biomedical
potential
is
still
ongoing,
new
features
are
constantly
being
tapped
demonstrated.
Among
them,
various
types
of
IBNMs
demonstrated
significant
cancer
therapy
capabilities
by
regulating
the
microenvironment
(TME).
In
this
review,
a
variety
iron
oxide‐based
(IONMs),
iron‐based
complex
conjugates
(ICCs),
single
atom
(ISANMs)
will
be
introduced,
advantages
TME
would
also
emphasized.
Besides,
recent
progress
for
diagnosis
treatment
through
strategy
modulating
summarized,
overcoming
hypoxia,
acidity,
decreasing
redox
species,
immunoregulation.
Finally,
challenges
opportunities
field
briefly
discussed.
This
review
expected
contribute
future
design
development
next‐generation
TME‐modulate
treatment.
Language: Английский
Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(2), P. 122 - 122
Published: Jan. 16, 2025
Nano-oncologic
vaccines
represent
a
groundbreaking
approach
in
the
field
of
cancer
immunotherapy,
leveraging
unique
advantages
nanotechnology
to
enhance
effectiveness
and
specificity
treatments.
These
utilize
nanoscale
carriers
deliver
tumor-associated
antigens
immunostimulatory
adjuvants,
facilitating
targeted
immune
activation
promoting
robust
antitumor
responses.
By
improving
antigen
presentation
localizing
within
tumor
microenvironment,
nano-oncologic
can
significantly
increase
efficacy
particularly
when
combined
with
other
treatment
modalities.
This
review
highlights
mechanisms
through
which
operate,
their
potential
overcome
existing
limitations
treatment,
ongoing
advancements
design.
Additionally,
it
discusses
delivery
approach,
such
as
EPR
effects,
pH
response,
ultrasonic
magnetic
response.
The
combination
therapy
effects
photothermal
therapy,
radiotherapy,
or
checkpoint
inhibitors
are
also
discussed.
Overall,
hold
great
promise
for
changing
landscape
advancing
personalized
medicine,
paving
way
more
effective
therapeutic
strategies
tailored
individual
patient
needs.
Language: Английский
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Nanozymes,
which
are
nanomaterials
that
replicate
the
catalytic
activities
of
natural
enzymes
in
biological
systems,
have
recently
demonstrated
considerable
potential
improving
cancer
immunotherapy
by
altering
tumor
microenvironment.
Nanozyme-driven
immune
responses
represent
an
innovative
therapeutic
modality
with
high
effectiveness
and
minimal
side
effects.
These
nanozymes
activate
system
to
specifically
recognize
destroy
cells.
Combined
immunotherapeutic
agents,
can
amplify
anti-cancer
integrating
remodeling
immunogenic
cell
death
(ICD).
This
review
offers
a
thorough
discussion
about
various
involved
immunity,
including
those
mimicking
catalase
(CAT),
superoxide
dismutase
(SOD),
peroxidase
(POD),
oxidase
(OXD).
It
also
discusses
challenges
future
directions
for
translating
nanozyme
platforms
into
clinical
applications,
enhancing
susceptibility
cells
immunotherapy.
Nanozyme-based
strategies
substantial
oncology,
offering
new
effective
options
management.
Language: Английский
Combining oxygen delivery and generation for targeted atherosclerosis therapy
Yujie Wang,
No information about this author
Qun Zhou,
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Le Lü
No information about this author
et al.
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
380, P. 1017 - 1030
Published: Feb. 24, 2025
Hypoxia
plays
an
important
role
in
the
progression
of
atherosclerosis.
However,
ameliorating
hypoxia
at
atherosclerotic
lesions
remains
a
great
challenge.
To
achieve
targeted
oxygen
delivery
to
plaques,
Lipid
5-doped,
platelet
membrane-encapsulated
magnetic
mesoporous
organosilicon
nanoparticles
loaded
with
perfluoro-15-crown
ether
(PFCE)
(FMMON@PL)
were
prepared.
PFCE
worked
as
carrier,
while
iron
oxide
(IONPs)
acted
nanozymes
catalase-like
activity
facilitate
generation.
enhance
plaque
targeting,
membranes
coated
onto
containing
and
IONPs.
5
tertiary
amine
was
doped
into
for
lysosomal
escape.
Our
results
demonstrated
that
FMMON@PL
specifically
macrophages
plaques.
significantly
reduced
HIF-1α
expression,
ameliorated
oxidative
stress,
inhibited
foam
cell
formation,
M1
macrophage
polarization.
In
conclusion,
successfully
achieved
within
plaques
progression,
demonstrating
feasibility
alleviation
treatment
Language: Английский