Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 74, P. 107799 - 107799
Published: April 29, 2025
Language: Английский
Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 74, P. 107799 - 107799
Published: April 29, 2025
Language: Английский
Chemical Science, Journal Year: 2023, Volume and Issue: 14(16), P. 4230 - 4247
Published: Jan. 1, 2023
This review explores the benefits of flow chemistry and dispels notion that it is a mysterious “black box”, demonstrating how can push boundaries organic synthesis through understanding its governing principles.
Language: Английский
Citations
199Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(2), P. 338 - 366
Published: Jan. 18, 2024
This review summarizes examples of organic electrosynthesis from the peer-reviewed literature 2000 to 2023 that have been conducted on scales 20 g or above. A significant portion these were a ≤100 scale, while detailed reports kilogram-scale remain scarce in pharmaceutical industry. In addition chemical transformation, this also highlights type reactor used and projected productivity metric as ways compare different reports. The selected scale-ups described herein illustrate remaining challenges currently preventing routine use large-scale
Language: Английский
Citations
44Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
3Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(15)
Published: Feb. 4, 2023
Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine-tuning of API performance. Moreover, deuterium labeling frequently carried out to study organic and bioorganic reaction mechanisms facilitate complex target synthesis. As such, methods highly selective molecules are desirable. Herein, we present an electrochemical method the deuterodehalogenation benzylic halides via a radical-polar crossover mechanism, using inexpensive oxide (D
Language: Английский
Citations
43Process Safety and Environmental Protection, Journal Year: 2023, Volume and Issue: 192, P. 622 - 637
Published: March 3, 2023
Language: Английский
Citations
28Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21960 - 21967
Published: July 23, 2024
Oxygen-atom transfer reactions are a prominent class of synthetic redox that often use high-energy oxygen-atom donor reagents. Electrochemical methods can bypass these reagents by using water as the source oxygen atoms through pathways involving direct or indirect (mediated) electrolysis. Here, manganese porphyrins and related mediators shown to be effective molecular electrocatalysts for selective oxidation thioethers sulfoxides, without overoxidation sulfone. The proceed proton-coupled Mn
Language: Английский
Citations
15Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(5), P. 1964 - 1970
Published: March 13, 2024
Although continuous flow synthesis using microtubing reactors has provided a wealth of opportunities for homogeneous photochemical and proven particularly beneficial in scaling up processes, employing technology to scale heterogeneous photoreactions is challenging due the issues including handling solids, poor light penetration, commonly lengthy reaction time. Here we present solution these by changing mode high-speed circulation mode. The high rate set reactor overcomes solid sedimentation prevent clogging improve mixing efficiency. We successfully conducted 100 g-scale C–N C–S cross-couplings photocatalyst nickel catalyst that significantly outperformed conventional batch reactors. was recycled reused 10 times achieve kilogram-scale without obvious deactivation. Semicontinuous production achieved via automated feeding collection, photopromoted gas/liquid/solid three-phase trifluoromethylation employed. A amount starting material transformed, resulting 43.2% yield trifluridine. Our study suggests with speed will become crucial tool synthetic chemist's toolbox because its simple infrastructure, ease operation automation, significant efficiency improvement compared reactors, scalability, improved safety, tolerance solids.
Language: Английский
Citations
10Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
A scalable electrochemical process to synthesize iminophosphorane ligands is reported. The application of these iminophosphoranes was recently reported in Ni-catalyzed cross-electrophile and C–N cross-couplings. use parallel plate flow reactors enables the synthesis on a multigram scale, with selected examples up 0.6 kg scale. Direct crystallization from end reaction mixture for provides facile isolation processes. This article also details improvements our capabilities across scales, including addressing material compatibility issues, increasing accessible range rates, integration analytical technology tools.
Language: Английский
Citations
2Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 27(11), P. 2072 - 2081
Published: Oct. 11, 2023
Technology for the rapid scale-up of synthetic organic electrochemistry from milligrams to multigrams or multi-100 g quantities is highly desirable. Traditional parallel plate flow electrolysis cells can produce large material, but transfer batch this technology requires reoptimization reaction conditions and fully homogeneous mixtures. Moreover, single-pass processing often difficult accomplish due gas generation low rates typically used in continuous mode. Herein we present a novel reactor design, based on rotating cylinder electrode concept, that enables seamless scale up small experimentation gram even multikilogram per day quantities. The device operate mode, it able easily process slurries without clogging system fouling electrodes. Continuous operation also demonstrated using three reactors series act as stirred electrochemical cascade, providing kilogram productivities single pass.
Language: Английский
Citations
21Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(18)
Published: Jan. 3, 2023
Alternating current (AC) electrolysis is receiving increased interest as a versatile tool for mild and selective electrochemical transformations. This work demonstrates that AC can enable the concept of stirring-free reactor where periodic switch electrode polarity, inherent to AC, provides uniform across whole volume reactor. Such design implies straightforward approach scaling up electrosynthesis. was demonstrated on range transformations performed in three different RVC-packed reactors 50-mmol scale. Redox-neutral, oxidative, reductive processes were successfully implemented using suggested applicable frequency ranges further investigated types reactions. The advantages AC-enabled - such absence stirring maximized surface area electrodes provide possibility its universal application both small-scale screening experimentation large-scale preparative electrosynthesis without significant optimization needed between.
Language: Английский
Citations
20