The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8363 - 8375
Published: June 7, 2024
Palladium-catalyzed
decarboxylation
of
5-methylene-1,3-oxazinan-2-ones
and
5-methylene-1,3-dioxan-2-ones
to
generate
aza-π-allylpalladium
oxa-π-allylpalladium
1,4-dipoles
for
[4
+
2]
cycloaddition
reaction
with
1,3,5-triazinanes
was
developed,
affording
a
wide
range
hexahydropyrimidine
1,3-oxazinane
derivatives
in
good
excellent
yields
(up
99%).
The
acyclic
sulfonamido-substituted
allylic
carbonates
as
1,4-dipole
precursors
also
apply
the
developed
synthesized
strategy,
achieving
synthesis
hexahydropyrimidines.
Moreover,
situ-generated
undergoing
dimeric
4]
were
demonstrated
by
construction
1,5-diazocane
derivatives.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(21)
Published: Feb. 7, 2024
Linearly
fused
polycyclic
piperidines
represent
common
substructures
in
natural
products
and
biologically
active
small
molecules.
We
have
devised
a
Pd-catalyzed
annulation
strategy
to
these
compounds
that
converts
readily
available
2-tetralones
indanones
into
scaffolds
with
the
potential
for
control
of
both
enantio-
diastereoselectivity.
Importantly,
can
be
chemoselectively
functionalized,
providing
an
efficient
robust
methodology
important
nitrogen-containing
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8951 - 8959
Published: May 30, 2024
Palladium-catalyzed
(4
+
1)
annulation
of
4-vinylbenzodioxinones
with
sulfur
ylides
has
been
developed
to
afford
various
dihydrobenzofuran
derivatives
in
moderate
high
yields
excellent
diastereoselectivities.
The
scale-up
reaction
and
further
derivations
the
product
worked
well,
demonstrating
application
potential
current
organic
synthesis.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4131 - 4137
Published: Jan. 1, 2024
A
palladium-catalyzed
decarboxylative
(5
+
5)
cyclization
reaction
of
vinyloxazolidine-2,4-diones
for
the
synthesis
ten-membered
N,O-containing
heterocycles
is
disclosed.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(45)
Published: Oct. 19, 2023
We
herein
report
a
two-step
approach
for
the
enantioselective
synthesis
of
novel
chiral
δ-lactams.
By
using
cooperative
ITU/achiral
Pd-catalyst
system,
this
protocol
proceeds
via
an
asymmetric
α-allylation
activated
aryl
esters
first,
followed
by
acid-mediated
lactam
formation.
A
variety
differently
substituted
products
could
be
obtained
with
usually
high
levels
enantioselectivities
and
in
reasonable
yields
(16
examples,
up
to
98
:
2
er
73
%
yield
over
two
steps).
In
addition,
further
utilizations
transformations
exocyclic
double
bond
were
successfully
carried
out
as
well.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8363 - 8375
Published: June 7, 2024
Palladium-catalyzed
decarboxylation
of
5-methylene-1,3-oxazinan-2-ones
and
5-methylene-1,3-dioxan-2-ones
to
generate
aza-π-allylpalladium
oxa-π-allylpalladium
1,4-dipoles
for
[4
+
2]
cycloaddition
reaction
with
1,3,5-triazinanes
was
developed,
affording
a
wide
range
hexahydropyrimidine
1,3-oxazinane
derivatives
in
good
excellent
yields
(up
99%).
The
acyclic
sulfonamido-substituted
allylic
carbonates
as
1,4-dipole
precursors
also
apply
the
developed
synthesized
strategy,
achieving
synthesis
hexahydropyrimidines.
Moreover,
situ-generated
undergoing
dimeric
4]
were
demonstrated
by
construction
1,5-diazocane
derivatives.
