Synergistic Photoredox and Electrochemical Catalysis in Organic Synthesis and Late‐Stage Functionalizations DOI

Ci‐Yang Sun,

Ting‐Jun Lin,

Yu‐Yu Chen

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(14)

Published: Feb. 7, 2024

Abstract This review delves into the innovative field of interfacial photoelectrochemical (iPEC) and (PEC) catalysis, dynamic synthesis methodologies that seamlessly integrates electrochemical photoredox catalysis for efficient environmentally friendly reactions. Utilizing minute quantities photocatalysts, visible light becomes a powerful tool, generating transient excited states to catalyze spectrum reactions through single‐electron oxidation or reduction events. The categorizes recent advancements, highlighting applications in organic synthesis, late‐stage modifications, distinctive features methodology. Despite being its early stages, this synergistic approach holds great promise propelling forward, with potential large‐scale diverse functionalizations, including asymmetric bioconjugation strategies biomolecule modifications.

Language: Английский

Copper‐Catalyzed Radical Silylarylation of Activated Alkenes: Preparation of β‐Silyl Amide‐Pharmaceutical Hybrids DOI
Fei Chen, Shiyu Liu, Li Xiao

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(6), P. 1325 - 1330

Published: Feb. 2, 2024

Abstract Copper‐catalyzed silylarylation of N ‐(arylsulfonyl)acrylamides via a tandem silyl radical addition/1,4‐aryl migration/desulfonylation sequence has been developed. This method employs silanes as the precursor and di‐ tert ‐butyl peroxide (DTBP) initiator. By using this cascade procedure, series β ‐silyl amide‐pharmaceutical hybrids which contain an α ‐all‐carbon quaternary stereocenter were facilely synthesized.

Language: Английский

Citations

9

Self‐ or Acridinium‐Catalyzed Electrophotosynthesis of Thiocyanato Heterocycles from Activated Alkenes DOI

Kaixing Gong,

Yingchun Ma,

Ping Yu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(10), P. 2352 - 2362

Published: April 5, 2024

Abstract While the emergence of electrophotochemistry provides opportunities, such a chemistry at this stage suffers from limited reaction types and high photocatalyst loadings. A self‐catalyzed electrophotosynthesis as well one with low loading is presented. These external‐oxidant‐free cyclizations are enabling applicable to range activated alkenes, affording diverse array thiocyanato heterocycles including 4‐pyrrolin‐2‐ones, isoquinoline‐1,3‐diones, indolo[2,1‐ ]isoquinolin‐6(5 H )‐ones, benzoimidazo[2,1‐ )‐ones indolin‐2‐ones, protocols amenable late‐stage diversification complex molecular architectures gram‐scale syntheses. Sunlight could serve light source, be conducted in an all‐solar‐driven mode using commercially available photovoltaic panel produce electricity.

Language: Английский

Citations

9

Recent Advances on C—H Functionalization via Oxidative Electrophotocatalysis DOI

Aman Hasil,

Rui Chang,

Juntao Ye

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(3), P. 728 - 728

Published: Jan. 1, 2024

Language: Английский

Citations

8

Electrochemical Silylation of Electron‐Deficient Heterocycles Using N‐Hydroxyphthalimide as HAT Catalyst DOI
Cong Jiang, Yujie Liao, Heng Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(8), P. 1205 - 1210

Published: March 22, 2023

Abstract A practical electrochemical Minisci‐type reaction for the synthesis of silylated heterocycles is described. Using N ‐hydroxyphthalimide (NHPI) as hydrogen atom transfer (HAT) catalyst and trialkylsilanes silyl radical sources, a wide range electron‐deficient in‐cluding quinoline, quinoxaline, phthalazine, 3,6‐dichloropyridazine, phenanthridine, 6‐chloroimidazo[1,2‐ b ]pyridazine coumarin, etc. were easily converted to corresponding products in 37–83% yields. magnified image

Language: Английский

Citations

14

Synergistic Photoredox and Electrochemical Catalysis in Organic Synthesis and Late‐Stage Functionalizations DOI

Ci‐Yang Sun,

Ting‐Jun Lin,

Yu‐Yu Chen

et al.

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(14)

Published: Feb. 7, 2024

Abstract This review delves into the innovative field of interfacial photoelectrochemical (iPEC) and (PEC) catalysis, dynamic synthesis methodologies that seamlessly integrates electrochemical photoredox catalysis for efficient environmentally friendly reactions. Utilizing minute quantities photocatalysts, visible light becomes a powerful tool, generating transient excited states to catalyze spectrum reactions through single‐electron oxidation or reduction events. The categorizes recent advancements, highlighting applications in organic synthesis, late‐stage modifications, distinctive features methodology. Despite being its early stages, this synergistic approach holds great promise propelling forward, with potential large‐scale diverse functionalizations, including asymmetric bioconjugation strategies biomolecule modifications.

Language: Английский

Citations

6