Synlett,
Journal Year:
2022,
Volume and Issue:
34(05), P. 465 - 470
Published: July 25, 2022
Abstract
A
dearomative
[3+2]-cycloaddition
reaction
of
oxindole-embedded
azaoxyallyl
cations
with
indoles
at
the
C3
position
has
been
developed.
The
use
this
new
class
cation
species
in
permits
access
to
more-elaborate
hexahydropyrrolo[2,3-b]indole
moieties
that
contain
a
spiro-oxindole
ring.
transformation
displays
broad
substrate
scope
and
good
regio-
stereoselectivity
for
cycloaddition
step.
Several
observations
suggested
can
display
different
reactivity
pattern
from
those
commonly
employed
systems.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(7), P. 2572 - 2576
Published: Jan. 1, 2023
We
disclose
a
feasible
strategy
for
the
electrochemical
dehydrogenative
coupling
of
CS
2
and
amines
with
β-ketoesters,
which
leads
to
dithiocarbamate
intermediates
in
presence
bases.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(11), P. 1509 - 1512
Published: Jan. 1, 2023
An
efficient
catalyst-
and
additive-free
facile
access
to
rhodanine
S
-alkyl
dithiocarbamate
derivatives
via
multi-component
reaction
of
amines,
CS
2
α-ester
sulfoxonium
ylides
in
methanol
has
been
described.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
This
study
proposes
a
green
and
efficient
atom-
step-economical
method
for
converting
hazardous
CS2
to
dithiocarbamate
derivatives
under
visible
light
irradiation
catalyst-free
conditions.
By
the
construction
of
novel
C-S
C-N
bonds,
series
β-dicarbonyl
compounds
amines
are
incorporated
into
products.
Under
light,
amine
first
form
bis(dialkylaminethiocarbonyl)disulfides,
which
then
react
with
K2CO3-activated
electron
donor-acceptor
(EDA)
complexes
subsequently
generate
target
confirms
time
that
bis(dialkylaminethiocarbonyl)disulfides
can
act
as
acceptors
an
EDA
complex
compounds,
coupled
product
light.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
1,2,4-Thiadiazoles,
a
significant
class
of
heterocyclic
compounds,
are
widely
found
in
biologically
active
molecules.
Herein,
we
report
green
electrochemical
three-component
reaction
amines,
amidines,
and
CS2
for
the
effective
synthesis
3,5-disubstituted-1,2,4-thiadiazoles
under
metal-
oxidant-free
conditions.
Both
aliphatic
aryl
amines
well-tolerated
at
room
temperature
simple
undivided
cell.
A
series
1,2,4-thiadiazoles
prepared
with
excellent
functional
groups.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(47)
Published: Oct. 10, 2022
Abstract
Aza‐oxyallyl
cations,
as
proposed
by
Sheehan
in
the
1960s
have
garnered
significant
attention
among
synthetic
organic
community,
owing
to
their
diverse
reactivity
profile
for
constructing
N‐scaffolds
of
biological
interest.
During
its
initial
growth,
aza‐oxyallyl
cations
were
used
effectively
a
3‐unit
synthon
1,3
dipoles
create
N‐heterocycles
via
cycloaddition
reactions,
wherein
cation
served
electrophilic
counterpart.
Recently,
new
variations
been
reported,
including
usage
1,4
dipole
domino
and
unique
alkylating
ability
heteroatoms.
This
review
article
provides
an
update
recent
developments
this
area
prevailing
mechanistic
insight.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
42(8), P. 846 - 852
Published: Dec. 20, 2023
Comprehensive
Summary
A
convenient
approach
for
the
construction
of
2‐aminobenzothiazoles
via
I
2
‐catalyzed
tandem
cyclization
reaction
amines
and
carbon
disulfide
has
been
developed.
The
present
starts
from
simple
readily
available
starting
materials,
affording
a
series
in
up
to
89%
yields
under
metal‐free
conditions.
In
this
work,
C—H/N—H
functionalization
was
achieved
multiple
C‐hetero
bonds
were
successfully
constructed
one
pot.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(54), P. 7538 - 7541
Published: Jan. 1, 2022
Herein,
a
transition
metal-free
approach
for
access
to
3,3'-disubstituted
peroxyoxindole
is
disclosed,
which
harnesses
transient
azaoxyallyl
cation.
This
strategy
also
applicable
the
synthesis
of
structurally
diverse
α-peroxycarboxylic
acid
surrogates.
The
method
exhibits
good
functional
group
tolerance
and
suitable
generating
library
peroxy-containing
compounds.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(37), P. 7535 - 7540
Published: Jan. 1, 2023
A
concise
approach
to
the
construction
of
2-pyrrolin-5-one
scaffold
was
developed
via
a
one-pot
reaction
with
formal
[3
+
2]
annulation/elimination
between
β-keto
nitrile/β-keto
ester
and
unsubstituted
α-halohydroxamates.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(10), P. 7109 - 7114
Published: Feb. 6, 2024
We
present
a
streamlined,
metal-free,
one-pot
domino
approach
to
efficiently
synthesize
oxazolidinethione
derivatives
containing
substituted
quaternary
amino
acids.
This
method
employs
α-amino
esters,
aldehydes,
and
CS2
under
mild
conditions,
constructing
three
new
bonds
(C–N,
C–C,
C–O)
produce
compounds
featuring
center
beta-hydroxy
derivative
in
high
yields.
scalable
protocol
enables
the
creation
of
libraries
biologically
significant,
intricate
acid
using
esters
aldehydes.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Alcohols
are
the
most
commercially
abundant,
synthetically
versatile
and
operationally
convenient
functional
groups
in
organic
chemistry.
Therefore,
a
strategy
that
utilizes
hydroxy-containing
compounds
to
develop
novel
bond
disconnection
formation
process
would
achieve
molecular
diversity.
Herein,
deconstructive
for
generation
of
quinoxalin-2(1H)-one
derivatives
has
been
developed
from
alcohol
precursors
via
oxy-radical-induced
β-fragmentation.
Additionally,
1,5-HAT
deoxygenation
by
P(III)
along
with
oxy-radical
were
demonstrated
as
alternative
pathways
this
transformation.
Furthermore,
deep-seated
reorganization
few
terpenes
carbon
framework,
unique
activity
inhibition
against
growth
pathogenic
fungi
was
observed.
