The influential IPr: 25 years after its discovery

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

25 Years after the discovery of most influential NHC ligand, we revisit and highlight studies involving IPr that have shaped field NHC-transition metal catalysis.

Language: Английский

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Bulky N-heterocyclic carbene Cu(I) complex as a catalyst for the synthesis of N-arylazoles under ambient conditions

Tetrahedron, Journal Year: 2025, Volume and Issue: 172, P. 134449 - 134449

Published: Jan. 5, 2025

Language: Английский

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Mechanistic Insights into Molecular Copper Hydride Catalysis: the Kinetic Stability of CuH Monomers toward Aggregation is a Critical Parameter for Catalyst Performance

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

The activity of molecular copper hydride (CuH) complexes toward the selective insertion unsaturated hydrocarbons under mild conditions has contributed significantly to versatile methodologies for upgrading these feedstocks. However, catalysts are particularly susceptible deleterious aggregation, leading depletion active CuH species. Little is known about mechanisms how it influences overall catalyst performance, and can be controlled. We address challenges with mechanistic studies on a model reaction unactivated alkene hydroboration catalyzed by (IPr*CPh3)CuH (LCuH). report comprehensive investigation this system, identifying an aggregation pathway that continuously depletes catalytically LCuH form inactive clusters during turnover. Deactivation controlled primarily competition between kinetics initial dimerization step into LCuH. therefore propose understanding performance must account step, revising previously explored thermodynamic where concentration species equilibria established monomers. With series (NHC)CuH congeners (NHC = N-heterocyclic carbene), we demonstrate ostensibly minor structural modifications ligand peripheries drastically affect kinetics, while maintaining reactivity on-cycle insertion. employed computational approach based dynamics simulations provide in-depth specific substantially increase kinetic stability monomeric catalysts. Our combined experimental suggest strategies rational design broadly applied systems deactivation via pathways.

Language: Английский

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Group XI Complexes Supported by Chiral N-Heterocyclic Ligands Built on the Imidazo[1,5-a]pyridin-3-ylidene Skeleton: Synthesis, Characterization, and Evaluation in Selective Catalysis

Organometallics, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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