The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 13288 - 13299
Published: Sept. 27, 2022
A
visible-light-promoted
difluoromethylation/cyclization
of
2-vinyloxy
arylalkynes
was
developed,
providing
a
variety
bis(difluoromethyl)-substituted
benzofurans
in
moderate
to
good
yields.
plausible
mechanism
involving
difluoromethyl
radical
cascade
cyclization
and
solvent-promoted
ionic
addition
proposed.
This
protocol
has
the
advantages
having
mild
reaction
conditions,
simple
operation,
functional
group
tolerance.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(18), P. 2556 - 2559
Published: Jan. 1, 2024
3-(2-Isocyanophenyl)quinazolin-4(3
H
)-ones
were
designed
and
synthesized
as
new
building
units
for
the
construction
of
novel
quinoxalino[2,1-
b
]quinazolinones
under
mild,
photocatalytic
metal-free
conditions.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(31)
Published: June 5, 2024
Abstract
During
the
past
decade,
radical
difluoromethylation
has
emerged
as
a
powerful
and
versatile
tool
for
incorporation
of
difluoromethyl
into
various
organic
compounds.
These
reactions
feature
mild
reaction
conditions,
very
good
functional
group
compatibilities,
quite
broad
substrate
scopes,
thus
having
drawn
much
attention
got
rapid
developments.
A
diverse
range
precursors
have
been
developed
series
reactions.
This
review
summarizes
discusses
advance
in
reactions,
which
are
organized
according
to
protocols
generating
radical.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 13288 - 13299
Published: Sept. 27, 2022
A
visible-light-promoted
difluoromethylation/cyclization
of
2-vinyloxy
arylalkynes
was
developed,
providing
a
variety
bis(difluoromethyl)-substituted
benzofurans
in
moderate
to
good
yields.
plausible
mechanism
involving
difluoromethyl
radical
cascade
cyclization
and
solvent-promoted
ionic
addition
proposed.
This
protocol
has
the
advantages
having
mild
reaction
conditions,
simple
operation,
functional
group
tolerance.
