Molecules,
Journal Year:
2020,
Volume and Issue:
25(7), P. 1645 - 1645
Published: April 3, 2020
Nucleic
acid
derivatives
are
imperative
biomolecules
and
involved
in
life
governing
processes.
The
chemical
modification
of
nucleic
is
a
fascinating
area
for
researchers
due
to
the
potential
activity
exhibited
as
antiviral
antitumor
agents.
In
addition,
these
molecules
also
interest
toward
conducting
useful
biochemical,
pharmaceutical,
mutagenic
study.
For
accessing
such
synthetically
structures
features,
transition-metal
catalyzed
processes
have
been
proven
over
years
be
an
excellent
tool
carrying
out
various
transformations
with
ease
under
mild
reaction
conditions.
Amidst
available
nucleoside
modification,
Pd-catalyzed
cross-coupling
reactions
perhaps
most
efficient,
successful,
broadly
applicable
both
academia
industry.
C–C
C–heteroatom
bond
forming
widely
used
heterocyclic
moiety
nucleosides,
although
single
catalyst
system
that
could
address
all
different
requirements
modifications
isvery
rare
or
non-existent.
With
this
mind,
we
present
herein
review
showcasing
recent
developments
improvements
from
our
research
groups
development
strategies
including
drug
synthesis
using
efficient
nucleosides
other
heterocycles.
highlights
improvement
conditions
yield
bio-active
commercial
drugs
possessing
structural
core.
Scale
ups
wherever
performed
(up
100
g)
importance
disclosed.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4266 - 4278
Published: Feb. 8, 2023
Savie
is
a
biodegradable
surfactant
derived
from
vitamin
E
and
polysarcosine
(PSar)
developed
for
use
in
organic
synthesis
recyclable
water.
This
includes
homogeneous
catalysis
(including
examples
employing
only
ppm
levels
of
catalyst),
heterogeneous
catalysis,
biocatalytic
transformations,
including
multistep
chemoenzymatic
sequence.
Use
frequently
leads
to
significantly
higher
yields
than
do
conventional
surfactants,
while
obviating
the
need
waste-generating
solvents.
Catalysis Science & Technology,
Journal Year:
2020,
Volume and Issue:
10(14), P. 4492 - 4502
Published: Jan. 1, 2020
Recent
development
of
new
designer
surfactants
further
spurs
the
micellar
catalysis
in
water
for
chemical
transformations
and
catalysis,
providing
reliable
alternatives
to
employment
organic
solvents.
Journal of Agricultural and Food Chemistry,
Journal Year:
2021,
Volume and Issue:
69(23), P. 6423 - 6430
Published: June 4, 2021
Nicotinic
acid,
also
known
as
niacin,
is
a
natural
product,
which
widely
found
in
plants
and
animals.
To
discover
novel
natural-product-based
herbicides,
series
of
N-(arylmethoxy)-2-chloronicotinamides
were
designed
synthesized.
Some
the
new
exhibited
excellent
herbicidal
activity
against
Agrostis
stolonifera
(bentgrass)
at
100
μM.
Compound
5f
(2-chloro-N-((3,4-dichlorobenzyl)oxy)nicotinamide)
possessed
Lemna
paucicostata
(duckweed),
with
an
IC50
value
7.8
μM,
whereas
commercial
herbicides
clomazone
propanil
had
values
125
2
respectively.
The
structure–activity
relationships
reported
this
paper
could
be
used
for
development
monocotyledonous
weeds.
ACS Catalysis,
Journal Year:
2020,
Volume and Issue:
10(12), P. 6816 - 6821
Published: April 22, 2020
A
scalable
synthetic
method
is
described
for
both
the
preparation
of
ultrasmall
palladium
nanoparticles
and
their
subsequent
use
in
catalyzing
an
α-arylation
reaction
nitriles
aqueous
micelles.
This
involves
intermediacy
carbanions
or
keteniminates,
which
are
presumably
stabilized
by
micellar
environment
rather
than
being
quenched
with
water.
These
Pd
thoroughly
characterized.
Mechanistic
studies
using
31P
NMR
spectroscopy
revealed
binding
phosphine
ligand
surface
control
experiment
confirmed
zero-oxidation
state
palladium.
The
scope
transformation
demonstrated
over
35
examples,
including
one
at
50
g
scale.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(16), P. 6324 - 6329
Published: Aug. 3, 2020
Condensation
in
recyclable
water
between
aldehydes
or
ketones
and
amines
occurs
smoothly
within
the
hydrophobic
cores
of
nanomicelles,
resulting
imine
formation
that
is
subject
to
subsequent
reduction
leading,
overall,
reductive
amination.
This
micellar
technology
enables
synthesis
several
types
pharmaceuticals,
a
new
procedure
relies
on
only
2000
ppm
(0.20
mol
%)
palladium
from
commercially
available
Pd/C.
A
broad
range
substrates
can
be
used
under
mild
conditions,
leading
high
chemical
yields
desired
secondary
tertiary
amines.
