Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(32), P. 5978 - 5983
Published: Aug. 7, 2023
An
electrochemical
oxidation-induced
cyclization
of
ortho-alkyl-substituted
azobenzenes
has
been
developed.
The
direct
benzylic
C-H
functionalization
with
respect
to
could
proceed
in
the
absence
any
catalyst
or
external
chemical
oxidant
afford
a
number
2H-indazole
derivatives
moderate
good
yields.
This
protocol
enables
reuse
byproduct
same
2H-indazoles,
thus
significantly
reducing
pollution
discharge
synthetic
chemistry.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(15), P. 3101 - 3104
Published: Jan. 1, 2023
Herein,
a
Cu(II)-catalyzed
facile
construction
of
synthetically
valuable
spiro
compounds
from
β-naphthols
in
air
is
reported,
which
N,N-dimethylaminoethanol
(DMEA)
serves
as
an
efficient
and
unique
C1
synthon.
This
transformation
proceeds
through
ortho-quinone
methide
(o-QM)
formation/Michael
addition/dearomatization
sequence,
affording
various
spiro(naphthalenenaphtho)furan-2-ones
moderate
to
excellent
yields.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(6), P. 1325 - 1330
Published: Feb. 2, 2024
Abstract
Copper‐catalyzed
silylarylation
of
N
‐(arylsulfonyl)acrylamides
via
a
tandem
silyl
radical
addition/1,4‐aryl
migration/desulfonylation
sequence
has
been
developed.
This
method
employs
silanes
as
the
precursor
and
di‐
tert
‐butyl
peroxide
(DTBP)
initiator.
By
using
this
cascade
procedure,
series
β
‐silyl
amide‐pharmaceutical
hybrids
which
contain
an
α
‐all‐carbon
quaternary
stereocenter
were
facilely
synthesized.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(8), P. 1205 - 1210
Published: March 22, 2023
Abstract
A
practical
electrochemical
Minisci‐type
reaction
for
the
synthesis
of
silylated
heterocycles
is
described.
Using
N
‐hydroxyphthalimide
(NHPI)
as
hydrogen
atom
transfer
(HAT)
catalyst
and
trialkylsilanes
silyl
radical
sources,
a
wide
range
electron‐deficient
in‐cluding
quinoline,
quinoxaline,
phthalazine,
3,6‐dichloropyridazine,
phenanthridine,
6‐chloroimidazo[1,2‐
b
]pyridazine
coumarin,
etc.
were
easily
converted
to
corresponding
products
in
37–83%
yields.
magnified
image
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(32), P. 5978 - 5983
Published: Aug. 7, 2023
An
electrochemical
oxidation-induced
cyclization
of
ortho-alkyl-substituted
azobenzenes
has
been
developed.
The
direct
benzylic
C-H
functionalization
with
respect
to
could
proceed
in
the
absence
any
catalyst
or
external
chemical
oxidant
afford
a
number
2H-indazole
derivatives
moderate
good
yields.
This
protocol
enables
reuse
byproduct
same
2H-indazoles,
thus
significantly
reducing
pollution
discharge
synthetic
chemistry.
