The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 13288 - 13299
Published: Sept. 27, 2022
A
visible-light-promoted
difluoromethylation/cyclization
of
2-vinyloxy
arylalkynes
was
developed,
providing
a
variety
bis(difluoromethyl)-substituted
benzofurans
in
moderate
to
good
yields.
plausible
mechanism
involving
difluoromethyl
radical
cascade
cyclization
and
solvent-promoted
ionic
addition
proposed.
This
protocol
has
the
advantages
having
mild
reaction
conditions,
simple
operation,
functional
group
tolerance.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(13), P. 3598 - 3623
Published: Jan. 1, 2022
The
combination
of
visible
light
photoredox
catalysis
with
direct
difluoromethylation
has
allowed
the
synthesis
a
large
choice
CF
2
H-containing
value-added
molecules
under
very
mild
reaction
conditions.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(6), P. 1085 - 1090
Published: Feb. 10, 2022
Abstract
A
radical
di‐
and
trichloromethylation/cyclization
of
unactivated
alkenes
was
developed
with
commercially
available
dichloromethane
chloroform
as
di‐and
trichloromethyl
sources
under
metal‐free
conditions.
Variously
substituted
trichloromethylated
pyrrolo‐
piperidino‐quinazolinones
were
obtained
in
47–94%
yields.
Additionally,
dibromomethylation/cyclization
also
achieved
standard
conditions
when
CH
2
Br
utilized.
Moreover,
the
dichloromethylated
product
can
be
transformed
into
1′
H
‐spiro[cyclopropane‐1,3′‐pyrrolo[2,1‐
b
]quinazolin]‐9′(2′
)‐one
after
treating
by
KOH.
magnified
image
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(15), P. 10146 - 10157
Published: July 13, 2022
A
mild
and
facile
photo-induced
cascade
radical
addition/cyclization
of
unactivated
alkenes
has
been
reported,
through
which
a
variety
biologically
valuable
phosphine-containing
quinazolinones
could
be
obtained
in
moderate
to
good
yields.
The
protocol
was
characterized
by
conditions,
broad
substrate
scope,
high
atomic
economy.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(22), P. 6290 - 6294
Published: Jan. 1, 2022
The
synthesis
of
sulfonamidylated
polycyclic
quinazolinones
was
developed
via
visible-light-induced
radical
sulfonamidation/cyclization
unactivated
alkenes
using
4CzIPN
as
the
photocatalyst.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(19), P. 2767 - 2770
Published: Jan. 1, 2023
Radical-mediated
photoredox
hydroarylation
reaction
of
unactivated
alkenes
using
thiosulfonate
compounds
as
key
radical
precursors
to
synthesize
pyridyquinazolinone
and
pyrroloquinazolinone
derivatives
is
described.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(10), P. 1683 - 1688
Published: March 8, 2023
A
visible-light-induced
hydrocyclization
of
unactivated
alkenes
was
developed
using
3CzClIPN
as
the
photocatalyst
to
generate
substituted
α-methyldeoxyvasicinones
and
α-methylmackinazolinones
in
moderate
good
yields.
An
intermolecular
hydrogen
atom
transfer
with
THF
source
involved.
Mechanism
studies
indicated
that
intramolecular
addition
situ
formed
aminal
radical
alkene
generated
polycyclic
quinazolinone.
