Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization

Green Synthesis and Catalysis, Journal Year: 2023, Volume and Issue: 5(3), P. 195 - 199

Published: April 3, 2023

A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope with good functional group tolerance probably undergoes SET process, which initiated by catalytic amounts of quinone in combination 2.0 equiv. Cs2CO3.

Language: Английский

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Transition-metal-free tandem cyclization by radical NHC catalysis: Rapid access to indolo[2,1‑a]isoquinolines

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155319 - 155319

Published: Oct. 1, 2024

Language: Английский

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N-heterocyclic carbene switchable radical or benzyne meditated arylation of thiols using DMF/KOtBu

Synlett, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract A mild, metal, and photoredox-free direct arylation of alkyl aryl thiols with iodides using a DMF/KOt-Bu system has been developed. In the absence an N-heterocyclic carbene (NHC) additive, reaction proceeds via benzyne intermediate was suitable for substitution phenyl, while presence NHC or phenanthroline derivative improves regioselectivity substituted radical pathway. This protocol features inexpensive materials good substrate scope could be useful in thiols.

Language: Английский

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Singly and doubly oxidized carbenes and their applications in catalysis

Chem Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 101159 - 101159

Published: Nov. 1, 2024

Language: Английский

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