Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(11), P. 3939 - 3939
Published: Jan. 1, 2023
Alkyl
aryl
ketones
are
a
class
of
valuable
compounds
in
chemistry
and
biology,
which
widely
used
the
pharmaceutical,
spice,
dye,
pesticide,
functional
materials,
organic
synthesis
industries.A
cobalt-catalyzed
oxyalkylation
reaction
olefin
with
tert-butyl
hydroperoxide
(TBHP)
cyclic
ethers
was
developed.Various
substrates
electron-withdrawing
or
electron-donating
groups
were
tolerated
this
protocol
to
provide
α-alkyl
substituted
acetophenones
moderate
yields.The
present
features
broad
substrate
scope,
flexibility,
allowing
rapid
assembly
series
value-added
acetophenone
derivatives
under
mild
conditions
good
efficacy.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(14), P. 2310 - 2331
Published: June 24, 2023
Abstract
Alkenes
are
valuable
feedstocks
in
organic
synthesis.
Selenium
or
sulfur‐containing
coumpounds
with
a
neighboring
functional
group
can
be
easily
prepared
by
direct
difunctionalization
of
alkenes
via
three‐component
reactions.
It
will
reduce
the
number
steps
and
waste
generation,
form
complicated
molecules
from
simple
starting
materials.
Herein,
recent
developments
(2013–2022)
have
been
summarized
two
categories:
(1)
selenylation
seleniranium
intermediates
Se‐centered
radicals;
(2)
thiolation
more
diverse
mechanisms
products
Reactions
electron‐rich
arenes,
alcohols,
water,
acids,
NaN
3
,
amines,
KSCN,
sulfamides,
TMSNCS,
TMSN
Et
N
⋅
3HF,
SOCl
2
HCl,
NFSI,
t
BuONO,
pyridinium
salts,
BuOOH,
ArN
BF
4
CO
CO,
O
CF
SO
Cl,
R
P(O)−H,
(RO)
P(O)SH,
P(O)OH
et
al
discussed.
We
hope
this
review
do
help
for
future
research
area.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(25)
Published: April 22, 2023
In
this
study,
we
designed
a
bilateral
disulfurating
reagent
via
S-S
motif
"snip
and
stitch"
processes,
allowing
diverse
functional
groups
to
be
bridged
bonds.
The
is
readily
synthesized
in
high
yield
using
one-step
reaction
from
easily
available
starting
materials
air-stable.
With
reagent,
electrophiles
including
inactivated
alkyl
Cl/Br/I/OMs
benzyl
chloride
were
sequentially
installed
on
either
side
of
the
motif.
Natural
products,
agrochemicals,
pharmaceuticals
can
successively
cross-linked
with
Notably,
used
cyclic
disulfide
synthesis.
At
last,
some
desired
products
work
showed
good
antibacterial
activities,
which
could
employed
as
novel
candidates
control
plant
pathogenic
bacteria.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Molecules
containing
fluoroalkyl
and
arylthio
groups
play
a
pivotal
role
in
pharmaceutical
agrochemical
development.
The
simultaneous
introduction
of
these
functional
through
the
1,2-difunctionalization
alkenes
is
an
efficient
strategy.
Fluoroalkyl
phenyl
sulfones
serve
as
accessible
radical
precursors;
however,
their
tendency
to
interact
with
thiophenol
via
electron
donor–acceptor
interaction
mechanism
can
impede
desired
transformation.
Through
meticulous
selection
solvent
base,
we
successfully
utilized
copper
catalysis
facilitate
alkene-involved
three-component
reaction.
Our
work
unveils
photoredox
copper-catalyzed
fluoroalkylation–thiolation
using
various
(such
perfluoroethyl,
tetrafluoroethyl,
trifluoromethyl,
difluoromethyl,
difluoroalkyl,
difluorobenzyl).
efficacy
this
approach
exemplified
by
synthesis
Kengreal
derivatives.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(100), P. 13915 - 13918
Published: Jan. 1, 2022
Herein
we
reported
the
use
of
Earth-abundant
iron
as
catalytic
metal
in
presence
Mn
to
induce
difluorobromoacetates
form
carbon
radicals,
which
reacted
with
trifluoromethyl
olefins
followed
by
β-F
elimination
generate
corresponding
gem-difluoroolefins.
