The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
As
a
significant
variant
of
the
Michael
reaction,
1,6‐addition
reaction
has
undergone
considerable
development
over
past
decade.
This
effective
strategy
enables
synthesis
variety
novel
and
potentially
bioactive
functional
molecules.
In
this
review,
we
summarize
recent
progress
in
NHC‐catalyzed
reactions,
highlighting
their
efficiency
rapid
complex
We
also
provide
our
perspectives
on
future
dynamic
highly
active
research
area.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(11), P. 8270 - 8293
Published: May 13, 2024
As
one
of
the
most
important
key
intermediates,
NHC-bound
acylazolium-based
ionic
transformations
have
been
intensively
explored
in
past
two
decades.
With
expeditious
development
NHC-catalyzed
radical
recent
years,
acylazolium
chemistry
has
reached
another
level,
with
number
relevant
publications
increasing
significantly.
However,
a
summary
focused
on
acylations
NHC-derived
acyl
azoliums
classified
according
to
mechanistic
difference
not
reported.
Such
detailed
classification
and
deep
analysis
provide
opportunities
for
better
understanding
history
trend
this
field.
In
review,
reactions
N-heterocyclic
carbene
(NHC)-derived
are
systematically
introduced.
The
achievements
challenges
within
area
also
summarized
discussed
at
end.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 25, 2025
Comprehensive
Summary
Vicinal
all‐carbon
quaternary
stereocenters
are
widely
present
in
natural
products
and
bioactive
molecules.
However,
the
construction
of
such
motif
one
step
from
readily
available
starting
materials
remains
a
significant
challenge.
Herein,
we
report
phosphine‐catalyzed
divergent
γ,γ‐
ε,γ‐umpolung
domino
addition
bisoxindoles
with
allenoates.
This
method
serves
as
practical
tool
for
concise
synthesis
series
bisoxindole
derivatives
bearing
sterically
hindered
vicinal
under
mild
reaction
conditions.
The
applicability
this
novel
was
demonstrated
gram‐scale
three
known
advanced
intermediates
total
syntheses
calycanthine,
chimonanthine
folicanthine.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(10), P. 2762 - 2767
Published: Jan. 1, 2024
A
P(NMe2)3-catalyzed
[4
+
2]
annulation
of
2-amino-β-nitrostyrenes
and
β′-acetoxy
allenoates
followed
by
a
Zn/AcOH-mediated
reduction–hydroamination–isomerization
has
been
developed.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(53), P. 6773 - 6776
Published: Jan. 1, 2024
A
novel
phosphine-mediated
α-umpolung/Wittig
olefination/cyclization
cascade
process
between
o
-aminobenzaldehydes
and
Morita–Baylis–Hillman
(MBH)
carbonates
has
been
ingeniously
developed
for
the
facile
synthesis
of
a
broad
range
2-vinylindolines.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(18), P. 2203 - 2210
Published: May 14, 2024
Comprehensive
Summary
Compared
to
well‐established
1,5‐HAT
of
N
‐centered
radicals,
the
synthetic
applications
1,2‐HAT
process
were
scarce
due
high
barrier
and
constrained
three‐membered
transition
state.
Here,
we
have
developed
a
novel
C(sp
3
)‐H
gem
‐difluoroallylation
via
base
assisted
formal
amidyl
radicals
with
reductive
quenching
cycle
photocatalyst.
This
transformation
enables
efficient
formation
α‐aminoalkyl
showcases
good
functional
group
tolerance.
Our
preliminary
mechanistic
experiments,
along
Density
Functional
Theory
(DFT)
calculations
demonstrate
feasibility
especially
when
by
base.
Furthermore,
our
method
also
succeeds
in
Giese
addition
electron‐deficient
alkenes
as
well
styrene.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(26)
Published: May 22, 2024
Abstract
Here
we
report
a
mild
protocol
for
benzylic
C−H
trifluoromethylthiolation
using
sodium
decatungstate
(NaDT)
as
the
photocatalyst.
Wherein,
photoactivated
DT
abstracted
hydrogen
atom
via
radical
process.
This
transformation
works
well
with
slight
excess
of
substrates
or
limiting
reagents
better
purification.
The
reaction
shows
conditions
and
good
functional
group
tolerance.
Moreover,
could
be
applied
to
gram‐scale
synthesis.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 7790 - 7794
Published: May 29, 2024
The
incorporation
of
difluoromethylene
groups
into
aza-heterocycles
represents
a
compelling
yet
underexplored
avenue
in
contemporary
chemical
research.
In
this
study,
we
unveil
hybrid
palladium-catalyzed
intramolecular
gem-difluoroalkylamination
conjugated
dienes,
providing
versatile
approach
to
the
synthesis
diverse
functionalized
pyrrolidines.
Noteworthy
features
include
mild
reaction
conditions
and
remarkable
tolerance
toward
various
functional
groups.
Additionally,
use
alkyl
iodides
as
electrophiles
facilitates
generation
corresponding
alkylamination
products.
Control
experiments
support
proposed
radical–polar
crossover
pathway,
offering
insights
underlying
processes
governing
transformation.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(71), P. 9483 - 9512
Published: Jan. 1, 2024
This
review
highlights
recent
advances
in
transition
metal
complexes
of
silylene,
showcasing
their
efficacy
hydroboration,
hydrosilylation,
hydrogenation,
hydrogen
isotope
exchange,
and
small
molecule
activation
chemistry.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 7, 2024
An
unexpected
phosphine-catalyzed
controllable
three-component
domino
reaction
involving
[1
+
2
2]
annulation
and
2]/[3
sequential
of
2-arylmethylidene
cyanoacetates/malononitriles
with
Morita-Baylis-Hillman
(MBH)
carbonates
has
been
developed.
A
broad
range
densely
functionalized
cyclopentanes
diquinanes
bearing
five
or
four
consecutive
stereogenic
centers,
including
two
all-carbon
quaternary
stereocenters,
were
smoothly
acquired
in
moderate
to
excellent
yields
under
mild
conditions
from
readily
available
materials.
Moreover,
this
divergent
transformation
enables
the
simultaneous
generation
three
new
C-C
bonds
one
carbocyclic
rings
only
step.
