Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
The
preparation
of
functionalized
ketones
occupies
an
important
position
in
synthetic
organic
chemistry
because
are
ubiquitous
structural
motifs
a
broad
range
compounds
with
various
applications.
conversion
aldehydes
to
is
one
the
most
convenient
and
straightforward
routes,
which
has
been
extensively
studied
field
transition
metal
catalysis.
In
comparison,
transition-metal-free
remains
underdeveloped.
last
decade,
emergence
new
advances
upgraded
toolbox
for
ketone
synthesis
from
absence
metals.
this
review,
we
have
mainly
summarized
three
types
reactions
enabling
ketones,
emphasis
on
those
involving
main
group
element
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(7), P. 2112 - 2133
Published: Jan. 1, 2024
Organofluorine
compounds
are
of
high
value.
NHC-catalyzed
fluorination
and
fluoroalkylation
have
served
as
powerful
versatile
vehicles
for
accessing
the
related
organofluorines.
This
review
focuses
on
recent
developments
in
this
area.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(18), P. 4488 - 4515
Published: Jan. 1, 2023
This
review
highlights
the
recent
advances
in
radical
acylated
difunctionalization
of
unsaturated
carbon–carbon
bonds
and
focuses
on
mechanistic
insights
these
transformations.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(48)
Published: Oct. 11, 2023
Abstract
N
‐Heterocyclic
carbene
(NHC)
catalyzed
radical‐radical
reactions
have
been
proven
to
be
powerful
strategies
for
assembling
ketyl‐containing
compounds
via
single
electron
transfer
(SET)
pathway
under
either
thermal
conditions
or
photoredox
conditions.
In
this
context,
acylation
of
alkenes
radical
relay
NHC‐organocatalysis
has
also
opened
a
new
window
the
difunctionalization
construct
valuable
molecules
in
organic
synthesis.
review,
advances
and
progress
were
summarized
according
different
ways
generation
key
NHC‐bound
ketyl‐type
radicals.
Furthermore,
reaction
scopes,
limitations
mechanisms
discussed
based
on
types
catalytic
systems.
Conclusions
perspectives
put
forward
at
end.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(6), P. 1045 - 1049
Published: Feb. 8, 2023
We
herein
describe
a
straightforward
allylic
difluoromethylation
reaction
of
unactivated
alkenes.
Compared
to
cross-couplings
prefunctionalized
substrates
for
the
construction
CF2H
bonds,
this
employs
readily
available
alkenes
as
under
mild
conditions.
Difluoroacetic
acid
is
used
an
inexpensive
and
easy-to-handle
source
radical
visible
light
irradiation
with
PIDA.
The
copper
catalyst
plays
important
role
diverting
pathway
toward
opposed
previously
found
hydrodifluoromethylation.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(24), P. 6124 - 6130
Published: Jan. 1, 2023
We
herein
describe
a
three-component
radical
acylmonofluoromethylation
of
alkenes
by
cooperative
NHC/photoredox
catalysis
to
synthesize
various
monofluorinated
alkyl
aryl
ketones.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(11), P. 3089 - 3099
Published: Jan. 1, 2024
NHC
and
photocatalysis
dual-catalyzed
mono/difluoromethylative
acylation
of
1,3-enynes
was
realized,
providing
fluormethyl-substituted
allenyl
ketones.
SO
2
might
play
a
critical
role
in
achieving
high
reactivity
selectivity.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(20), P. 4351 - 4355
Published: May 10, 2024
We
report
a
novel
three-component
radical
acylfluoroalkylation
of
1,3-enynes
by
synergistic
N-heterocyclic
carbene
(NHC)/photoredox
catalysis
toward
various
fluorinated
allenic
aryl
ketones.
This
protocol
features
broad
substrate
scope
and
excellent
functional
group
tolerability,
with
examples
late-stage
modification
drug
molecules
natural
products.
Notably,
seven
different
fluoroalkyl
motifs
can
be
introduced
to
1,3-enynes,
further
demonstrating
the
robustness
generality
this
method.
The
generation
from
each
sulfinate
reagent
was
individually
supported
EPR
experiments.
