ChemSusChem,
Journal Year:
2024,
Volume and Issue:
17(10)
Published: Jan. 19, 2024
Abstract
Molecular
switches,
especially
azobenzenes,
are
used
in
numerous
applications,
such
as
molecular
solar
thermal
storage
(MOST)
systems
and
photopharmacology.
The
Baeyer‐Mills
reaction
of
anilines
nitrosobenzenes
has
been
established
an
efficient
synthetic
method
for
non‐symmetric
azobenzenes.
However,
not
stable,
depending
on
their
substitution
pattern
pose
a
health
risk.
An
in‐situ
oxidation
with
Oxone®
was
optimized
under
continuous
flow
conditions
avoiding
isolation
contact.
generated
nitrosobenzene
derivatives
were
subjected
to
telescoped
flow.
That
way
azobenzenes
broad
substituent
spectrum
made
accessible.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(16), P. 9633 - 9732
Published: Aug. 13, 2024
Self-driving
laboratories
(SDLs)
promise
an
accelerated
application
of
the
scientific
method.
Through
automation
experimental
workflows,
along
with
autonomous
planning,
SDLs
hold
potential
to
greatly
accelerate
research
in
chemistry
and
materials
discovery.
This
review
provides
in-depth
analysis
state-of-the-art
SDL
technology,
its
applications
across
various
disciplines,
implications
for
industry.
additionally
overview
enabling
technologies
SDLs,
including
their
hardware,
software,
integration
laboratory
infrastructure.
Most
importantly,
this
explores
diverse
range
domains
where
have
made
significant
contributions,
from
drug
discovery
science
genomics
chemistry.
We
provide
a
comprehensive
existing
real-world
examples
different
levels
automation,
challenges
limitations
associated
each
domain.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(19)
Published: March 18, 2024
Abstract
Unnatural
amino
acids,
and
their
synthesis
by
the
late‐stage
functionalization
(LSF)
of
peptides,
play
a
crucial
role
in
areas
such
as
drug
design
discovery.
Historically,
LSF
biomolecules
has
predominantly
utilized
traditional
synthetic
methodologies
that
exploit
nucleophilic
residues,
cysteine,
lysine
or
tyrosine.
Herein,
we
present
photocatalytic
hydroarylation
process
targeting
electrophilic
residue
dehydroalanine
(Dha).
This
possesses
an
α
,
β
‐unsaturated
moiety
can
be
combined
with
various
arylthianthrenium
salts,
both
batch
flow
reactors.
Notably,
setup
proved
instrumental
for
efficient
scale‐up,
paving
way
unnatural
acids
peptides
substantial
quantities.
Our
approach,
being
inherently
mild,
permits
diversification
even
when
they
contain
sensitive
functional
groups.
The
readily
available
salts
facilitate
seamless
integration
Dha‐containing
wide
range
arenes,
blueprints,
natural
products,
culminating
creation
unconventional
phenylalanine
derivatives.
synergistic
effect
high
group
tolerance
modular
characteristic
aryl
electrophile
enables
peptide
conjugation
ligation
conditions.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(13), P. 4618 - 4630
Published: Jan. 1, 2024
This
article
defines
the
role
that
continuous
flow
chemistry
can
have
in
new
reaction
discovery,
thereby
creating
molecular
assembly
opportunities
beyond
our
current
capabilities.
Most
notably
focus
is
based
upon
photochemical,
electrochemical
and
temperature
sensitive
processes
where
methods
machine
assisted
processing
significant
impact
on
chemical
reactivity
patterns.
These
platforms
are
ideally
placed
to
exploit
future
innovation
data
acquisition,
feed-back
control
through
artificial
intelligence
(AI)
learning
(ML)
techniques.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(5), P. 1327 - 1354
Published: March 14, 2024
The
effective
handling
of
solids
in
a
continuous
flow
process
is
one
the
biggest
perceived
challenges
remaining
for
modern
chemistry.
This
Review
aims
to
consider
some
processes
chemistries
involving
which
have
been
successfully
implemented.
Learnings
from
design
these
systems,
and
identification
common
blockers,
will
guide
generalized,
strategic
approach
drive
efficiency
future
batch-to-flow
development
challenging,
heterogeneous
systems.
Assorted
techniques
managing
continuous-flow
synthesis
be
presented
herein
through
series
case
studies,
broken
down
into
several
key
categories;
solubility
considerations,
setup
components
modularity,
applications
ultrasonication,
reactor
type
Grignard
reactions.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5597 - 5601
Published: April 19, 2024
A
traceless
site-selective
conjugation
method,
"AJICAP-M",
was
developed
for
native
antibodies
at
sites
using
Fc-affinity
peptides,
focusing
on
Lys248
or
Lys288.
It
produces
antibody–drug
conjugates
(ADCs)
with
consistent
drug-to-antibody
ratios,
enhanced
stability,
and
simplified
manufacturing.
Comparative
in
vivo
assessment
demonstrated
AJICAP-M's
superior
stability
over
traditional
ADCs.
This
technology
has
been
successfully
applied
to
continuous-flow
manufacturing,
marking
the
first
achievement
ADC
production.
manuscript
outlines
methodology
its
effectiveness
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(10)
Published: Jan. 10, 2024
A
subtle
combination
of
fundamental
and
applied
organic
chemistry
toward
process
intensification
is
demonstrated
for
the
large-scale
production
bio-based
glycerol
carbonate
under
flow
conditions.
The
direct
carbonation
glycidol
with
CO
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(65), P. 8497 - 8515
Published: Jan. 1, 2024
Continuous
flow
synthesis
offers
a
powerful
approach
for
MOF
&
composite
creation.
This
review
explores
its
recent
advancements,
advantages
over
batch
methods,
impact
on
properties.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(24), P. 3226 - 3239
Published: Jan. 1, 2024
This
feature
article
presents
an
overview
of
continuous
flow
chemistry,
including
photoflow
and
electroflow
technologies
in
the
preparation
active
pharmaceutical
ingredients
(APIs)
fine
chemical
intermediates.