The
cross-electrophile
coupling
displayed
excellent
functional
group
tolerance
and
broad
substrate
scope
under
mild
reductive
conditions,
affording
a
large
number
polyfluorinated
compounds,
could
be
further
transformed
other
valuable
molecules.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(10)
Published: April 8, 2023
Abstract
A
novel
and
facile
method
for
the
synthesis
of
N
‐β‐CF
3
‐substituted
2‐pyridones
via
hydroamination
α‐(trifluoromethyl)styrenes
with
was
described.
The
reaction
proceeded
smoothly
at
room
temperature,
affording
a
variety
‐(β‐trifluoromethyl‐β‐arylethyl)pyridin‐2(1
H
)‐ones
in
moderate
to
good
yields
excellent
‐regioselectivity.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
23(9)
Published: June 12, 2023
Abstract
The
trifluoromethyl
group
is
a
powerful
structural
motif
in
drugs
and
polymers;
thus,
developing
trifluoromethylation
reactions
an
important
area
of
research
organic
chemistry.
Over
the
past
few
decades,
significant
progress
has
been
made
new
methods
for
molecules,
ranging
from
nucleophilic
electrophilic
approaches
to
transition‐metal
catalysis,
photocatalysis,
electrolytic
reactions.
While
these
were
initially
developed
batch
systems,
more
recent
microflow
versions
are
highly
attractive
industrial
applications
owing
their
scalability,
safety,
time
efficiency.
In
this
review,
we
discuss
current
state
trifluoromethylation.
Approaches
based
on
different
reagents
described,
including
continuous
flow,
flow
photochemical,
microfluidic
electrochemical
reactions,
large‐scale
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(39)
Published: Aug. 19, 2023
Abstract
Sulfonyl
chlorides
are
a
class
of
cheap
and
readily
available
basic
chemicals,
which
have
routinely
served
as
electrophilic
reagents
in
their
chemical
transformations.
Herein,
we
disclose
novel
PPh
3
‐mediated
nucleophilic
sulfonation
method
sulfonyl
with
arynes.
Different
from
the
classical
P(III)‐mediated
reductive
deoxygenation
reaction
chlorides,
valence
state
sulfur
atom
has
not
been
changed.
This
protocol
exhibits
broad
functional
group
tolerance
provides
direct
approach
to
variety
aryl
alkyl
sulfones.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
19(20)
Published: July 23, 2024
Abstract
A
very
simple
and
atom‐economical
method
for
the
synthesis
of
vicinal
trifluoromethyl
thioethers
via
DBN‐catalyzed
hydrothiolation
α‐(trifluoromethyl)styrenes
with
thiols
was
reported.
The
reaction
proceeded
smoothly
under
mild
conditions
provided
β‐CF
3
‐thioethers
in
moderate
to
good
yields
an
anti‐Markovnikov
manner.
Furthermore,
this
features
several
remarkable
advantages,
such
as
use
a
catalytic
amount
DBN,
broad
substrate
scope,
excellent
functional
group
compatibility,
easy
scalability.
ChemSusChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
The
integration
of
multicomponent
reactions
(MCRs),
which
offer
a
rapid
and
efficient
approach
to
synthesize
complex
molecular
scaffolds,
with
continuous
flow
platforms
is
an
increasingly
recognized
strategy
in
green
synthesis.
This
association
enables
precise
control
over
reaction
parameters,
including
improved
kinetics
selectivity,
reduced
times,
enhanced
yields
scalabilities,
while
aligning
sustainable
chemistry
principles
through
resource
utilization,
minimized
waste,
environmental
impact.
review
presents
critical
analysis
recent
studies
covering
the
MCR-continuous
association,
focus
on
achieving
greener
more
synthesis
practices.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(22), P. 3045 - 3049
Published: July 15, 2023
Comprehensive
Summary
A
deuterated
methylthiolating
reagent
with
a
broad
spectrum,
designated
as
DMTP,
has
been
ingeniously
formulated.
This
new
can
be
produced
high
efficiency
through
the
simple
combination
of
commercially
available
methyl
3‐thiopropanoate
and
CD
3
I.
novel
SCD
exhibits
excellent
reactivity
electrophiles
such
alkyl
iodides,
benzyl
chlorides,
aryl
halides
(I,
Br)
triflates,
resulting
in
levels
deuterium
content
(99%
D).
Representative
methylthiolated
biomolecules,
Sulfoxaflor,
have
synthesized
for
use
pharmaceutical
discovery
development.
